(i9) United States
(12) Patent Application Publication oo) Pub. No.: US 2010/0240975 Al
Goode, JR. et al. (43) Pub. Date: Sep. 23,2010
(75) Inventors: Paul V. Goode, JR., Cherry Hill, NJ (US); James H. Brauker, Addison, MI (US); Apurv U. Kamath, San Diego, CA (US); James Patrick Thrower, Oakland, NJ (US); Victoria Carr-Brendel, San Diego, CA(US)
KNOBBE, MARTENS, OLSEN & BEAR, LLP 2040 MAIN STREET, FOURTEENTH FLOOR IRVINE, CA 92614 (US)
(73) Assignee: DexCom, Inc., San Diego, CA (US)
(21) Appl.No.: 12/791,686
(22) Filed: Jun. 1, 2010
Related U.S. Application Data
(63) Continuation of application No. 10/648,849, filed on Aug. 22, 2003.
(51) Int. CI.
A61B 5/1473 (2006.01)
(52) U.S. CI 600/347; 600/365
Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.