Laser/sensitizer assisted immunotherapy

United States Patent [w]

Nordquist et al.

US006149671A [ii] Patent Number: 6,149,671 [45] Date of Patent: *Nov. 21,2000

[54] LASER/SENSITIZER ASSISTED IMMUNOTHERAPY

[75] Inventors: Robert E. Nordquist, Oklahoma City;

Wei R. Chen, Norman; Raoul
Carubelli, Oklahoma City, all of Okla.

[73] Assignee: Wound Healings of Oklahoma,

Oklahoma City, Okla.

[ * ] Notice: This patent is subject to a terminal disclaimer.

[21] Appl. No.: 08/967,366 [22] Filed: Nov. 7, 1997

Related U.S. Application Data

[63] Continuation of application No. 08/416,158, Apr. 4, 1995, abandoned.

[51] Int. C I. A61M 5/06

[52] U.S. CI 607/89; 606/3; 606/13;

607/88; 607/92; 604/20

[58] Field of Search 606/2, 3-16; 607/88-92;

604/20

[56] References Cited

U.S. PATENT DOCUMENTS

A method for treating a neoplasm, such as a malignant tumor, in humans and other animals, is disclosed. A chromophore and an immunoadjuvant are introduced into the neoplasm. The neoplasm is then lased at an irradiance sufficient to induce neoplastic cellular destruction and to stimulate the self-immunological defense system against neoplastic cellular multiplication.

17 Claims, 5 Drawing Sheets

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