[54] MOLECULAR DETECTION APPARATUS
[75] Inventors: William L. Reber, Schaumburg, 111.;
Michael K. Stenstrom, Los Angeles,
Calif.; Cary D. Perttunen, Shelby
Township, Mich.
[73] Assignee: Motorola, Inc., Schaumburg, 111.
[21] Appl. No.: 08/838,491 [22] Filed: Apr. 7, 1997
[51] Int. CI.6 COIN 33/543; G01N 1/14;
G01N 21/00; G01N 21/29
[52] U.S. CI 436/518; 436/805; 436/810;
422/50; 422/55; 422/56; 422/58; 422/82.05;
422/310
[58] Field of Search 436/518, 805,
436/810; 422/50, 56, 58, 82.05, 310; 210/493.5;
435/278.1, 810
[56] References Cited
U.S. PATENT DOCUMENTS
2,925,171 2/1960 Eaton .
4,720,455 1/1988 Babu et al 435/7
5,001,048 3/1991 Taylor et al 435/4
5,122,452 6/1992 Yamazaki et al 435/7.92
5,268,305 12/1993 Ribi et al 436/501
5,573,921 11/1996 Behnke et al 435/7.92
5,656,503 8/1997 May et al 436/514
OTHER PUBLICATIONS
"Berkeley Lab Invents Instant E. Coli Test", New Technology Week, Dec. 16, 1996, p. 10.
"Direct Colorimetric Detection of a Receptor-Ligand Interaction by a Polymerized Bilayer assembly", Deborah H. Charych, Jon O. Nagy, Wayne Spevak, & Mark D. bednarski; Science, vol. 261, Ju. 30, 1993, pp. 585-588.
"Polydiacetylene Liposomes Functionalized with Sialic
Acid Bind and Colorimetrically Detect Influenza Virus",
Anke Reichert, Jon O. Nagy, Spevak, & Deborah Charych;
J. Am. Chem. Soc. 1995, 117, 829-830.
"A 'litmus test' for molecular recognition using artificial
membranes", Deborah Charych, Quan Cheng, Anke
Reichert, Geroffrey Kuziemko, Mark Stroh, Jon O. Nagy,
Wayne Spevak, & Raymond C. Stevens; Chemistry &
Biology, Feb. 1996; 3:113-120.
"Direct Flu Detection and Potential Therapeutics", Ernest
Orlando Lawrence Berkeley National Laboratory.
"New Sensor Provide First Instant Test for Toxic E. Coli
Organism", Jeffery Kahn, Berkeley Lab Research News,
Dec. 10, 1996, pp. 1-3.
Charych et al. Mater. Res. Soc. Symp. Proc. 292: 153-161
(B), 1993.
Kramer. J. AOAC International 79: 1245-1254, 1996.
Spevak et al. Adv. Mater. 7 (1): 85-89, 1995.
Pan et al. Langmuir 13: 1365-1367, Mar. 1997.
Taylor et al. In: Protein Immobilization Fundamentals and
Applications. (Ed)RFTaylor, Chapter 8, pp. 263-303, 1991.
Primary Examiner—James C. Housel
Assistant Examiner—S. Devi
Attorney, Agent, or Firm—Jeffrey G. Toler; James E.
Gauger
