The present invention is directed to novel methods for identifying small molecule ligands that are capable of binding with high affinity to a biological target molecule of interest. High affinity binding ligands identified by the described methods find use, for example, as small molecule lead compounds...http://www.google.fr/patents/US6344330?utm_source=gb-gplus-shareBrevet US6344330 - Pharmacophore recombination for the identification of small molecule drug lead compounds
Pharmacophore recombination for the identification of small molecule drug ...