System for washing and processing of cells for delivery thereof to tissue

(21) Appl.No.: 11/460,635

(22) Filed: Jul. 28, 2006

(65) Prior Publication Data

US 2007/0106208 Al May 10, 2007

Related U.S. Application Data

(60) Provisional application No. 60/734,035, filed on Nov. 4, 2005, provisional application No. 60/742,224, filed on Dec. 5, 2005, provisional application No. 60/771, 206, filed on Feb. 7, 2006.

(51) Int. CI.

G01N 35/10 (2006.01)

(52) U.S. CI 604/93.01; 422/100; 422/101;

422/102; 422/103; 435/308.1

(58) Field of Classification Search 422/100,

422/101, 102, 103; 604/93.01; 435/308.1;

73/863.01

See application file for complete search history.

(56) References Cited

U.S. PATENT DOCUMENTS 4,677,980 A 7/1987 Reillyetal.

(Continued)

(Continued)

OTHER PUBLICATIONS

Hydromer Coating, Hydromer, Inc. Website (www.hydromer.com/ MedicalCoatings.html), As early 1985.

(Continued)

Primary Examiner—Terry K Cecil

(7'4) Attorney, Agent, or Firm—Gregory L. Bradley; Henry E. Bartony, Jr.

A system for injecting an injectate into patient includes a first pressurizable container for holding the injectate; a patient interface in fluid connection with the first pressurizable container, the patient interface being adapted to pass the injectate into tissue of the patient; a powered injector in operative connection with the first pressurizable container to pressurize the injectate; a controller system in operative connection with powered injector; and a stereotactic localization frame adapted to be placed in operative connection with the patient interface to assist in controlling localization of the patient interface. A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.

6 Claims, 45 Drawing Sheets

U.S. PATENT DOCUMENTS

4,803,050 A * 2/1989 Mack 422/65

4,865,993 A * 9/1989 Cassaday 436/52

5,383,858 A 1/1995 Reillyetal.

5,494,035 A 2/1996 Leuthold et al.

5,526,812 A 6/1996 Dumoulin et al.

5,618,531 A 4/1997 Cherksey

5,690,815 A * 11/1997 Krasnoff et al 210/97

5,695,653 A * 12/1997 Gsell et al 210/767

5,720,720 A 2/1998 Laske et al.

5,750,103 A 5/1998 Cherksey

5,797,870 A 8/1998 March etal.

5,808,203 A 9/1998 Nolan, Jr. et al.

5,827,216 A 10/1998 Igoetal.

5,846,225 A 12/1998 Rosengart et al.

5,882,343 A 3/1999 Wilson etal.

5.997.509 A 12/1999 Rosengart et al.
6,060,048 A 5/2000 Cherksey
6,122,536 A 9/2000 Sun etal.
6,224,566 Bl 5/2001 Loeb
6,231,568 Bl 5/2001 Loeb etal.
6,319,230 Bl 11/2001 Palasisetal.
6,322,536 Bl 11/2001 Rosengart et al.
6,387,369 Bl 5/2002 Pittenger et al.

6.416.510 Bl 7/2002 Altaian etal.
6,464,662 Bl 10/2002 Raghavan et al.
6,488,661 Bl 12/2002 Spohnetal.
6,520,930 B2 2/2003 Critchlow et al.
6,549,803 Bl 4/2003 Raghavan et al.
6,572,579 Bl 6/2003 Raghavan et al.
6,585,700 Bl 7/2003 Trockietal.
6,591,129 Bl 7/2003 Ben-Haim et al.
6,595,979 Bl 7/2003 Epstein etal.
6,599,274 Bl 7/2003 Kucharczyk et al.
6,602,241 B2 8/2003 Makower et al.
6,605,061 B2 8/2003 VanTassel et al.
6,613,026 Bl 9/2003 Palasisetal.
6,652,489 B2 11/2003 Trockietal.
6,673,033 Bl 1/2004 Sciullietal.
6,749,026 B2 6/2004 Smith etal.
6,749,833 B2 6/2004 Raghavan et al.
6,758,828 B2 7/2004 Hammer etal.
6,796,957 B2 9/2004 Carpenter et al.
6,835,193 B2 12/2004 Epstein etal.
6,855,132 B2 2/2005 VanTassel et al.
6,892,091 Bl 5/2005 Ben-Haim et al.
6,958,093 B2 10/2005 Vaudoetal.

7,011,742 B2* 3/2006 Rosiello 210/109

7,025,876 B2* 4/2006 Shoji et al 210/198.2

2002/0010428 Al 1/2002 Vedrine et al.

2002/0082546 Al 6/2002 Crank etal.

2002/0095124 Al 7/2002 Palasisetal.

2003/0028172 Al 2/2003 Epstein etal.

OTHER PUBLICATIONS

Visipaque, Amersham Health, a division of GE Healthcare, Website (www.amershamhealth-us.com/visipaque/), As early as 1997. Aqualon, Hercules, Inc. Website, (http://www.herc.com/aqualon/), As early as 2001.

Sculptra, Aventis Pharmaceuticals Website (http://www.sculptra. com/US/Index.jsp), As early as 2002.

PuraMatrix, 3DM Inc. Website, (www.puramatrix.com), As early as 2001.

Burton, Alan C, Physiology and Biophysics of the Circulation, 2nd Edition 1972, LC#70-182003, Chapter 5.

ENSITE 3000, Endocardial Solutions Website (www. endocardialsolutions.com/patient/index.html), As early as 2000. CARLO XP System, Biosense Webster/Johnson & Johnson Website (www.jnjgateway.com), As early as 2000.

NAVI-STAR Catheter, Biosense Webster/Johnson & Johnson
Website (www.jnjgateway.com), As early as 2000.
LocaLisa Intracardiac Navigation System, Medtronic Website
(www.medtronic.com/epsystems/disclaimer.html), As early as 2000.
Realtime Position Management (RPM) System, Boston Scientific
Website (www.bostonscientific.com), As early as 2001.
U.S. Appl. No. 10/921,083, Callen et al., filed Aug. 18, 2004.
U.S. Appl. No. 10/916,946, Griffiths et al., filed Aug. 12, 2004.

* cited by examiner