This invention relates to the methods, apparatus, reagents and mixtures of reagents for sequencing natural or recombinant DNA and other polynucleotides. In particular, this invention relates to a method for sequencing polynucleotides based on mass spectrometry to determine which of the four bases (adenine,...http://www.google.fr/patents/US5003059?utm_source=gb-gplus-shareBrevet US5003059 - Determining DNA sequences by mass spectrometry