The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance with the invention, cells derived from a desired tissue are inoculated and grown on a pre-established stromal...http://www.google.fr/patents/US4963489?utm_source=gb-gplus-shareBrevet US4963489 - Three-dimensional cell and tissue culture system