Anti-IGF-I receptor antibody

FIGURE 4

Inhibition of IGF-I-Stimulated Autophosphorylation of IGF-I Receptor in MCF-7 Cells by EM164 Antibody

FIGURE 5

Inhibition of IGF-I-Stimulated IRS-1 -Phosphorylation in MCF-7 Cells by EM 164 antibody

FIGURE 6

Inhibition of IGF-I-Stimulated Signal Transduction in SaOS-2 Cells by EM164 Antibody

•IGF-I +IGF-I Blot
(50 ng/mL)

0 0 5 fMTM

(ug/ml)

phospho-Akt (S473)

phospho-Erk

pan-Erk
(reblot after
phospho-Erk blot)