(12) United States Patent (io) Patent No.: US 6,883,222 B2
Landau (45) Date of Patent: Apr. 26,2005
(54) DRUG CARTRIDGE ASSEMBLY AND METHOD OF MANUFACTURE
(75) Inventor: Sergio Landau, Laguna Niguel, CA (US)
(73) Assignee: Biqject Inc., Tualatin, OR (US)
( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 22 days.
(21) Appl. No.: 10/272,689
(22) Filed: Oct. 16, 2002
(65) Prior Publication Data
US 2004/0074076 Al Apr. 22, 2004
(51) Int. C I. B23P 21/00
(52) U.S. CI 29/469; 53/426; 53/432;
(58) Field of Search 29/428, 429, 458,
29/469; 53/425, 426, 432, 511; 604/403
A method of manufacture for a drug cartridge assembly. The method includes providing a drug cartridge, providing a nozzle sub-assembly, and sterilizing the drug cartridge and nozzle sub-assembly. The method further includes assembling the drug cartridge and nozzle sub-assembly together in a configuration that enables ejection of liquid out of the drug cartridge through the nozzle sub-assembly. The method further includes filling the drug cartridge with a liquid, such as an injectable drug. The method may include separate sterilization of the drug cartridge and nozzle sub-assembly, using different sterilization processes. Portions of the method may be performed prior to sterilization within a first cleanroom, with subsequent steps being performed in a second cleanroom having a substantially lower particulateper-volume rating than the first cleanroom.
14 Claims, 2 Drawing Sheets