WO2017126995A1 - Composition for treatment and preventative of the human papilloma virus hpv inffction, ulcerations and boils - Google Patents

Composition for treatment and preventative of the human papilloma virus hpv inffction, ulcerations and boils Download PDF

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Publication number
WO2017126995A1
WO2017126995A1 PCT/SA2016/000001 SA2016000001W WO2017126995A1 WO 2017126995 A1 WO2017126995 A1 WO 2017126995A1 SA 2016000001 W SA2016000001 W SA 2016000001W WO 2017126995 A1 WO2017126995 A1 WO 2017126995A1
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Prior art keywords
virus
composition based
herbal composition
protection factor
myrrh
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PCT/SA2016/000001
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French (fr)
Inventor
Nadiah Abdulkarim A. Alessa
Original Assignee
Alessa Nadiah Abdulkarim A
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Application filed by Alessa Nadiah Abdulkarim A filed Critical Alessa Nadiah Abdulkarim A
Priority to CA2967506A priority Critical patent/CA2967506A1/en
Priority to PCT/SA2016/000001 priority patent/WO2017126995A1/en
Publication of WO2017126995A1 publication Critical patent/WO2017126995A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/08Mineral waters; Sea water
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/886Aloeaceae (Aloe family), e.g. aloe vera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/02Suppositories; Bougies; Bases therefor; Ovules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents

Definitions

  • HPV Human Papilloma Virus
  • HPV human papilloma virus
  • myrrh gum is used for bedsore. It is also known that resin and oil is used in treatment of Schistosomiasis according to an American Patent No. 6077513, and myrrh is also used as food or food supplements according to an American Patent Application No. 5248503. It is also used for treatment of vagina atrophy according to an international Patent Application No. 2012/123539 dated 20/152012. It is worth mentioning that myrrh is considered a kind of natural resins and it is safe for human usage.
  • Aloe Vera leaves which serve as an microbial agents according to an American Patent No. 7169414 dated 2007. It discovered a gelatinous fluid which include an antagonist to germs. Aloe Vera can also be used with other combinations to serve as an antivirus, and treatment of Aids, according to an international Patent Application No. 2012/012513 dated 26/01/2012.
  • garlic cream is used as topical treatment for skin infections, according to an international Patent Application No. 2002089826 dated 14/11/2002.
  • Garlic extract can also be used as an antibiotic according to an international Patent Application No. 2011012855 dated 30/06/2011.
  • Citrullus colocynthis plant as an anti-factor for infections. This is published in the International Journal of Current Research Vol. 2, pp. 067 - 069, 2010 - Rajamanickam, et al "Evaluation of anti - Inflammatory Activity of Citrullus colocynthis"
  • This invention compared to previous inventions has good advantages: no need for using ancient methods such as electric cauterization, laser or removal by surgery. This new method is safe and easy to use.
  • This herbal composition is used as lotion for a short period of time. It works to eliminate the existing virus and can also be used as protective procedure. Detailed Description
  • this composition is a herbal mixture of five main and effective materials with water addition:
  • Citrullus colocynthis plant is also used with a mixture of medical herbs as a safe composition to treat diabetes according to the American Patent No. 8993008 dated
  • Aloe Vera 50 grams are to be grind .Myrrh, Aloe Vera and hard sea salt are to be mixed together, and to be dissolved in 750 grams of water. Then it is put in a tight container, and placed on fire for 20 minutes and left until it cools. The Citrullus colocynthis and garlic are added. All these are to be well mixed together. It should remain in the container for 72 hours, until it is ferment. Finally it is refined and kept in a container ready for use.
  • the best way is to be used as a daily lotion after each visit to the bathroom.
  • the infected area is to be washed with mild soap first and then with the solution. This will help fast cure from the virus.
  • Example 1 Lotion for the infected area:
  • Example 3 - suppositories for vagina:

Abstract

This patent is related to the treatment of the human papilloma which belongs to a variant group of virus, considered as (DAN). It is infectious to skin and mucous membranes. It is transmittable from person to person through sexual touch, or touching infected areas. This virus may cause different kinds of cancer for both men and women, since approximately 90% of anal cancer cases in men and women, about 70% of mouth and pharynx cancer, 65% - 70% of cervix cancer and 50% of penis cancer for men is caused by this virus. In addition this virus causes other diseases for both men and women such as thalols on genitals and different skin thalols. There is no effective remedy for this virus, so one has to be watchful and take the required prevention measures. Based on this data I have made a composition which helps curing and eliminating this virus as soon as it appears on the skin. Thus the patient does not have to use the traditional treatments such as electric cauterization and other methods. The most important ingredients of this remedy is a herbal combination, consists of an Aloe Vera, Citrullus colocynthis, hard sea salt, myrrh and garlic.)

Description

COMPOSITION FOR TREATMENT AND PREVENTATIVE OF THE HUMAN PAPILLOMA VIRUS HPV INFECTION , ULCERATIONS AND BOILS
Description
Field of the invention
A composition For Treatment And Prevention Of The Human Papilloma Virus (HPV) Infection, Ulcerations And Boils.
Background of the Invention:
The human papilloma virus (HPV) is one of the most diseases transmitted on sexual basis. This could happen through simply touching genitals or touching infected areas. It is estimated that 50% - 80% of (HPV) infection cases were through active genitals. And most of these cases , on a percentage comes up to 50% are usually infected by (HPV) virus which causes various kind s of cancer , the most important of which are cervix , anal ,penis, mouth, and gorge cancer , which infect different parts of the mouth , including lips , tongue base ,upper gorge ,tonsils and throat.
At the beginning of the recent century studies revealed great irrationalized increase of the prevalence rate regarding these diseases, and their occurrence among ages that were not subject to these diseases in this high rate. Although these studies took place in different countries such as Britain, America, Sweden, they met the same results, and revealed similar patterns of rates and risk factors.
The main methods used nowadays in the treatment of such diseases is either surgical removal , cooling technology, laser treatment , using medicines with povidone or other methods adopted in modern medicine. These methods do not solve the root of the disease. For instance cooling method only removes the virus from the surface of the skin and does not treat the virus itself, so there is high possibility that the virus appears again and in greater numbers. Thus the diseased person remains in a vicious circle. That is why we used a new technology of alternative medicine in this invention through a herbal composition that will solve the root of the problem if Allah bless.
Treatment with natural herbs has its characteristics and is honorable by some community members. They use chamomile herbs for many diseases and troubles, such as upset stomach and colds, also myrrh is used as incense or taken orally to drive out gases, and according to American Patent No. 5350774 dated 27/09/1994 myrrh is used as useful topical treatment for skin troubles such as natural burns and the like, and it can be mixed with other herbs.
I also learned from the American Patent No. 471919 the myrrh gum is used for bedsore. It is also known that resin and oil is used in treatment of Schistosomiasis according to an American Patent No. 6077513, and myrrh is also used as food or food supplements according to an American Patent Application No. 5248503. It is also used for treatment of vagina atrophy according to an international Patent Application No. 2012/123539 dated 20/09/2012. It is worth mentioning that myrrh is considered a kind of natural resins and it is safe for human usage.
Rashad A. Abdul Guni et al: (Myrrh and trematodoses in Egypt. An overview of safety, efficacy and effectiveness profiles, published in ELSEVIER magazine, volume 58, issue 3 September 2009, Parasitological site. And there are further studies that confirm the safety of myrrh.
Another herb is Aloe Vera leaves which serve as an microbial agents according to an American Patent No. 7169414 dated 2007. It discovered a gelatinous fluid which include an antagonist to germs. Aloe Vera can also be used with other combinations to serve as an antivirus, and treatment of Aids, according to an international Patent Application No. 2012/012513 dated 26/01/2012.
There is an international Patent Application No. 2013/171607 dated 21/11/2013. It discovered a good composition for topical use to treat human papilloma virus (HPV). It is extracted from curcuma, Aloe Vera and Amla. It is worth mentioning that both Aloe Vera extract and Aloe Vera quite safe materials. And used in treatment of active ulcerative colitis. (Alimentary Pharmacology and Therapeutic, Volume 19. Issue 7, pages 739 - 747, April 2004. However many studies proved the safety of Aloe Vera extract.
It is also discovered that garlic cream is used as topical treatment for skin infections, according to an international Patent Application No. 2002089826 dated 14/11/2002. Garlic extract can also be used as an antibiotic according to an international Patent Application No. 2011012855 dated 30/06/2011.
It is also discovered that Citrullus colocynthis plant as an anti-factor for infections. This is published in the International Journal of Current Research Vol. 2, pp. 067 - 069, 2010 - Rajamanickam, et al "Evaluation of anti - Inflammatory Activity of Citrullus colocynthis"
A lady suffered from (HPV) for a long time. She used recently available methods with little or no use, because symptoms soon appear again which has bad impact on the diseased person. And since I have the experience in herbs science I did my best to make a herbal composition helps in treatment and elimination or mitigation of the disease. By Allah will, the composition is made and tested on the lady. The results were excellent .Later, the composition was applied to other two similar cases and it also realized excellent results.
General description of the Invention
This invention compared to previous inventions has good advantages: no need for using ancient methods such as electric cauterization, laser or removal by surgery. This new method is safe and easy to use. This herbal composition is used as lotion for a short period of time. It works to eliminate the existing virus and can also be used as protective procedure. Detailed Description
As for detailed description, this composition is a herbal mixture of five main and effective materials with water addition:
(It consists of an Aloe Vera, Citrullus colocynthis, hard sea salt, myrrh and garlic.) Ancient Chinese Medicine proved that myrrh is not toxic, and does not have side effects. The Chinese Patent No. 101632756 dated 24/08/2011 proved the benefits of myrrh in safely curing tumors.
Studies has proved that Aloe Vera can be used safely as food to prevent some diseases.
This was further proved by patent Application No. 2602066.
Citrullus colocynthis plant is also used with a mixture of medical herbs as a safe composition to treat diabetes according to the American Patent No. 8993008 dated
31/03/2015.
As for the recent patent to treat (HPV) is a composition consists of Aloe Vera, Citrullus
Colocynthis , hard sea salt, myrrh and garlic.
These ingredients are to be mixed in a specific portion as follows:
40 grams of myrrh
50 grams of hard sea salt
25 grams of Citrullus colocynthis.
35 grams of garlic
50 grams of Aloe Vera These materials are to be grind .Myrrh, Aloe Vera and hard sea salt are to be mixed together, and to be dissolved in 750 grams of water. Then it is put in a tight container, and placed on fire for 20 minutes and left until it cools. The Citrullus colocynthis and garlic are added. All these are to be well mixed together. It should remain in the container for 72 hours, until it is ferment. Finally it is refined and kept in a container ready for use.
Usage :
The best way is to be used as a daily lotion after each visit to the bathroom. The infected area is to be washed with mild soap first and then with the solution. This will help fast cure from the virus.
Example 1 - Lotion for the infected area:
40 grams of myrrh
50 gram of hard sea salt
25 grams of Citrullus colocynthis
35 grams of garlic
50 grams of Aloe Vera
750 ml. of water
Example 2 - Lotion for the vagina:
40 grams of myrrh
50 grams of hard sea salt 25 grams of Citrullus colocynthis
35 grams of garlic
50 grams of Aloe Vera
01 gram of sodium benzoate
10 grams of paraffin oil 03 grams of Carpopol
One liter of water
Example 3 - suppositories for vagina:
40 grams of myrrh
50 grams of hard sea salt
25 grams of Citrullus colocynthis
35 grams of garlic
50 grams of Aloe Vera
13 grams of venylpyrolidine
52 grams silica hydrate
52 grams of propylene glycol
52 grams of glycerin oleate
750 grams of polyethylene glycol 1000
450 grams of polyethylene glycol 4000
200 grams of polyethylene glycol 400 Example 4: A Cream for Vagina and infected
40 grams of myrrh
50 grams of hard sea salt
25 grams of Citrullus colocynthis
35 grams garlic
50 grams of Aloe Vera
30 grams of cetyl alcohol
85 grams of stearyl alcohol
10 grams of isopropylmyristst
200 grams of propylene glycol
20 grams of polysorbate 60
1.2 grams of potassium hydroxide
200 grams of hydroxyl propyl cellulose

Claims

Claims
1 - Herbal Composition and processes of formulation for Herbal Medicine Consisting of Aloe Vera, Citrullus colocynthis, hard sea salt, myrrh and garlic.
2 - A herbal composition based on protection factor 1, including Aloe Vera forming 5 - 65 from the composition.
3 - Herbal composition based on protection factor 1, consisting of Citrullus colocynthis with a percentage from 1 to 29% of the composition.
4 - Herbal composition based on protection factor 1, consisting of hard sea salt with percentage of 3 - 75% from the whole composition.
5 - Herbal composition based on protection factor 1, consists of myrrh with a percentage from 3 - 55% of the composition.
6 - Herbal composition based on protection factor 1, consist of garlic with percentage of 5 - 39% of the composition.
7 - Methods of making herbal composition based on factor 1 :
A - These ingredients should be grind until it is soft powder. Then Aloe Vera, hard sea salt and myrrh are to be mixed together.
B - The mixture of materials in (A) is to be mixed in 750 ml. of boiling water for 20 minutes in a well tight container, and to be left until it cools.
C - The powder of garlic and Citrullus colocynthis is mixed with the combination in (B) when water becomes cool. The mixture is left for 72 hours until it ferments.
D -Then the mixture is to be refined after homogeneity of the ingredients. The solution is then put in containers ready for external use as lotion for infected areas.
8 - A herbal composition based on protection factor 1 is distinguished with homogeneity in a form of pharmacy medicine to treat (HPV). 9 - A method of making herbal composition based on protection factor 1. The final product is a gelatinous solution or cream. It contains non effective additives.
10 - A method of making herbal composition based on protection factor 1. The final product is in a form of vaginal and anal suppositories, and vaginal lotion. It includes non effective additives.
PCT/SA2016/000001 2016-01-18 2016-01-18 Composition for treatment and preventative of the human papilloma virus hpv inffction, ulcerations and boils WO2017126995A1 (en)

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CA2967506A CA2967506A1 (en) 2016-01-18 2016-01-18 Composition for treatment and preventative of the human papilloma virus hpv infection, ulcerations and boils
PCT/SA2016/000001 WO2017126995A1 (en) 2016-01-18 2016-01-18 Composition for treatment and preventative of the human papilloma virus hpv inffction, ulcerations and boils

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Cited By (1)

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CN115066250A (en) * 2019-12-15 2022-09-16 巴诺伊阿玛甘泰伯有限公司 Herbal compounds and methods for treating infections, vulvovaginal and pelvic organ inflammation

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* Cited by examiner, † Cited by third party
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CN115066250A (en) * 2019-12-15 2022-09-16 巴诺伊阿玛甘泰伯有限公司 Herbal compounds and methods for treating infections, vulvovaginal and pelvic organ inflammation

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