Solid-state detector and optical system for microchip analyzers

(54) SOLID-STATE DETECTOR AND OPTICAL SYSTEM FOR MICROCHIP ANALYZERS

(75) Inventors: Richard A. Mathies, Moraga, CA (US); Toshihiro Kamei, Emeryville, CA (US); James R. Scherer, Richmond, CA (US); Robert A. Street,

Palo Alto, CA (US)

FOREIGN PATENT DOCUMENTS

Thrush et al., AIntegrated Bio-Fluorescence Sensor,® Stanford Photonics Research Center conference, Sep. 2001. Thrush et al., Integrated Semiconductor Fluorescent Detection System for Biochip and Biomedical Applications,® SPIE, vol. 4626, Jan. 2002.

Mizukami, Y., et al. AA Novel Microchip for Capillary Electrophoresis with Acrylic Micochannel Fabrication on Photosensor Array,® Sensors and Actuators B 81 (2002) 202-209.

Krishnan, M. et al., AA Novel Strategy for the Design of

Multiple Reaction Systems for Genetic Analysis,® Sensors

and Actuators A 95 (2002) 250-258.

Street, R.A., et al., AAmorphous Silicon Arrays Develop a

Medical Image,® IEEE Circuits and Devices (Jul. 1993)

38-42.

Webster, J.R., et al., Monolithic Capillary Electrophoresis Device with Integrated Fluorescence Detector,® Analytical Chemistry, vol. 73, No. 7, Apr. 1, 2001.

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Primary Examiner—David Porta

Assistant Examiner—Christine Sung

(74) Attorney, Agent, or Firm—Dorsey & Whitney LLP

OTHER PUBLICATIONS

Ma, E., et al., AMicrolens Arrays with Integrated Thin Film Power Monitors,® IEEE 2001 Electronic Components and Technology Conference.

Burke, David T, et al., Microfabrication Technologies for Integrated Nucleic Acid Analysis,® Genome Research, Cold Spring Harbon Laboratory Press, ISSN 1054-9803 (1997).

Burns, Mark A., An Integrated Nanoliter DNA Analysis Device,® Science® Oct. 16, 1998, vol. 282 484^187.

Thrush et al., "Integrated Semiconductor Fluorescent Detection System for Biochip and Biomedical Applications",® SPIE, vol. 4626, Jan. 2002, pp 374-379.

Integration of lasers, detectors and processing electronics in a highly compact and functional cube about 1cm3 in size® BIOMEMS 2001, May 17-18, 2001, Radisson Inn, Sunnyvale, CA.

* cited by examiner