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US006925393B1
(12) United States Patent ao) Patent No.: us 6,925,393 Bi
Kalatz et al. (45) Date of Patent: Aug. 2,2005
(54) SYSTEM FOR THE EXTRAPOLATION OF GLUCOSE CONCENTRATION
(75) Inventors: Brit Kalatz, Ulm (DE); Udo Hoss, Sherman Oaks, CA (US)
(73) Assignee: Roche Diagnostics GmbH, Mannheim (DE)
( * ) Notice: Subject to any disclaimer, the term ol this patent is extended or adjusted under 35 U.S.C. 154(b) by 116 days.
(21) Appl. No.: 09/711,855
(22) Filed: Nov. 13, 2000
(30) Foreign Application Priority Data
Nov. 18, 1999 (DE) 199 55 734
(51) Int. CI.7 G06F 19/00; G01N 33/48;
G01N 31/00
(52) U.S. CI 702/27; 702/19; 702/22
(58) Field of Search 702/27, 19, 22;
422/68.1; 703/11, 12
(56) References Cited
U.S. PATENT DOCUMENTS
4,731,726 A 3/1988 Allen, III 364/416
5,019,974 A 5/1991 Beckers 364/413.02
5,216,597 A 6/1993 Beckers 364/413.02
5,507,288 A 4/1996 Bocker et al 128/633
5,542,420 A * 8/1996 Goldman et al 600/301
5,822,715 A 10/1998 Worthington et al 702/19
5,840,020 A 11/1998 Heinonen et al 600/309
5,997,475 A 12/1999 Bortz 600/300
6,180,416 Bl 1/2001 Kurnik et al 436/518
FOREIGN PATENT DOCUMENTS
DE 44 15 896 11/1995
DE 197 25 676 Al 12/1998
EP 0 834 825 4/1998
WO WO 97/28737 8/1997
McGilvery et al. Biochemistry: A Functional Approach. W.B. Saunders Company, 1983, third edition, pp. 520-522 and 738-742.*
Walsh, J. et al. "STOP the Rollercoaster How to Take Charge ol Your Blood Sugars in Diabetes", Torrey Pines Press, 1996 (pp. 123-125).
E.D. Lehmann et al. "An Integrated Approach for the Computer-Assisted Treatment ol Diabetic Patients on Insulin", Med. Inform. (1992), vol. 17, No. 2, 105-123. G. Freckmann et al. "Recent advances in continuous glucose monitoring", Exp Clin Endocrinol Diabetes 190 (2001) Suppl 2: S347-S357.
* cited by examiner
Primary Examiner—Ardin H. Marschel
Assistant Examiner—Cheyne Ly
(74) Attorney, Agent, or Firm—-Jill L. Woodburn; Richard T. Knauer; Sujatha Subramaniam
A system for the extrapolation ol a glucose concentration has a data input device for entering administered insulin doses and their times ol administration, a data input device for entering the carbohydrates consumed or to be consumed, a unit for determining an actual glucose concentration at a point in time (ta) in a patient's bodily fluid, a memory unit, and an evaluation unit for evaluation ol the data stored in the memory unit, and for the extrapolation ol a glucose concentration at a point in time tp, whereby tp is alter ta The extrapolation includes determining the portion (1^,,^) ol insulin doses that become effective between ta and tp; determining the portion ol consumed carbohydrate units KH^yj., that become effective between ta and tp; and determining an extrapolated glucose concentration G at the point
