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(12) United States Patent

Szeto et al.

(io) Patent No.: (45) Date of Patent:

US 7,704,954 B2 Apr. 27, 2010

(54) METHOD AND CARRIER COMPLEXES FOR DELIVERING MOLECULES TO CELLS

(75) Inventors: Hazel H. Szeto, New York, NY (US);

Kesheng Zhao, Jackson Heights, NY
(US); Hugh D. Robertson, New York,
NY (US); Alex V. Birk, Woodhaven, NY
(US)

(73) Assignee: Cornell Research Foundation, Inc.,

Ithaca, NY (US)

( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 1215 days.

(21) Appl.No.: 10/838,135

(22) Filed: May 3, 2004

(65) Prior Publication Data

US 2005/0158373 Al Jul. 21, 2005

Related U.S. Application Data

(60) Provisional application No. 60/467,516, filed on May 1,2003.

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Schiller, et al., "Opioid peptide analogs with novel activity profiles as potential therapeutic agents for use in analgesia", Peptide SciencePresent and Future, Proc. Int. Pept. Symp., 1st, Y. Shimonishi (ed), 1999, pp. 665-669.

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Net Charge Opiod Tetrapepdide", Journal of Pharmacology and

Experimental Therapeutics 2003, 304(l):425-432.

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Exposure to a Highly Selective |3-Opioid Peptide Agonist: Role of

8-Opioid Receptors," J. Pharma. Exper. Thera. 2002, 302(1) 188

196.

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(Continued)

Primary Examiner—Anish Gupta

(74) Attorney, Agent, or Firm—Foley & Lardner LLP

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OTHER PUBLICATIONS

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* cited by examiner

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