(12) United States Patent ao) Patent No.: us 6,558,361 Bi
Yeshurun (45) Date of Patent: May 6,2003
(54) SYSTEMS AND METHODS FOR THE TRANSPORT OF FLUIDS THROUGH A BIOLOGICAL BARRIER AND PRODUCTION TECHNIQUES FOR SUCH SYSTEMS
(75) Inventor: Yehoshua Yeshurun, Haifa (IL)
(73) Assignee: Nanopass Ltd., Nalareth Illit (IL)
( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 259 days.
(21) Appl. No.: 09/589,369
(22) Filed: Jun. 8, 2000
(51) Int. CI.7 A61M 37/00
(52) U.S. CI 604/272; 604/274
(58) Field of Search 604/22, 191, 264,
604/272, 274
(56) References Cited
U.S. PATENT DOCUMENTS
3,964,482 A * 6/1976 Gerstel et al 424/449
5,697,901 A * 12/1997 Eriksson 514/44
6,256,533 Bl * 7/2001 Yuzhakov et al 604/20
A device for the transport of fluids through a biological barrier includes a number of microneedles projecting from the front face of a substrate. A conduit is associated with each of the microneedles to provide a fluid flow path for transport of fluid through a hole in the biological barrier formed by the corresponding microneedle. Each of the microneedles is configured to provide a penetrating tip, and each conduit terminates at an opening which is proximal with respect to the microneedle tip. Also described are microneedle^jased devices with integrated MEMS pumping configurations for withdrawal and/or delivery of fluids, and remote healthcare systems based on such devices.
14 Claims, 28 Drawing Sheets
