Antibodies are disclosed which specifically bind to native PrP.sup.Sc in situ. Preferred antibodies bind only to the native PrP.sup.Sc of a particular species e.g., human, cow, sheep, pig, etc. Particularly preferred antibodies bind specifically to a particular isoform of human PrP.sup.Sc....http://www.google.fr/patents/US5846533?utm_source=gb-gplus-shareBrevet US5846533 - Antibodies specific for native PrP.sup.Sc
