(12) UIllt€d States Patent (10) Patent No.: US 7,961,845 B2 Gertner et al. 45 Date of Patent: Jun. 14 2011 9 (54) ORTHOVOLTAGE RADIOTHERAPY 4,710,193 A 12/1987 V011< 4,718,418 A 1/1988 L’Esperance, Jr. (75) Inventors: Michael Gertner, Menlo Park, CA 4’8l7’432 A 4/1989 Wallace et al' (US); Steven D. Hansen, Concord, CA (Continued) (US) FOREIGN PATENT DOCUMENTS (73) Assignee: Oraya Therapeutics, Inc., Newark, CA W0 W0 2001/26591 4/2001 (US) (Continued) ( * ) Notice: Subject to any disclaimer, the term of this OTHER PUBLICATIONS Paieiii is extended or adjusted under 35 Bailey, Edgar D., CHP, Chief Radiologic Health Branch, “Syllabus U.S.C. 154(0) by 0 days. on Radiography Radiation Protection, Filtration Regulatory Requirements,” California Department of Health and Human Services, pp. (21) Appl. No.: 12/497,437 11-12 (2004). (22) Filed: Jul. 2, 2009 (Continued) . . . Primary Examiner 4 Allen C. Ho 65 P P bl t D t ( ) nor u lea Ion a a (74) Attorney, Agent, or Firm 4McDermott Will & Emery US 2010/0002837 A1 Jan. 7, 2010 LLP; James W. Hill; M. Todd Hales Related U.S. Application Data (57) ABSTRACT (63) Continuation of application No. 11/956,295, filed on A iadiosuigeiy System is desciiiied that is Configured io Dec‘ 13, 2007, now Pat‘ NO_ 7,620,141 deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, rnflammatory ocular d1sor(60) Pr0ViSi0I1a1 application N0~ 60/869,872, filed 011 D60 ders are treated, specifically macular degeneration. In some 13, 2006, Pf0ViSi0I1a1 application N0~ 60/922,741, embodiments, other disorders or tissues of a body are treated filed on Apr. 9, 2007, provisional application N0- with the dose of radiation. In some embodiments, the target 60/933,220, filed OI1 -11111-4, 2007- tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues (51) Int- Ci- inside the global coordinate system lead to direction of an A61N 5/10 (2006-Oi) automated positioning system that is directed based on the A61B 6/08 (2006-Oi) target tissues within the coordinate system. In some embodi(52) U.S. Cl. ......................... .. 378/65; 378/205; 378/206 ments, a treatment plan is utilized in which beam energy and (58) Field of Classification Search .................. .. 378/65, direction and duration of time for treatment is determined for 378/205, 206 a specific disease to be treated and/or structures to be avoided. See application file for complete search history. In some embodiments, a fiducial markeris used to identify the location of the target tissues. In some embodiments, radiody(56) References Cited namic therapy is described in which radiosurgery is used in
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