Polynucleotide encoding modified HIV Env polypeptides are disclosed. The Env polypeptides are modified in the region of amino acids 420-436 so as to expose at least part of the CD4 binding region. Methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also prov...http://www.google.fr/patents/US6689879?utm_source=gb-gplus-shareBrevet US6689879 - Modified HIV Env polypeptides
