(12) Ullltfild States Patent (10) Patent No.: US 7,966,131 B2 Chen et al. (45) Date of Patent: *Jun. 21, 2011 (54) ANALYTE SENSORS AND METHODS (56) References Cited (75) Inventors: Ting Chen, Cedar Park, TX (U S); U_$_ PATENT DQCUMENTS Benjamin J. Feldman, Oakland, CA 5 620 466 A ,,, 4/1997 Haefner et 31‘ “““““““““ “ 607/5 (US) 5,824,936 A * 10/1998 DuPuis G131. ................ .. 84/663 _ 6,120,676 A 9/2000 Heller et al. (73) Assignee: Abbott Diabetes Care Inc., Alameda, 6,338,790 B1 1/2002 Feldman et al. CA (US) 6,444,115 B1 9/2002 Hodges et al. 6,579,690 B1 6/2003 Bonnecaze et al. ( * ) Notice: Subject to any disclaimer, the term ofthis 2002/0148739 A2 * 10/2002 Lramos et al. .............. .. 205/787 patent is extended er adjusted under 35 2004/0079652 A1 4/2004 Vreeke et al. U-S-C l54(b) by 0 days OTHER PUBLICATIONS This patent is Subject to a terminal dis" Budnikov G.K. Journal of Analytical Chemistry vol. 55 No. 11 Claim“ 2000, pp. 1014-1023* _ Wang et al. Database Caplus, DN 961154502 (Analytical Chemistry (21) Appl.No.. 12/463,219 (1982), 54(5), 861_8l4),,, May 8, * ejted examiner (65) Pi'i°i' Piibiicatioii Data Primary Examiner — Michael Borin Us 2009/0229996 A1 gep_ 17, 2009 (74) Attorney, Agent, or Firm —Edward J. Baba; Khin K. Chin; Bozicevic, Field & Francis LLP Related U.S. Application Data 57 ABSTRACT (63) Continuation of application No. 11/555,167, filed on ( ) _ _ _ QC; 31, 2006, now Pat NO_ 7,322,551 Methods of determ1n1ng analyte concentration. The methods use a fraction of the predicted total charge, from analyte (51) Int. Cl. electrolysis, instead of using time, for detennination of a data G01N 2 7/406 (2006-01) collection endpoint. The total charge is then extrapolated G01N31/00 (2006~0i) from the data collection endpoint. The analyte concentration (52) U.S. CI. ...... .. 702/23, 702/19, 205/792, 204/403.03 is detennined ffem the tetal charge (58) Field of Classification Search ...................... .. None See application file for complete search history. 8 Claims, 3 Drawing Sheets 40 35Measurement Dal 3025E E 5 20U
