The invention provides a method of nucleic acid sequence analysis based on the ligation of one or more sets of encoded adaptors to the terminus of a target polynucleotide. Encoded adaptors whose protruding strands form perfectly matched duplexes with the complementary protruding strands of the target...http://www.google.fr/patents/US6013445?utm_source=gb-gplus-shareBrevet US6013445 - Massively parallel signature sequencing by ligation of encoded adaptors
Massively parallel signature sequencing by ligation of encoded adaptors