(12) United States Patent ao) Patent No.: us 6,500,108 Bi
Sorensen et al. (45) Date of Patent: Dec. 31,2002
(54) RADIATION DELIVERY SYSTEM AND METHOD
(75) Inventors: Scott A. Sorensen, Overland Park, KS (US); Thomas W. Robison, Los Alamos, NM (US); Craig M. V. Taylor, Jemez Springs, NM (US)
(73) Assignee: The Regents of the University of California, Los Alamos, NM (US)
( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days.
(21) Appl. No.: 09/693,527
(22) Filed: Oct. 20, 2000
Related U.S. Application Data
(60) Provisional application No. 60/161,095, filed on Oct. 22, 1999.
(51) Int. C I. A61N 5/00
(52) U.S. CI 600/3; 424/1.11; 424/1.53
(58) Field of Search 600/1-8; 424/1.11,
424/1.53; 534/10
(56) References Cited
U.S. PATENT DOCUMENTS
5,683,345 A 11/1997 Waksman et al 600/3
5,707,332 A 1/1998 Weinberger 600/3
5,730,698 A 3/1998 Fischell et al 600/3
5,871,436 A 2/1999 Eury 600/3
5,891,956 A 4/1999 Smith et al 525/56
5,899,882 A 5/1999 Waksman et al 604/96
5,942,209 A 8/1999 Leavitt et al 424/1.25
6,077,213 A 6/2000 Ciezki et al 600/3
6,103,295 A 8/2000 Chan et al 427/5
6,106,454 A 8/2000 Berg et al 600/3
6,117,065 A 9/2000 Hastings et al 600/3
FOREIGN PATENT DOCUMENTS
WO WO9901179 1/1999 600/3
OTHER PUBLICATIONS
Colin D. Bain and George M. Whitesides, "Molecular-Level Control Over Surface Order in Self-Assembled Monolayer Films of Thiols on Gold," Science, vol. 240, pp. 62-63, Apr. 1988.
Murali Sastry, Vijaya Patil, and K.S. Mayya, "Selective Binding of Divalent Cations at the Surface of Self-Assembled Monolayers of an Aromatic Bifunctional Molecule Studied on a Quartz Crystal Microbalance," J. Phys. Chem. B. 1997, 101, 1167-1170.
Simon Flink, Frank C. J. M. van Veggel, and David N. Reinhoudt, "Recognition of Cations by Self-Assembled Monolayers of Crown Ethers," J. Phys. Chem. B. 1999,103, 6515-6520.
Roger Alberto, Roger Schibli, and August P. Schubiger, "First Application of fac-[99mTc(OH2)3(CO)3]+ Fl in Bioorganometallic Chemistry: Design, Structure, and in Vitro Affinity of a SOHT^ Receptor Ligand Labeled with "TMTc," J. Am. Chem Soc. 1999, 121, 6076-6077.
Roger Alberto, Roger Schibli, Andre Egli, and August P. Schubiger, "A Novel Organometallic Aqua Complex of Technetium for the Labeling of Biomolecules: Synthesis of [99mTc(OH2)3(CO)3] from [99mTc04]- in Aqueous Solution and Its Reaction with a Bifunctional Ligand," J. Am Chem. Soc. 1998, 120, 7987-7988.
Ralph G. Nuzzo and David L. Allara, "Adsorption of Bifuntional Organic Disulfides on Gold Surfaces," J. Am. Chem. Soc. 1983, 105, 4481-4483.
Urs O. Hafeli, Matthew C. Warburton, and Uziel Landau, "Eletrodeposition of Radioactive Rhenium onto Stents to Prevent Restenosis," Biomaterials 19, 1998, 925-933.
Primary Examiner—Max Hindenburg
(74) Attorney, Agent, or Firm—Samuel L. Borkowsky
