The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are suppressed by antisense polynucleotides and/or by...http://www.google.fr/patents/US5545806?utm_source=gb-gplus-shareBrevet US5545806 - Ransgenic non-human animals for producing heterologous antibodies
Ransgenic non-human animals for producing heterologous antibodies
