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(12) United States Patent
Murphy et al.
(io) Patent No.: (45) Date of Patent:
US 7,575,759 B2 Aug. 18, 2009
(54) TISSUE ENGINEERING SCAFFOLDS
(75) Inventors: William L. Murphy, Chicago, IL (US);
Robert G. Dennis, Ann Arbor, MI (US);
David J. Mooney, Dexter, MI (US)
(73) Assignee: The Regents of the University of
Michigan, Ann Arbor, MI (US)
( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 620 days.
(21) Appl.No.: 10/330,578
(22) Filed: Dec. 27, 2002
(65) Prior Publication Data
US 2004/0026811 Al Feb. 12, 2004
Related U.S. Application Data
(60) Provisional application No. 60/345,775, filed on Jan. 2, 2002.
(51) Int. CI.
A61F 2/00 (2006.01)
(52) U.S. CI 424/423
(58) Field of Classification Search None
See application file for complete search history.
(56) References Cited
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Primary Examiner—M P Woodward
Assistant Examiner—Casey S Hagopian
(74) Attorney, Agent, or Firm—Medlen & Carroll, LLP
The present invention relates to methods and compositions for the production of scaffolds, such scaffolds to be used for a variety of purposes, including tissue engineering. More specifically, the present invention relates to the use of fused crystals, such as fused salt crystals to form a framework. The methods for producing the scaffolds of this invention improve the porosity, interconnectivity and ease of manufacture as compared to prior art methods.
16 Claims, 15 Drawing Sheets
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