Irrigation solution and methods for inhibition of tumor cell adhesion, pain ...

(21) Appl. No.: 09/658,815

(22) Filed: Sep. 11, 2000

Related U.S. Application Data

(63) Continuation-in-part of application No. 09/072,913, filed on May 4, 1998, now Pat. No. 6,261,279, which is a continuation of application No. 08/670,699, filed on Jun. 26, 1996, now Pat. No. 5,820,583, which is a continuation-in-part of application No. PCT/US95/16028, filed on Dec. 12, 1995, which is a continuation-in-part of application No. 08/353, 775, filed on Dec. 12, 1994, now abandoned.

(60) Provisional application No. 60/162,416, filed on Oct. 28, 1999.

(51) Int. CI.7 A61K 38/00; A61K 31/70;

A61K 31/55; A61K 31/54; A61K 31/495;

A61K 31/505

(52) U.S. CI 514/12; 514/25; 514/217

514/226.2; 514/253; 514/254.06; 514/258 514/259; 514/280; 514/288; 514/317; 514/327 514/353; 514/356; 514/397; 514/413; 514/415 514/509; 514/619; 514/654; 514/680

(58) Field of Search 514/12, 25, 217,

514/226.2, 253, 254.06, 258, 259, 280, 288, 317, 327, 353, 356, 397, 413, 415, 509, 619, 654, 680

OTHER PUBLICATIONS

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Naesh, O., et al., "Platelet activation in mental stress," Clin. Physiol. 13:299-307 (1993).

(List continued on next page.)

Primary Examiner—William R. A. Jarvis

(74) Attorney, Agent, or Firm—Christensen O'Connor

Johnson Kindness PLLC

OTHER PUBLICATIONS

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Gastpar, H., "The Inhibition of Cancer Cell Stickiness by the Methylxanthine Derivative Pentoxifylline (BL 191)," Thrombosis Research 5:277-289 (1974). Lee et al., "Peritoneal Irrigation with Povidone-Iodine Solution After Laparoscopic Assisted Splenectomy Significantly Decreases Port-Tumor Recurrence in a Murine Model," Dis Colon Rectum 42(3):319-326 (1999). Lapierre et al., "Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties," Glycobiology 6(3):355-366 (1966). Engelberg, H., "Actions of Heparin That May Effect the Malignant Process," Cancer 85(2):257-272 (1999). Neuhaus et al., "Experimental study of the effect of intraperitoneal heparin on tumour implantation following laparoscope" British J. Surgery 86:400-404 (1999). Jacobi et al., "Inhibition of Peritoneal Tumor Cell Growth and Implantation in Laparoscopic Surgery in a Rat Model," American J. Surgery® 174:359-363 (1997). Whalen, Giles E, and Donald E. Ingber, "Inhibition of Tumor-Cell Attachment to Extracellular Matrix as a Method for Preventing Tumor Recurrence in a Surgical Wound," Ann. Surg. 210(6):758-764 (1989).

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