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(12) UIllt€d States Patent (10) Patent No.: US 8,170,305 B2 Laidlaw et al. (45) Date of Patent: May 1, 2012 (54) QUANTITATIVE TRACT-OF-INTEREST 6,591,004 B1 * 7/2003 VanEssen et al. ........... .. 382/154 METRICS FOR WHITE MATTER INTEGRITY E; j Eu_CC1l1leta1~t ~l~ ~~~~~ ~~ , , a1 aw e a . BASED ON DIFFUSION TENSOR MRI DATA 7,602,180 B2 * 10/2009 McGraw .......... .. 324/307 _ _ _ 7,672,790 B2 * 3/2010 McGraw et al. 702/19 (75) Inventorsl Davld H Laldlaw, Barnngton, RI (US); 7,881,878 B2 * 2/2011 Burrus 61 al. .. 702/28 Song Zhang, Starkville, MS (US); 7,928,728 B2 * 4/2011 Wedeen ....... .. 324/309 Stephanie Y*‘‘'““ “*3 Needham’ MA 533%/8532358 ii: @533? Ealiilaw ‘I al 333/III . ' 3.1 awe 3.. Stephen Correla’ Cranston’ RI 2010/0135560 A1* 6/2010 EIIIDIGIOII 61 al. ........... .. 382/131 OTHER PUBLICATIONS (73) Assignee: Brown University, Providence, RI (US) _ _ _ _ _ “From drffusron tractography to quantrtatrve whrte matter tract mea( * ) Notice: Subject to any disclaimer, the term of this sures? a reproducibility study”, Ciccflfellii 0» GU11, Nemolmage 18 patent is extended or adjusted under 35 (2003), 348-359 U_S_C_ 154 b b 1162 da S_ “Exploring Connectivity of the Brain’s White Matter with Dynamic ( ) y y Queries”, Sherbondy, A., et al, IEEE Transactions on Visualization (21) App1_ NO_; 11/975,416 and Computer Graphics, vol. 11, No. 4, Jul./Aug. 2005. (22) Filed: 061. 19, 2007 (Continued) (65) Prior Publication D at a Primary Examiner * David A Vanore~ . Us 2008/0205733 A1 A 28 2008 (74) Attorney, Agent, or Firm * Harrmgton & Sm1th ug. , 57 ABSTRACT Related U.S. Application Data ffh) 1 b d_ f h_ _ _ 1 1 _ _ _ _ e exemp ary em o 1ments o t is 1nvent1on re ate at east (60) I1IgO‘;82)O6na1 apphcanon NO' 60/852,922’ filed on Oct in part to a method, apparatus and system to characterize ’ ' white matter, such as for detecting a presence of a white (51) Int Cl matter impairment. An exemplary method to characterize I I white matter includes identifying at least one tract of interest G01N31/00 (2006.01) TOI . th b . f b. t f. t t th t t f. t t (52) U.S. Cl. ...... .. 382/128; 382/154; 324/309; 324/312; £1 . )1“ ‘: $1“ 0 anslg Jec O In efes ’ hi rac tot “;i§reS_ 345/419; 345/424; 345/442; 600/410; 702/28 datV1ng_a_Se O S €eaI{n e§triPreSten ltng W if mat Sr em, (58) Field 61 Classification Search ................ .. 382/128, .‘I't‘I'r(I1n1I1.1tI111gt; 5: °tq;,12Int1 a lrethrac Otgriip y T.“ 155°‘ 382/154; 324/309, 312; 345/419, 424, 442; C12‘ e W1 S rac .0 In em ’. e Se 0 qua“ 1 a We ra°' 600/410, 702/28 tography metncs having a plurality of members; and comparSee application file for Complete Search hiStO’ry~ ing at least one member of the determined set of quantitative tractography metrics to a corresponding member of a refer(56) References Cited ence set of quantitative tractography metrics, or comparison
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AVERAGE LENGTH: THE TOTAL SUMMED LENGTH OF
ALL STREAMTUBES DIVIDED BUY THE NUMBER
OF STREAMTUBES IN A TRACT OF INTEREST
TABLE 2: RESULTS OF THE REPRODUCIBILITY STUDY (MEAN iSD)
SEED NS TL(mm) TWL(rr'1m) 1.70 mm3 7895 :t 11 108978 =8 844 26874 :t 258 c0v=.1% COV=.8% c0v=1.0% 0.85 mm~’* 11858 :1: 28 188752 :1: 828 88889 1 245 cov=.2% COV=.8% cov=.sz 0.64 mm3 18408 :t 40 151180 1 708 88881 1 157 COV=.3% COV=.8% c0\/=.4%
NOTE: CELL VALUES ARE CALCULATED FROM SEVEN MODELS AT EACH SEEDING PARAMETER
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