This invention provides methods of obtaining novel polynucleotides and encoded polypeptides by the use of non-stochastic methods of directed evolution (DirectEvolution). A particular advantage of exonuclease-mediated reassembly methods is the ability to reassemble nucleic acid strands that would otherwise...http://www.google.fr/patents/US6361974?utm_source=gb-gplus-shareBrevet US6361974 - Exonuclease-mediated nucleic acid reassembly in directed evolution
Exonuclease-mediated nucleic acid reassembly in directed evolution
