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United States Patent [i9]

Bolton et al.

US005527713A [ii] Patent Number: [45] Date of Patent:

5,527,713 Jun. 18, 1996

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Y. Manabe et al., J. Lab. Clin. Med. 104: 445-454 (1984) "Production Of A Monoclonal Antibody-Methotrexate Conjugate Utilizing Dextran T-40

L. B. Shih et al., Int. J. Cancer 41: 832-839 (1988), "Site-Specific Linkage Of Methotrexate To (MAb) . . . Using An Intermediate Carrier".

D. A. Hafier et al., J. Immunol. 142: 2590-2596 (1989), "Mechanisms Of Immune Memory: T Cell Activation ... ". J. W. Bulte et al., Mag. Res. in Med. 25: 148-157 (1992), "Specific MR Imaging ... Antibody-Guided Dextran-Magnetite Particles".

A. R. Oseroff et al., Proc. Natl. Acad. Sci. USA 83: 8744-8748 (1986), Antibody-Targeted Photolysis ... Using Antibody-Chlorin Conjugages.

S. C. Meuer et al., J. Exp. Med. 158: 988-993 (1983),
Antigen-Like Effects ... On Human T Cell Clones.
A. Altaian, et al., Crit. Revs, in Immunol. 10: 347-391
(1990), "T Lymphocyte Activation: A Biological Model Of
Signal Transduction".

P. K. A. Mongini J. Immunol. 148: 3892-3901 (1992),
"Membrane IgM-Mediated Signaling Of Human B Cells".
H. Maeda, et al., Bioconjugate Chem. 3: 351-362 (1992),
"Conjugates Of Anticancer Agents And Polymers: Advan-
tages Of Macromolecular Therapeutics In Vivo".

Primary Examiner—James C. Housel
Assistant Examiner—Christopher L. Chi
Attorney, Agent, or Firm—Michelle A. Kaye

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