United States Patent [i9] [ii] Patent Number: 5,053,033
Clarke  Date of Patent: Oct. 1, 1991
FOREIGN PATENT DOCUMENTS
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Green et al., Cytotoxicity and Mutagenicity of Low
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Liu et al., Restenosis After Coronary Angioplasty, vol.
79, Circulation, pp. 1374-1387 (1989).
Primary Examiner—Stephen C. Pellegrino
Assistant Examiner—Steven J. Shumaker
Attorney, Agent, or Firm—Thomas J. Engellenner
Restenosis following angioplasty can be inhibited by reducing the proliferation of smooth muscle cells in the blood vessel walls at an angioplasty site, and such reduction in cell proliferation can be accomplished by irradiating the angioplasty site with radiation in the ultraviolet (UV) wavelength range. The ultraviolet radiation is preferably delivered via an optical fiber or other waveguide incorporated, for example, into a percutaneous catheter. In operation, the ultraviolet radiation kills smooth muscle cells at the site, thereby reducing the risk of restenosis, while minimizing damage to surrounding tissue.
6 Claims, 4 Drawing Sheets