Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which is unstable in low pH. The link may comprise a...http://www.google.fr/patents/US4997913?utm_source=gb-gplus-shareBrevet US4997913 - pH-sensitive immunoconjugates and methods for their use in tumor therapy
pH-sensitive immunoconjugates and methods for their use in tumor therapy
