In a preferred embodiment, taxol is treated with mesyl chloride to prepare a taxol derivative with a contracted A-ring, which has comparable activity to taxol in a tubulin depolymerization assay, and which shows cytotoxicity against KB cells in a cell culture assay. In an alternate preferred embodiment,...http://www.google.fr/patents/US5296506?utm_source=gb-gplus-shareBrevet US5296506 - Rearranged taxol compounds and method of using in testing of in vivo activity
Rearranged taxol compounds and method of using in testing of in vivo activity
