Livrables Websites, patent fillings, videos etc. (1) Promotional materials including a dedicated website Publications Peer reviewed articles (237) Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis Auteurs: Barbara Schormair, Chen Zhao, Steven Bell, Erik Tilch, Aaro V Salminen, Benno Pütz, Yves Dauvilliers, Ambra Stefani, Birgit Högl, Werner Poewe, David Kemlink, Karel Sonka, Cornelius G Bachmann, Walter Paulus, Claudia Trenkwalder, Wolfgang H Oertel, Magdolna Hornyak, Maris Teder-Laving, Andres Metspalu, Georgios M Hadjigeorgiou, Olli Polo, Ingo Fietze, Owen A Ross, Zbigniew Wszolek, Adam S Butter Publié dans: The Lancet Neurology, Numéro 16/11, 2017, Page(s) 898-907, ISSN 1474-4422 Éditeur: The Lancet Publishing Group DOI: 10.1016/S1474-4422(17)30327-7 Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis Auteurs: Linda M. Polfus, Rajiv K. Khajuria, Ursula M. Schick, Nathan Pankratz, Raha Pazoki, Jennifer A. Brody, Ming-Huei Chen, Paul L. Auer, James S. Floyd, Jie Huang, Leslie Lange, Frank J.A. van Rooij, Richard A. Gibbs, Ginger Metcalf, Donna Muzny, Narayanan Veeraraghavan, Klaudia Walter, Lu Chen, Lisa Yanek, Lewis C. Becker, Gina M. Peloso, Aoi Wakabayashi, Mart Kals, Andres Metspalu, Tõnu Publié dans: The American Journal of Human Genetics, Numéro 99/3, 2016, Page(s) 785, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2016.08.002 Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries Auteurs: Seyedeh M. Zekavat, Sanni Ruotsalainen, Robert E. Handsaker, Maris Alver, Jonathan Bloom, Timothy Poterba, Cotton Seed, Jason Ernst, Mark Chaffin, Jesse Engreitz, Gina M. Peloso, Ani Manichaikul, Chaojie Yang, Kathleen A. Ryan, Mao Fu, W. Craig Johnson, Michael Tsai, Matthew Budoff, Ramachandran S. Vasan, L. Adrienne Cupples, Jerome I. Rotter, Stephen S. Rich, Wendy Post, Braxton D. Mitchell, Adol Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-018-04668-w Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions Auteurs: Dmitry Shungin, Wei Q. Deng, Tibor V. Varga, Jian'an Luan, Evelin Mihailov, Andres Metspalu, Andrew P. Morris, Nita G. Forouhi, Cecilia Lindgren, Patrik K. E. Magnusson, Nancy L. Pedersen, Göran Hallmans, Audrey Y. Chu, Anne E. Justice, Mariaelisa Graff, Thomas W. Winkler, Lynda M. Rose, Claudia Langenberg, L. Adrienne Cupples, Paul M. Ridker, Nicholas J. Wareham, Ken K. Ong, Ruth J. F. Loos, Dan Publié dans: PLOS Genetics, Numéro 13/6, 2017, Page(s) e1006812, ISSN 1553-7390 Éditeur: Public Library of Science DOI: 10.1371/journal.pgen.1006812 Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy Auteurs: Sean G. Byars, Qin Qin Huang, Lesley-Ann Gray, Andrew Bakshi, Samuli Ripatti, Gad Abraham, Stephen C. Stearns, Michael Inouye Publié dans: PLOS Genetics, Numéro 13/6, 2017, Page(s) e1006328, ISSN 1553-7404 Éditeur: PLOS DOI: 10.1371/journal.pgen.1006328 Smoking-related general and cause-specific mortality in Estonia Auteurs: Gea Kõks, Krista Fischer, Sulev Kõks Publié dans: BMC Public Health, Numéro 18/1, 2018, ISSN 1471-2458 Éditeur: BioMed Central DOI: 10.1186/s12889-017-4590-3 Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa Auteurs: Laramie Duncan, Zeynep Yilmaz, Helena Gaspar, Raymond Walters, Jackie Goldstein, Verneri Anttila, Brendan Bulik-Sullivan, Stephan Ripke, Laura Thornton, Anke Hinney, Mark Daly, Patrick F. Sullivan, Eleftheria Zeggini, Gerome Breen, Cynthia M. Bulik, Laramie Duncan, Zeynep Yilmaz, Héléna Gaspar, Raymond Walters, Jackie Goldstein, Verneri Anttila, Brendan Bulik-Sullivan, Stephan Ripke, Roger Adan, Publié dans: American Journal of Psychiatry, Numéro 174/9, 2017, Page(s) 850-858, ISSN 0002-953X Éditeur: American Psychiatric Publishing, Inc. DOI: 10.1176/appi.ajp.2017.16121402 C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis Auteurs: Kaido Lepik, Tarmo Annilo, Viktorija Kukuškina, Kai Kisand, Zoltán Kutalik, Pärt Peterson, Hedi Peterson Publié dans: PLOS Computational Biology, Numéro 13/9, 2017, Page(s) e1005766, ISSN 1553-7358 Éditeur: PLOS DOI: 10.1371/journal.pcbi.1005766 Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria Auteurs: Felix Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M. Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H. Mullin, Bronwyn G. A. Stuckey, Timothy D. Spector, Scott G. Wilson, Mark O. Goodarzi, Lea Davis, Barbara Obermayer-Pietsc Publié dans: PLOS Genetics, Numéro 14/12, 2018, Page(s) e1007813, ISSN 1553-7404 Éditeur: PLOS DOI: 10.1371/journal.pgen.1007813 An interaction map of circulating metabolites, immune gene networks, and their genetic regulation Auteurs: Artika P. Nath, Scott C. Ritchie, Sean G. Byars, Liam G. Fearnley, Aki S. Havulinna, Anni Joensuu, Antti J. Kangas, Pasi Soininen, Annika Wennerström, Lili Milani, Andres Metspalu, Satu Männistö, Peter Würtz, Johannes Kettunen, Emma Raitoharju, Mika Kähönen, Markus Juonala, Aarno Palotie, Mika Ala-Korpela, Samuli Ripatti, Terho Lehtimäki, Gad Abraham, Olli Raitakari, Veikko Salomaa, Markus Publié dans: Genome Biology, Numéro 18/1, 2017, ISSN 1474-760X Éditeur: BMC DOI: 10.1186/s13059-017-1279-y Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution Auteurs: Reedik Mägi, Momoko Horikoshi, Tamar Sofer, Anubha Mahajan, Hidetoshi Kitajima, Nora Franceschini, Mark I. McCarthy, Andrew P. Morris Publié dans: Human Molecular Genetics, Numéro 26/18, 2017, Page(s) 3639-3650, ISSN 0964-6906 Éditeur: Oxford University Press DOI: 10.1093/hmg/ddx280 Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts Auteurs: Juho Tynkkynen, Vincent Chouraki, Sven J. van der Lee, Jussi Hernesniemi, Qiong Yang, Shuo Li, Alexa Beiser, Martin G. Larson, Katri Sääksjärvi, Martin J. Shipley, Archana Singh-Manoux, Robert E. Gerszten, Thomas J. Wang, Aki S. Havulinna, Peter Würtz, Krista Fischer, Ayse Demirkan, M. Arfan Ikram, Najaf Amin, Terho Lehtimäki, Mika Kähönen, Markus Perola, Andres Metspalu, Antti J. Kangas, P Publié dans: Alzheimer's & Dementia, Numéro 14/6, 2018, Page(s) 723-733, ISSN 1552-5260 Éditeur: Elsevier BV DOI: 10.1016/j.jalz.2018.01.003 Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia Auteurs: Maris Alver, Marili Palover, Aet Saar, Kristi Läll, Seyedeh Maryam Zekavat, Neeme Tõnisson, Liis Leitsalu, Anu Reigo, Tiit Nikopensius, Tiia Ainla, Mart Kals, Reedik Mägi, Stacey B. Gabriel, Jaan Eha, Eric S. Lander, Alar Irs, Anthony Philippakis, Toomas Marandi, Pradeep Natarajan, Andres Metspalu, Sekar Kathiresan, Tõnu Esko Publié dans: Genetics in Medicine, Numéro Published Online: 01 October 2018, 2018, Page(s) 1-0, ISSN 1098-3600 Éditeur: Lippincott Williams & Wilkins Ltd. DOI: 10.1038/s41436-018-0311-2 Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations Auteurs: Clara Barrios, Jonas Zierer, Peter Würtz, Toomas Haller, Andres Metspalu, Christian Gieger, Barbara Thorand, Christa Meisinger, Melanie Waldenberger, Olli Raitakari, Terho Lehtimäki, Sol Otero, Eva Rodríguez, Juan Pedro-Botet, Mika Kähönen, Mika Ala-Korpela, Gabi Kastenmüller, Tim D. Spector, Julio Pascual, Cristina Menni Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/s41598-018-33507-7 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits Auteurs: Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P. Cabrera, Ibrahim Karaman, Fu Liang Ng, Marina Evangelou, Katarzyna Witkowska, Evan Tzanis, Jacklyn N. Hellwege, Ayush Giri, Digna R. Velez Edwards, Yan V. Sun, Kelly Cho, J. Michael Gaziano, Peter W. F. Wilson, Philip S. Tsao, Csaba P. Kovesdy, Tonu Esko, Reedi Publié dans: Nature Genetics, Numéro 50/10, 2018, Page(s) 1412-1425, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/s41588-018-0205-x Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes Auteurs: Douglas M. Ruderfer, Stephan Ripke, Andrew McQuillin, James Boocock, Eli A. Stahl, Jennifer M. Whitehead Pavlides, Niamh Mullins, Alexander W. Charney, Anil P.S. Ori, Loes M. Olde Loohuis, Enrico Domenici, Arianna Di Florio, Sergi Papiol, Janos L. Kalman, Vassily Trubetskoy, Rolf Adolfsson, Ingrid Agartz, Esben Agerbo, Huda Akil, Diego Albani, Margot Albus, Martin Alda, Madeline Alexander, Ney All Publié dans: Cell, Numéro 173/7, 2018, Page(s) 1705-1715.e16, ISSN 0092-8674 Éditeur: Cell Press DOI: 10.1016/j.cell.2018.05.046 Genetic risk scores and family history as predictors of schizophrenia in Nordic registers Auteurs: Y. Lu, J. G. Pouget, O. A. Andreassen, S. Djurovic, T. Esko, C. M. Hultman, A. Metspalu, L. Milani, T. Werge, P. F. Sullivan Publié dans: Psychological Medicine, Numéro 48/07, 2018, Page(s) 1201-1208, ISSN 0033-2917 Éditeur: Cambridge University Press DOI: 10.1017/s0033291717002665 GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia Auteurs: Joëlle A. Pasman, Karin J. H. Verweij, Zachary Gerring, Sven Stringer, Sandra Sanchez-Roige, Jorien L. Treur, Abdel Abdellaoui, Michel G. Nivard, Bart M. L. Baselmans, Jue-Sheng Ong, Hill F. Ip, Matthijs D. van der Zee, Meike Bartels, Felix R. Day, Pierre Fontanillas, Sarah L. Elson, Harriet de Wit, Lea K. Davis, James MacKillop, Jaime L. Derringer, Susan J. T. Branje, Catharina A. Hartman, Andre Publié dans: Nature Neuroscience, Numéro 21/9, 2018, Page(s) 1161-1170, ISSN 1097-6256 Éditeur: Nature Publishing Group DOI: 10.1038/s41593-018-0206-1 Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length Auteurs: Triin Laisk, Viktorija Kukuškina, Duncan Palmer, Samantha Laber, Chia-Yen Chen, Teresa Ferreira, Nilufer Rahmioglu, Krina Zondervan, Christian Becker, Jordan W Smoller, Margaret Lippincott, Andres Salumets, Ingrid Granne, Stephanie Seminara, Benjamin Neale, Reedik Mägi, Cecilia M Lindgren Publié dans: Human Molecular Genetics, Numéro 27(24), 2018, Page(s) 4323-4332, ISSN 0964-6906 Éditeur: Oxford University Press DOI: 10.1093/hmg/ddy317 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals Auteurs: James J. Lee, Robbee Wedow, Aysu Okbay, Edward Kong, Omeed Maghzian, Meghan Zacher, Tuan Anh Nguyen-Viet, Peter Bowers, Julia Sidorenko, Richard Karlsson Linnér, Mark Alan Fontana, Tushar Kundu, Chanwook Lee, Hui Li, Ruoxi Li, Rebecca Royer, Pascal N. Timshel, Raymond K. Walters, Emily A. Willoughby, Loïc Yengo, Maris Alver, Yanchun Bao, David W. Clark, Felix R. Day, Nicholas A. Furlotte, Peter Publié dans: Nature Genetics, Numéro 50/8, 2018, Page(s) 1112-1121, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/s41588-018-0147-3 Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders Auteurs: Symen Ligthart, Ahmad Vaez, Urmo Võsa, Maria G. Stathopoulou, Paul S. de Vries, Bram P. Prins, Peter J. Van der Most, Toshiko Tanaka, Elnaz Naderi, Lynda M. Rose, Ying Wu, Robert Karlsson, Maja Barbalic, Honghuang Lin, René Pool, Gu Zhu, Aurélien Macé, Carlo Sidore, Stella Trompet, Massimo Mangino, Maria Sabater-Lleal, John P. Kemp, Ali Abbasi, Tim Kacprowski, Niek Verweij, Albert V. Smith, Ta Publié dans: The American Journal of Human Genetics, Numéro 103/5, 2018, Page(s) 691-706, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2018.09.009 Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene Auteurs: N Pervjakova, V Kukushkina, T Haller, S Kasela, A Joensuu, K Kristiansson, T Annilo, M Perola, V Salomaa, P Jousilahti, A Metspalu, R Mägi Publié dans: Biomarkers in Medicine, Numéro 12/5, 2018, Page(s) 439-446, ISSN 1752-0363 Éditeur: Future Medicine Ltd. DOI: 10.2217/bmm-2018-0020 Deep-coverage whole genome sequences and blood lipids among 16,324 individuals Auteurs: Pradeep Natarajan, Gina M. Peloso, Seyedeh Maryam Zekavat, May Montasser, Andrea Ganna, Mark Chaffin, Amit V. Khera, Wei Zhou, Jonathan M. Bloom, Jesse M. Engreitz, Jason Ernst, Jeffrey R. O’Connell, Sanni E. Ruotsalainen, Maris Alver, Ani Manichaikul, W. Craig Johnson, James A. Perry, Timothy Poterba, Cotton Seed, Ida L. Surakka, Tonu Esko, Samuli Ripatti, Veikko Salomaa, Adolfo Correa, Ramacha Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-018-05747-8 The risk-treatment paradox in non-ST-elevation myocardial infarction patients according to their estimated GRACE risk Auteurs: Aet Saar, Toomas Marandi, Tiia Ainla, Krista Fischer, Mai Blöndal, Jaan Eha Publié dans: International Journal of Cardiology, Numéro 272, 2018, Page(s) 26-32, ISSN 0167-5273 Éditeur: Elsevier BV DOI: 10.1016/j.ijcard.2018.08.015 Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries Auteurs: Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla, Xiuqing Guo, Nora Franceschini, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K. Musani, Changwei Li, Amy R. Bentley, Michael R. Brown, Karen Schwander, Melissa A. Richard, Raymond Noordam, Hugues Aschard, Traci M. Bartz, Lawrence F. Bielak, Rajkumar Dorajoo, Virginia Fisher, F Publié dans: PLOS ONE, Numéro 13/6, 2018, Page(s) e0198166, ISSN 1932-6203 Éditeur: Public Library of Science DOI: 10.1371/journal.pone.0198166 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk Auteurs: Nicola Pirastu, Peter K. Joshi, Paul S. de Vries, Marilyn C. Cornelis, Paul M. McKeigue, NaNa Keum, Nora Franceschini, Marco Colombo, Edward L. Giovannucci, Athina Spiliopoulou, Lude Franke, Kari E. North, Peter Kraft, Alanna C. Morrison, Tõnu Esko, James F. Wilson Publié dans: Nature Communications, Numéro 8/1, 2017, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-017-01490-8 Multi-ethnic genome-wide association study for atrial fibrillation Auteurs: Carolina Roselli, Mark D. Chaffin, Lu-Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, Christine M. Albert, Peter Almgren, Alvaro Alonso, Christopher D. Anderson, Krishna G. Aragam, Dan E. Arking, John Barnard, Traci M. Bartz, Emelia J. Benjamin, Nathan A. Bihlmeyer, Joshua C. Bis, Heather L. Bloom, Eric Boerwinkle, Erwin B. Bottinger, Jennifer A. Brody, Hugh Calkins, Archie Campbell, Thomas P. Ca Publié dans: Nature Genetics, Numéro 50/9, 2018, Page(s) 1225-1233, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/s41588-018-0133-9 Pharmacogenomic Biomarkers for Improved Drug Therapy—Recent Progress and Future Developments Auteurs: Volker M. Lauschke, Lili Milani, Magnus Ingelman-Sundberg Publié dans: The AAPS Journal, Numéro 20/1, 2018, Page(s) 1-16, ISSN 1550-7416 Éditeur: Springer New York DOI: 10.1208/s12248-017-0161-x Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland Auteurs: Alicia R. Martin, Konrad J. Karczewski, Sini Kerminen, Mitja I. Kurki, Antti-Pekka Sarin, Mykyta Artomov, Johan G. Eriksson, Tõnu Esko, Giulio Genovese, Aki S. Havulinna, Jaakko Kaprio, Alexandra Konradi, László Korányi, Anna Kostareva, Minna Männikkö, Andres Metspalu, Markus Perola, Rashmi B. Prasad, Olli Raitakari, Oxana Rotar, Veikko Salomaa, Leif Groop, Aarno Palotie, Benjamin M. Neale, Publié dans: The American Journal of Human Genetics, Numéro 102/5, 2018, Page(s) 760-775, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2018.03.003 Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients Auteurs: Matthew T. Patrick, Philip E. Stuart, Kalpana Raja, Johann E. Gudjonsson, Trilokraj Tejasvi, Jingjing Yang, Vinod Chandran, Sayantan Das, Kristina Callis-Duffin, Eva Ellinghaus, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Hyun M. Kang, Gerald G. Krueger, Henry W. Lim, Proton Rahman, Cheryl F. Rosen, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, John J. Voorhees, Gonçalo R. Abecasis, Da Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-018-06672-6 Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease-associated variants Auteurs: Lucilla Pizzo, Matthew Jensen, Andrew Polyak, Jill A. Rosenfeld, Katrin Mannik, Arjun Krishnan, Elizabeth McCready, Olivier Pichon, Cedric Le Caignec, Anke Van Dijck, Kate Pope, Els Voorhoeve, Jieun Yoon, Paweł Stankiewicz, Sau Wai Cheung, Damian Pazuchanics, Emily Huber, Vijay Kumar, Rachel L. Kember, Francesca Mari, Aurora Curró, Lucia Castiglia, Ornella Galesi, Emanuela Avola, Teresa Mattina, Publié dans: Genetics in Medicine, Numéro Published Online: 07 September 2018, 2018, Page(s) 1-10, ISSN 1098-3600 Éditeur: Lippincott Williams & Wilkins Ltd. DOI: 10.1038/s41436-018-0266-3 Genetic influence on social outcomes during and after the Soviet era in Estonia Auteurs: Kaili Rimfeld, Eva Krapohl, Maciej Trzaskowski, Jonathan R. I. Coleman, Saskia Selzam, Philip S. Dale, Tonu Esko, Andres Metspalu, Robert Plomin Publié dans: Nature Human Behaviour, Numéro 2/4, 2018, Page(s) 269-275, ISSN 2397-3374 Éditeur: PMC DOI: 10.1038/s41562-018-0332-5 Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes Auteurs: Anubha Mahajan, Jennifer Wessel, Sara M. Willems, Wei Zhao, Neil R. Robertson, Audrey Y. Chu, Wei Gan, Hidetoshi Kitajima, Daniel Taliun, N. William Rayner, Xiuqing Guo, Yingchang Lu, Man Li, Richard A. Jensen, Yao Hu, Shaofeng Huo, Kurt K. Lohman, Weihua Zhang, James P. Cook, Bram Peter Prins, Jason Flannick, Niels Grarup, Vassily Vladimirovich Trubetskoy, Jasmina Kravic, Young Jin Kim, Denis V. Publié dans: Nature Genetics, Numéro 50/4, 2018, Page(s) 559-571, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/s41588-018-0084-1 Reply to ‘Misestimation of heritability and prediction accuracy of male-pattern baldness’ Auteurs: Nicola Pirastu, Peter K. Joshi, Paul S. de Vries, Marilyn C. Cornelis, NaNa Keum, Nora Franceschini, Marco Colombo, Edward L. Giovannucci, Athina Spiliopoulou, Lude Franke, Kari E. North, Peter Kraft, Alanna C. Morrison, Tõnu Esko, James F. Wilson Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-018-04808-2 Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions Auteurs: Sulev Reisberg, Kristi Krebs, Maarja Lepamets, Mart Kals, Reedik Mägi, Kristjan Metsalu, Volker M. Lauschke, Jaak Vilo, Lili Milani Publié dans: Genetics in Medicine, Numéro Published Online: 16 October 2018, 2018, Page(s) 1-10, ISSN 1098-3600 Éditeur: Lippincott Williams & Wilkins Ltd. DOI: 10.1038/s41436-018-0337-5 Age at first birth in women is genetically associated with increased risk of schizophrenia Auteurs: Guiyan Ni, Jacob Gratten, Naomi R. Wray, Sang Hong Lee Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/s41598-018-28160-z Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood Auteurs: Guiyan Ni, Gerhard Moser, Naomi R. Wray, S. Hong Lee, Stephan Ripke, Benjamin M. Neale, Aiden Corvin, James T.R. Walters, Kai-How Farh, Peter A. Holmans, Phil Lee, Brendan Bulik-Sullivan, David A. Collier, Hailiang Huang, Tune H. Pers, Ingrid Agartz, Esben Agerbo, Margot Albus, Madeline Alexander, Farooq Amin, Silviu A. Bacanu, Martin Begemann, Richard A. Belliveau, Judit Bene, Sarah E. Bergen, El Publié dans: The American Journal of Human Genetics, Numéro 102/6, 2018, Page(s) 1185-1194, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2018.03.021 Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults Auteurs: Priyanka Parmar, Estelle Lowry, Giovanni Cugliari, Matthew Suderman, Rory Wilson, Ville Karhunen, Toby Andrew, Petri Wiklund, Matthias Wielscher, Simonetta Guarrera, Alexander Teumer, Benjamin Lehne, Lili Milani, Niek de Klein, Pashupati P. Mishra, Phillip E. Melton, Pooja R. Mandaviya, Silva Kasela, Jana Nano, Weihua Zhang, Yan Zhang, Andre G. Uitterlinden, Annette Peters, Ben Schöttker, Christi Publié dans: EBioMedicine, Numéro 38, 2018, Page(s) 206-216, ISSN 2352-3964 Éditeur: Elsevier BV DOI: 10.1016/j.ebiom.2018.10.066 Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps Auteurs: Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, N. William Rayner, Anthony J. Payne, Valgerdur Steinthorsdottir, Robert A. Scott, Niels Grarup, James P. Cook, Ellen M. Schmidt, Matthias Wuttke, Chloé Sarnowski, Reedik Mägi, Jana Nano, Christian Gieger, Stella Trompet, Cécile Lecoeur, Michael H. Preuss, Bram Peter Prins, Xiuqing Guo, Lawrence F. Bielak, Jenni Publié dans: Nature Genetics, Numéro 50/11, 2018, Page(s) 1505-1513, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/s41588-018-0241-6 Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood Auteurs: Ting Qi, Yang Wu, Jian Zeng, Futao Zhang, Angli Xue, Longda Jiang, Zhihong Zhu, Kathryn Kemper, Loic Yengo, Zhili Zheng, Riccardo E. Marioni, Grant W. Montgomery, Ian J. Deary, Naomi R. Wray, Peter M. Visscher, Allan F. McRae, Jian Yang Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-018-04558-1 NIPTmer: rapid k-mer-based software package for detection of fetal aneuploidies Auteurs: Martin Sauk, Olga Žilina, Ants Kurg, Eva-Liina Ustav, Maire Peters, Priit Paluoja, Anne Mari Roost, Hindrek Teder, Priit Palta, Nathalie Brison, Joris R. Vermeesch, Kaarel Krjutškov, Andres Salumets, Lauris Kaplinski Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/s41598-018-23589-8 Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies Auteurs: Sven J. van der Lee, Charlotte E. Teunissen, René Pool, Martin J. Shipley, Alexander Teumer, Vincent Chouraki, Debora Melo van Lent, Juho Tynkkynen, Krista Fischer, Jussi Hernesniemi, Toomas Haller, Archana Singh-Manoux, Aswin Verhoeven, Gonneke Willemsen, Francisca A. de Leeuw, Holger Wagner, Jenny van Dongen, Johannes Hertel, Kathrin Budde, Ko Willems van Dijk, Leonie Weinhold, M. Arfan Ikram, Publié dans: Alzheimer's & Dementia, Numéro 14/6, 2018, Page(s) 707-722, ISSN 1552-5260 Éditeur: Elsevier BV DOI: 10.1016/j.jalz.2017.11.012 Molecular genetic overlap between migraine and major depressive disorder Auteurs: Yuanhao Yang, Huiying Zhao, Dorret I Boomsma, Lannie Ligthart, Andrea C. Belin, George Davey Smith, Tonu Esko, Tobias M. Freilinger, Thomas Folkmann Hansen, M. Arfan Ikram, Mikko Kallela, Christian Kubisch, Christofidou Paraskevi, David P. Strachan, Maija Wessman, Arn M. J. M. van den Maagdenberg, Gisela M. Terwindt, Dale R. Nyholt Publié dans: European Journal of Human Genetics, Numéro 26/8, 2018, Page(s) 1202-1216, ISSN 1018-4813 Éditeur: Natue Publishing Group DOI: 10.1038/s41431-018-0150-2 Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk Auteurs: Yitian Zhou, Reedik Mägi, Lili Milani, Volker M. Lauschke Publié dans: Journal of Lipid Research, Numéro 59/10, 2018, Page(s) 1987-2000, ISSN 0022-2275 Éditeur: Lipid Research, Inc. DOI: 10.1194/jlr.p086710 Hidden heritability due to heterogeneity across seven populations Auteurs: Felix C. Tropf, S. Hong Lee, Renske M. Verweij, Gert Stulp, Peter J. van der Most, Ronald de Vlaming, Andrew Bakshi, Daniel A. Briley, Charles Rahal, Robert Hellpap, Anastasia N. Iliadou, Tõnu Esko, Andres Metspalu, Sarah E. Medland, Nicholas G. Martin, Nicola Barban, Harold Snieder, Matthew R. Robinson, Melinda C. Mills Publié dans: Nature Human Behaviour, Numéro 1/10, 2017, Page(s) 757-765, ISSN 2397-3374 Éditeur: PMC DOI: 10.1038/s41562-017-0195-1 Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes Auteurs: Angli Xue, Yang Wu, Zhihong Zhu, Futao Zhang, Kathryn E. Kemper, Zhili Zheng, Loic Yengo, Luke R. Lloyd-Jones, Julia Sidorenko, Yeda Wu, Allan F. McRae, Peter M. Visscher, Jian Zeng, Jian Yang Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-018-04951-w Signatures of negative selection in the genetic architecture of human complex traits Auteurs: Jian Zeng, Ronald de Vlaming, Yang Wu, Matthew R. Robinson, Luke R. Lloyd-Jones, Loic Yengo, Chloe X. Yap, Angli Xue, Julia Sidorenko, Allan F. McRae, Joseph E. Powell, Grant W. Montgomery, Andres Metspalu, Tonu Esko, Greg Gibson, Naomi R. Wray, Peter M. Visscher, Jian Yang Publié dans: Nature Genetics, Numéro 50/5, 2018, Page(s) 746-753, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/s41588-018-0101-4 IgG glycosylation and DNA methylation are interconnected with smoking Auteurs: Annika Wahl, Silva Kasela, Elena Carnero-Montoro, Maarten van Iterson, Jerko Štambuk, Sapna Sharma, Erik van den Akker, Lucija Klaric, Elisa Benedetti, Genadij Razdorov, Irena Trbojević-Akmačić, Frano Vučković, Ivo Ugrina, Marian Beekman, Joris Deelen, Diana van Heemst, Bastiaan T. Heijmans, B.I.O.S. Consortium, Manfred Wuhrer, Rosina Plomp, Toma Keser, Mirna Šimurina, Tamara Pavić, Ivan Publié dans: Biochimica et Biophysica Acta (BBA) - General Subjects, Numéro 1862/3, 2018, Page(s) 637-648, ISSN 0304-4165 Éditeur: Elsevier BV DOI: 10.1016/j.bbagen.2017.10.012 Noncoding RET variants explain the strong association with Hirschsprung disease in patients without rare coding sequence variant Auteurs: Valtter B. Virtanen, Perttu P. Salo, Jia Cao, Anna Löf-Granström, Lili Milani, Andres Metspalu, Risto J. Rintala, Outi Saarenpää-Heikkilä, Tiina Paunio, Tomas Wester, Agneta Nordenskjöld, Markus Perola, Mikko P. Pakarinen Publié dans: European Journal of Medical Genetics, 2018, ISSN 1769-7212 Éditeur: Elsevier BV DOI: 10.1016/j.ejmg.2018.07.019 Interethnic analyses of blood pressure loci in populations of East Asian and European descent Auteurs: Fumihiko Takeuchi, Masato Akiyama, Nana Matoba, Tomohiro Katsuya, Masahiro Nakatochi, Yasuharu Tabara, Akira Narita, Woei-Yuh Saw, Sanghoon Moon, Cassandra N. Spracklen, Jin-Fang Chai, Young-Jin Kim, Liang Zhang, Chaolong Wang, Huaixing Li, Honglan Li, Jer-Yuarn Wu, Rajkumar Dorajoo, Jovia L. Nierenberg, Ya Xing Wang, Jing He, Derrick A. Bennett, Atsushi Takahashi, Yukihide Momozawa, Makoto Hirata Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-018-07345-0 Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci Auteurs: Tomas Tanskanen, Linda van den Berg, Niko Välimäki, Mervi Aavikko, Eivind Ness-Jensen, Kristian Hveem, Yvonne Wettergren, Elinor Bexe Lindskog, Neeme Tõnisson, Andres Metspalu, Kaisa Silander, Giulia Orlando, Philip J. Law, Sari Tuupanen, Alexandra E. Gylfe, Ulrika A. Hänninen, Tatiana Cajuso, Johanna Kondelin, Antti-Pekka Sarin, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Samuli Ripatti, Publié dans: International Journal of Cancer, Numéro 142/3, 2018, Page(s) 540-546, ISSN 0020-7136 Éditeur: John Wiley & Sons Inc. DOI: 10.1002/ijc.31076 Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity Auteurs: Marina Suhorutshenko, Viktorija Kukushkina, Agne Velthut-Meikas, Signe Altmäe, Maire Peters, Reedik Mägi, Kaarel Krjutškov, Mariann Koel, Francisco M Codoñer, Juan Fco Martinez-Blanch, Felipe Vilella, Carlos Simón, Andres Salumets, Triin Laisk Publié dans: Human Reproduction, Numéro 33/11, 2018, Page(s) 2074-2086, ISSN 0268-1161 Éditeur: Oxford University Press DOI: 10.1093/humrep/dey301 Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants Auteurs: Bin Zhou, James Bentham, Mariachiara Di Cesare, Honor Bixby, Goodarz Danaei, Kaveh Hajifathalian, Cristina Taddei, Rodrigo M Carrillo-Larco, Shirin Djalalinia, Shahab Khatibzadeh, Charles Lugero, Niloofar Peykari, Wan Zhu Zhang, James Bennett, Ver Bilano, Gretchen A Stevens, Melanie J Cowan, Leanne M Riley, Zhengming Chen, Ian R Hambleton, Rod T Jackson, Andre Pascal Kengne, Young-Ho Khang, Avula Publié dans: International Journal of Epidemiology, Numéro 47/3, 2018, Page(s) 872-883i, ISSN 0300-5771 Éditeur: Oxford University Press DOI: 10.1093/ije/dyy016 Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations Auteurs: Kristiina Tambets, Bayazit Yunusbayev, Georgi Hudjashov, Anne-Mai Ilumäe, Siiri Rootsi, Terhi Honkola, Outi Vesakoski, Quentin Atkinson, Pontus Skoglund, Alena Kushniarevich, Sergey Litvinov, Maere Reidla, Ene Metspalu, Lehti Saag, Timo Rantanen, Monika Karmin, Jüri Parik, Sergey I. Zhadanov, Marina Gubina, Larisa D. Damba, Marina Bermisheva, Tuuli Reisberg, Khadizhat Dibirova, Irina Evseeva, Ma Publié dans: Genome Biology, Numéro 19/1, 2018, Page(s) 1-20, ISSN 1474-760X Éditeur: BMC DOI: 10.1186/s13059-018-1522-1 Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error Auteurs: Milly S. Tedja, Robert Wojciechowski, Pirro G. Hysi, Nicholas Eriksson, Nicholas A. Furlotte, Virginie J. M. Verhoeven, Adriana I. Iglesias, Magda A. Meester-Smoor, Stuart W. Tompson, Qiao Fan, Anthony P. Khawaja, Ching-Yu Cheng, René Höhn, Kenji Yamashiro, Adam Wenocur, Clare Grazal, Toomas Haller, Andres Metspalu, Juho Wedenoja, Jost B. Jonas, Ya Xing Wang, Jing Xie, Paul Mitchell, Paul J. Fos Publié dans: Nature Genetics, Numéro 50/6, 2018, Page(s) 834-848, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/s41588-018-0127-7 Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study Auteurs: Katerina Trajanoska, John A Morris, Ling Oei, Hou-Feng Zheng, David M Evans, Douglas P Kiel, Claes Ohlsson, J Brent Richards, Fernando Rivadeneira Publié dans: BMJ, Numéro BMJ 2018; 362, 2018, Page(s) k3225, ISSN 0959-8138 Éditeur: British Medical Association DOI: 10.1136/bmj.k3225 Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity Auteurs: Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff, Xiuqing Guo, Audrey E. Hendricks, Tugce Karaderi, Adelheid Lempradl, Adam E. Locke, Anubha Mahajan, Eirini Marouli, Suthesh Sivapalaratnam, Kristin L. Young, Tamuno Alfred, Mary F. Feitosa, Nicholas G. D. Masca, Alisa K. Manning, Publié dans: Nature Genetics, Numéro 50/1, 2018, Page(s) 26-41, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/s41588-017-0011-x Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression Auteurs: Naomi R. Wray, Stephan Ripke, Manuel Mattheisen, Maciej Trzaskowski, Enda M. Byrne, Abdel Abdellaoui, Mark J. Adams, Esben Agerbo, Tracy M. Air, Till M. F. Andlauer, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan F. T. Beekman, Tim B. Bigdeli, Elisabeth B. Binder, Douglas R. H. Blackwood, Julien Bryois, Henriette N. Buttenschøn, Jonas Bybjerg-Grauholm, Na Cai, Enrique Castelao, Jane Hvarregaar Publié dans: Nature Genetics, Numéro 50/5, 2018, Page(s) 668-681, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/s41588-018-0090-3 TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting Auteurs: Hindrek Teder, Mariann Koel, Priit Paluoja, Tatjana Jatsenko, Kadri Rekker, Triin Laisk-Podar, Viktorija Kukuškina, Agne Velthut-Meikas, Olga Fjodorova, Maire Peters, Juha Kere, Andres Salumets, Priit Palta, Kaarel Krjutškov Publié dans: npj Genomic Medicine, Numéro 3/1, 2018, ISSN 2056-7944 Éditeur: Springer Nature Publishing AG DOI: 10.1038/s41525-018-0072-5 A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure Auteurs: Yun J. Sung, Thomas W. Winkler, Lisa de las Fuentes, Amy R. Bentley, Michael R. Brown, Aldi T. Kraja, Karen Schwander, Ioanna Ntalla, Xiuqing Guo, Nora Franceschini, Yingchang Lu, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K. Musani, Changwei Li, Mary F. Feitosa, Tuomas O. Kilpeläinen, Melissa A. Richard, Raymond Noordam, Stella Aslibekyan, Hugues Aschard, Traci M. Bart Publié dans: The American Journal of Human Genetics, Numéro 102/3, 2018, Page(s) 375-400, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2018.01.015 Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits Auteurs: Nathalie Chami, Ming-Huei Chen, Andrew J. Slater, John D. Eicher, Evangelos Evangelou, Salman M. Tajuddin, Latisha Love-Gregory, Tim Kacprowski, Ursula M. Schick, Akihiro Nomura, Ayush Giri, Samuel Lessard, Jennifer A. Brody, Claudia Schurmann, Nathan Pankratz, Lisa R. Yanek, Ani Manichaikul, Raha Pazoki, Evelin Mihailov, W. David Hill, Laura M. Raffield, Amber Burt, Traci M. Bartz, Diane Publié dans: The American Journal of Human Genetics, Numéro 99/1, 2016, Page(s) 8-21, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2016.05.007 Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals Auteurs: John D. Eicher, Nathalie Chami, Tim Kacprowski, Akihiro Nomura, Ming-Huei Chen, Lisa R. Yanek, Salman M. Tajuddin, Ursula M. Schick, Andrew J. Slater, Nathan Pankratz, Linda Polfus, Claudia Schurmann, Ayush Giri, Jennifer A. Brody, Leslie A. Lange, Ani Manichaikul, W. David Hill, Raha Pazoki, Paul Elliot, Evangelos Evangelou, Ioanna Tzoulaki, He Gao, Anne-Claire Vergnaud, Rasika A. Mathia Publié dans: The American Journal of Human Genetics, Numéro 99/1, 2016, Page(s) 40-55, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2016.05.005 Ultra-rare disruptive and damaging mutations influence educational attainment in the general population Auteurs: Andrea Ganna, Giulio Genovese, Daniel P Howrigan, Andrea Byrnes, Mitja I Kurki, Seyedeh M Zekavat, Christopher W Whelan, Mart Kals, Michel G Nivard, Alex Bloemendal, Jonathan M Bloom, Jacqueline I Goldstein, Timothy Poterba, Cotton Seed, Robert E Handsaker, Pradeep Natarajan, Reedik Mägi, Diane Gage, Elise B Robinson, Andres Metspalu, Veikko Salomaa, Jaana Suvisaari, Shaun M Purcell, Pamela Sklar Publié dans: Nature Neuroscience, Numéro 19/12, 2016, Page(s) 1563-1565, ISSN 1097-6256 Éditeur: Nature Publishing Group DOI: 10.1038/nn.4404 Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores Auteurs: Kristi Läll, Reedik Mägi, Andrew Morris, Andres Metspalu, Krista Fischer Publié dans: Genetics in Medicine, Numéro 19/3, 2016, Page(s) 322-329, ISSN 1098-3600 Éditeur: Lippincott Williams & Wilkins Ltd. DOI: 10.1038/gim.2016.103 Whole-exome sequencing identifies a potential TTN mutation in a multiplex family with inguinal hernia Auteurs: E. Mihailov, T. Nikopensius, A. Reigo, C. Nikkolo, M. Kals, K. Aruaas, L. Milani, H. Seepter, A. Metspalu Publié dans: Hernia, Numéro 21/1, 2017, Page(s) 95-100, ISSN 1265-4906 Éditeur: Springer Verlag DOI: 10.1007/s10029-016-1491-9 Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension Auteurs: Praveen Surendran, Fotios Drenos, Robin Young, Helen Warren, James P Cook, Alisa K Manning, Niels Grarup, Xueling Sim, Daniel R Barnes, Kate Witkowska, James R Staley, Vinicius Tragante, Taru Tukiainen, Hanieh Yaghootkar, Nicholas Masca, Daniel F Freitag, Teresa Ferreira, Olga Giannakopoulou, Andrew Tinker, Magdalena Harakalova, Evelin Mihailov, Chunyu Liu, Aldi T Kraja, Sune Fallgaard Nielsen, As Publié dans: Nature Genetics, Numéro 48/10, 2016, Page(s) 1151-1161, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3654 Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases Auteurs: Salman M. Tajuddin, Ursula M. Schick, John D. Eicher, Nathalie Chami, Ayush Giri, Jennifer A. Brody, W. David Hill, Tim Kacprowski, Jin Li, Leo-Pekka Lyytikäinen, Ani Manichaikul, Evelin Mihailov, Michelle L. O’Donoghue, Nathan Pankratz, Raha Pazoki, Linda M. Polfus, Albert Vernon Smith, Claudia Schurmann, Caterina Vacchi-Suzzi, Dawn M. Waterworth, Evangelos Evangelou, Lisa R. Yanek, Publié dans: The American Journal of Human Genetics, Numéro 99/1, 2016, Page(s) 22-39, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2016.05.003 Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms Auteurs: Michael H. Guo, Satish K. Nandakumar, Jacob C. Ulirsch, Seyedeh M. Zekavat, Jason D. Buenrostro, Pradeep Natarajan, Rany M. Salem, Roberto Chiarle, Mario Mitt, Mart Kals, Kalle Pärn, Krista Fischer, Lili Milani, Reedik Mägi, Priit Palta, Stacey B. Gabriel, Andres Metspalu, Eric S. Lander, Sekar Kathiresan, Joel N. Hirschhorn, Tõnu Esko, Vijay G. Sankaran Publié dans: Proceedings of the National Academy of Sciences, Numéro 114/3, 2017, Page(s) E327-E336, ISSN 0027-8424 Éditeur: National Academy of Sciences DOI: 10.1073/pnas.1619052114 MixFit: Methodology for Computing Ancestry-Related Genetic Scores at the Individual Level and Its Application to the Estonian and Finnish Population Studies Auteurs: Toomas Haller, Liis Leitsalu, Krista Fischer, Marja-Liisa Nuotio, Tõnu Esko, Dorothea Irene Boomsma, Kirsten Ohm Kyvik, Tim D. Spector, Markus Perola, Andres Metspalu Publié dans: PLOS ONE, Numéro 12/1, 2017, Page(s) e0170325, ISSN 1932-6203 Éditeur: Public Library of Science DOI: 10.1371/journal.pone.0170325 Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells Auteurs: Silva Kasela, Kai Kisand, Liina Tserel, Epp Kaleviste, Anu Remm, Krista Fischer, Tõnu Esko, Harm-Jan Westra, Benjamin P. Fairfax, Seiko Makino, Julian C. Knight, Lude Franke, Andres Metspalu, Pärt Peterson, Lili Milani Publié dans: PLOS Genetics, Numéro 13/3, 2017, Page(s) e1006643, ISSN 1553-7404 Éditeur: PLOS DOI: 10.1371/journal.pgen.1006643 Genome-wide analysis identifies 12 loci influencing human reproductive behavior Auteurs: Nicola Barban, Rick Jansen, Ronald de Vlaming, Ahmad Vaez, Jornt J Mandemakers, Felix C Tropf, Xia Shen, James F Wilson, Daniel I Chasman, Ilja M Nolte, Vinicius Tragante, Sander W van der Laan, John R B Perry, Augustine Kong, Tarunveer S Ahluwalia, Eva Albrecht, Laura Yerges-Armstrong, Gil Atzmon, Kirsi Auro, Kristin Ayers, Andrew Bakshi, Danny Ben-Avraham, Klaus Berger, Aviv Bergman, Lars Bertra Publié dans: Nature Genetics, Numéro 48/12, 2016, Page(s) 1462-1472, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3698 Genetic variants in RBFOX3 are associated with sleep latency Auteurs: Najaf Amin, Karla V Allebrandt, Ashley van der Spek, Bertram Müller-Myhsok, Karin Hek, Maris Teder-Laving, Caroline Hayward, Tõnu Esko, Josine G van Mill, Hamdi Mbarek, Nathaniel F Watson, Scott A Melville, Fabiola M Del Greco, Enda M Byrne, Edwin Oole, Ivana Kolcic, Ting-hsu Chen, Daniel S Evans, Josef Coresh, Nicole Vogelzangs, Juha Karjalainen, Gonneke Willemsen, Sina A Gharib, Lina Zgaga, Ev Publié dans: European Journal of Human Genetics, Numéro 24/10, 2016, Page(s) 1488-1495, ISSN 1018-4813 Éditeur: Natue Publishing Group DOI: 10.1038/ejhg.2016.31 Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness Auteurs: Tim B. Bigdeli, Stephan Ripke, Silviu-Alin Bacanu, Sang Hong Lee, Naomi R. Wray, Pablo V. Gejman, Marcella Rietschel, Sven Cichon, David St Clair, Aiden Corvin, George Kirov, Andrew McQuillin, Hugh Gurling, Dan Rujescu, Ole A. Andreassen, Thomas Werge, Douglas H. R. Blackwood, Carlos N. Pato, Michele T. Pato, Anil K. Malhotra, Michael C. O'Donovan, Kenneth S. Kendler, Ayman H. Fanous Publié dans: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Numéro 171/2, 2016, Page(s) 276-289, ISSN 1552-4841 Éditeur: Wiley-Liss Inc DOI: 10.1002/ajmg.b.32402 Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence Auteurs: Alejandro Cáceres, Tõnu Esko, Irene Pappa, Armand Gutiérrez, Maria-Jose Lopez-Espinosa, Sabrina Llop, Mariona Bustamante, Henning Tiemeier, Andres Metspalu, Peter K. Joshi, James F. Wilsonx, Judith Reina-Castillón, Jean Shin, Zdenka Pausova, Tomáš Paus, Jordi Sunyer, Luis A. Pérez-Jurado, Juan R. González Publié dans: PLOS ONE, Numéro 11/6, 2016, Page(s) e0157739, ISSN 1932-6203 Éditeur: Public Library of Science DOI: 10.1371/journal.pone.0157739 Defining the Effect of the 16p11.2 Duplication on Cognition, Behavior, and Medical Comorbidities Auteurs: Debra D’Angelo, Sébastien Lebon, Qixuan Chen, Sandra Martin-Brevet, LeeAnne Green Snyder, Loyse Hippolyte, Ellen Hanson, Anne M. Maillard, W. Andrew Faucett, Aurélien Macé, Aurélie Pain, Raphael Bernier, Samuel J. R. A. Chawner, Albert David, Joris Andrieux, Elizabeth Aylward, Genevieve Baujat, Ines Caldeira, Philippe Conus, Carrina Ferrari, Francesca Forzano, Marion Gérard, Robin P. Goin-K Publié dans: JAMA Psychiatry, Numéro 73/1, 2016, Page(s) 20, ISSN 2168-622X Éditeur: American Medical Association DOI: 10.1001/jamapsychiatry.2015.2123 Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants Auteurs: NCD Risk Factor Collaboration (NCD-RisC) Publié dans: The Lancet, Numéro 387/10026, 2016, Page(s) 1377-1396, ISSN 0140-6736 Éditeur: The Lancet Publishing Group DOI: 10.1016/S0140-6736(16)30054-X Genome-wide association study of serum coenzyme Q 10 levels identifies susceptibility loci linked to neuronal diseases Auteurs: Frauke Degenhardt, Petra Niklowitz, Silke Szymczak, Gunnar Jacobs, Wolfgang Lieb, Thomas Menke, Matthias Laudes, Tõnu Esko, Stephan Weidinger, Andre Franke, Frank Döring, Simone Onur Publié dans: Human Molecular Genetics, 2016, Page(s) ddw134, ISSN 0964-6906 Éditeur: Oxford University Press DOI: 10.1093/hmg/ddw134 The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals Auteurs: Georg B Ehret, Teresa Ferreira, Daniel I Chasman, Anne U Jackson, Ellen M Schmidt, Toby Johnson, Gudmar Thorleifsson, Jian'an Luan, Louise A Donnelly, Stavroula Kanoni, Ann-Kristin Petersen, Vasyl Pihur, Rona J Strawbridge, Dmitry Shungin, Maria F Hughes, Osorio Meirelles, Marika Kaakinen, Nabila Bouatia-Naji, Kati Kristiansson, Sonia Shah, Marcus E Kleber, Xiuqing Guo, Leo-Pekka Lyytikäinen, Cri Publié dans: Nature Genetics, Numéro 48/10, 2016, Page(s) 1171-1184, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3667 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci Auteurs: David Ellinghaus, Luke Jostins, Sarah L Spain, Adrian Cortes, Jörn Bethune, Buhm Han, Yu Rang Park, Soumya Raychaudhuri, Jennie G Pouget, Matthias Hübenthal, Trine Folseraas, Yunpeng Wang, Tonu Esko, Andres Metspalu, Harm-Jan Westra, Lude Franke, Tune H Pers, Rinse K Weersma, Valerie Collij, Mauro D'Amato, Jonas Halfvarson, Anders Boeck Jensen, Wolfgang Lieb, Franziska Degenhardt, Andreas J Fors Publié dans: Nature Genetics, Numéro 48/5, 2016, Page(s) 510-518, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3528 Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium Auteurs: Qiao Fan, Xiaobo Guo, J. Willem L. Tideman, Katie M. Williams, Seyhan Yazar, S. Mohsen Hosseini, Laura D. Howe, Beaté St Pourcain, David M. Evans, Nicholas J. Timpson, George McMahon, Pirro G. Hysi, Eva Krapohl, Ya Xing Wang, Jost B. Jonas, Paul Nigel Baird, Jie Jin Wang, Ching-Yu Cheng, Yik-Ying Teo, Tien-Yin Wong, Xiaohu Ding, Robert Wojciechowski, Terri L. Young, Olavi Pärssinen, Konrad Oexle Publié dans: Scientific Reports, Numéro 6/1, 2016, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/srep25853 Cardiovascular Risk Factors and Ischemic Heart DiseaseCLINICAL PERSPECTIVE Auteurs: Roberto Elosua, Carla Lluís-Ganella, Isaac Subirana, Aki Havulinna, Kristi Läll, Gavin Lucas, Sergi Sayols-Baixeras, Arto Pietilä, Maris Alver, Antonio Cabrera de León, Mariano Sentí, David Siscovick, Olle Mellander, Krista Fischer, Veikko Salomaa, Jaume Marrugat Publié dans: Circulation: Cardiovascular Genetics, Numéro 9/3, 2016, Page(s) 279-286, ISSN 1942-3268 Éditeur: Lippincott Williams & Wilkins Ltd. DOI: 10.1161/CIRCGENETICS.115.001255 Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine Auteurs: Padhraig Gormley, Verneri Anttila, Bendik S Winsvold, Priit Palta, Tonu Esko, Tune H Pers, Kai-How Farh, Ester Cuenca-Leon, Mikko Muona, Nicholas A Furlotte, Tobias Kurth, Andres Ingason, George McMahon, Lannie Ligthart, Gisela M Terwindt, Mikko Kallela, Tobias M Freilinger, Caroline Ran, Scott G Gordon, Anine H Stam, Stacy Steinberg, Guntram Borck, Markku Koiranen, Lydia Quaye, Hieab H H Adams, T Publié dans: Nature Genetics, Numéro 48/8, 2016, Page(s) 856-866, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3598 Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci Auteurs: Kyle J Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo, Reedik Mägi, Michael E Reschen, Anubha Mahajan, Adam Locke, N William Rayner, Neil Robertson, Robert A Scott, Inga Prokopenko, Laura J Scott, Todd Green, Thomas Sparso, Dorothee Thuillier, Loic Yengo, Harald Grallert, Simone Wahl, Mattias Frånberg, Rona J Strawbridge, Hans Kestler, Himanshu Chheda, Lewin Eisele, Stefan Gustafsson, Valgerd Publié dans: Nature Genetics, Numéro 47/12, 2015, Page(s) 1415-1425, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3437 The Number of Genomic Copies at the 16p11.2 Locus Modulates Language, Verbal Memory, and Inhibition Auteurs: Loyse Hippolyte, Anne M. Maillard, Borja Rodriguez-Herreros, Aurélie Pain, Sandra Martin-Brevet, Carina Ferrari, Philippe Conus, Aurélien Macé, Nouchine Hadjikhani, Andres Metspalu, Anu Reigo, Anneli Kolk, Katrin Männik, Mandy Barker, Bertrand Isidor, Cédric Le Caignec, Cyril Mignot, Laurence Schneider, Laurent Mottron, Boris Keren, Albert David, Martine Doco-Fenzy, Marion Gérard, Raphael Be Publié dans: Biological Psychiatry, Numéro 80/2, 2016, Page(s) 129-139, ISSN 0006-3223 Éditeur: Elsevier BV DOI: 10.1016/j.biopsych.2015.10.021 Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept Auteurs: Barbara Franke, Jason L Stein, Stephan Ripke, Verneri Anttila, Derrek P Hibar, Kimm J E van Hulzen, Alejandro Arias-Vasquez, Jordan W Smoller, Thomas E Nichols, Michael C Neale, Andrew M McIntosh, Phil Lee, Francis J McMahon, Andreas Meyer-Lindenberg, Manuel Mattheisen, Ole A Andreassen, Oliver Gruber, Perminder S Sachdev, Roberto Roiz-Santiañez, Andrew J Saykin, Stefan Ehrlich, Karen A Mather, J Publié dans: Nature Neuroscience, Numéro 19/3, 2016, Page(s) 420-431, ISSN 1097-6256 Éditeur: Nature Publishing Group DOI: 10.1038/nn.4228 Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells Auteurs: Felix C. Giani, Claudia Fiorini, Aoi Wakabayashi, Leif S. Ludwig, Rany M. Salem, Chintan D. Jobaliya, Stephanie N. Regan, Jacob C. Ulirsch, Ge Liang, Orna Steinberg-Shemer, Michael H. Guo, Tõnu Esko, Wei Tong, Carlo Brugnara, Joel N. Hirschhorn, Mitchell J. Weiss, Leonard I. Zon, Stella T. Chou, Deborah L. French, Kiran Musunuru, Vijay G. Sankaran Publié dans: Cell Stem Cell, Numéro 18/1, 2016, Page(s) 73-78, ISSN 1934-5909 Éditeur: Cell Press DOI: 10.1016/j.stem.2015.09.015 Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error Auteurs: Qiao Fan, Virginie J. M. Verhoeven, Robert Wojciechowski, Veluchamy A. Barathi, Pirro G. Hysi, Jeremy A. Guggenheim, René Höhn, Veronique Vitart, Anthony P. Khawaja, Kenji Yamashiro, S Mohsen Hosseini, Terho Lehtimäki, Yi Lu, Toomas Haller, Jing Xie, Cécile Delcourt, Mario Pirastu, Juho Wedenoja, Puya Gharahkhani, Cristina Venturini, Masahiro Miyake, Alex W. Hewitt, Xiaobo Guo, Johanna Mazur, Publié dans: Nature Communications, Numéro 7, 2016, Page(s) 11008, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms11008 Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index Auteurs: A Hinney, M Kesselmeier, S Jall, A-L Volckmar, M Föcker, J Antel, Vesna Boraska Perica, Christopher S Franklin, James A B Floyd, Laura M Thornton, Laura M Huckins, Lorraine Southam, N William Rayner, Ioanna Tachmazidou, Kelly L Klump, Janet Treasure, Cathryn M Lewis, Ulrike Schmidt, Federica Tozzi, Kirsty iezebrink, Johannes Hebebrand, Philip Gorwood, Roger A H Adan, Martien J H Kas, Angela Favar Publié dans: Molecular Psychiatry, Numéro 22/2, 2016, Page(s) 192-201, ISSN 1359-4184 Éditeur: Nature Publishing Group DOI: 10.1038/mp.2016.71 The genetic architecture of type 2 diabetes Auteurs: Christian Fuchsberger, Jason Flannick, Tanya M. Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J. Gaulton, Clement Ma, Pierre Fontanillas, Loukas Moutsianas, Davis J. McCarthy, Manuel A. Rivas, John R. B. Perry, Xueling Sim, Thomas W. Blackwell, Neil R. Robertson, N. William Rayner, Pablo Cingolani, Adam E. Locke, Juan Fernandez Tajes, Heather M. Highland, Josee Dupuis, Peter S. Chines, Cecilia Publié dans: Nature, Numéro 536/7614, 2016, Page(s) 41-47, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature18642 A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking Auteurs: Tianxiao Huan, Roby Joehanes, Claudia Schurmann, Katharina Schramm, Luke C. Pilling, Marjolein J. Peters, Reedik Mägi, Dawn DeMeo, George T O'Connor, Luigi Ferrucci, Alexander Teumer, Georg Homuth, Reiner Biffar, Uwe Völker, Christian Herder, Melanie Waldenberger, Annette Peters, Sonja Zeilinger, Andres Metspalu, Albert Hofman, André G. Uitterlinden, Dena G. Hernandez, Andrew B. Singleton, Stef Publié dans: Human Molecular Genetics, Numéro 25 (21): 4611-4623., 2016, Page(s) ddw288, ISSN 0964-6906 Éditeur: Oxford University Press DOI: 10.1093/hmg/ddw288 Selective sweep on human amylase genes postdates the split with Neanderthals Auteurs: Charlotte E. Inchley, Cynthia D. A. Larbey, Nzar A. A. Shwan, Luca Pagani, Lauri Saag, Tiago Antão, Guy Jacobs, Georgi Hudjashov, Ene Metspalu, Mario Mitt, Christina A. Eichstaedt, Boris Malyarchuk, Miroslava Derenko, Joseph Wee, Syafiq Abdullah, François-Xavier Ricaut, Maru Mormina, Reedik Mägi, Richard Villems, Mait Metspalu, Martin K. Jones, John A. L. Armour, Toomas Kivisild Publié dans: Scientific Reports, Numéro 6/1, 2016, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/srep37198 Autosomal genetic control of human gene expression does not differ across the sexes Auteurs: Irfahan Kassam, Luke Lloyd-Jones, Alexander Holloway, Kerrin S. Small, Biao Zeng, Andrew Bakshi, Andres Metspalu, Greg Gibson, Tim D. Spector, Tonu Esko, Grant W. Montgomery, Joseph E. Powell, Jian Yang, Peter M. Visscher, Allan F. McRae Publié dans: Genome Biology, Numéro 17/1, 2016, ISSN 1474-760X Éditeur: BioMed Central DOI: 10.1186/s13059-016-1111-0 Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression Auteurs: Maxim Ivanov, Mart Kals, Volker Lauschke, Isabel Barragan, Philip Ewels, Max Käller, Tomas Axelsson, Janne Lehtiö, Lili Milani, Magnus Ingelman-Sundberg Publié dans: Nucleic Acids Research, Numéro 44/14, 2016, Page(s) 6756-6769, ISSN 0305-1048 Éditeur: Oxford University Press DOI: 10.1093/nar/gkw316 Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA Auteurs: Johannes Kettunen, Ayşe Demirkan, Peter Würtz, Harmen H.M. Draisma, Toomas Haller, Rajesh Rawal, Anika Vaarhorst, Antti J. Kangas, Leo-Pekka Lyytikäinen, Matti Pirinen, René Pool, Antti-Pekka Sarin, Pasi Soininen, Taru Tukiainen, Qin Wang, Mika Tiainen, Tuulia Tynkkynen, Najaf Amin, Tanja Zeller, Marian Beekman, Joris Deelen, Ko Willems van Dijk, Tõnu Esko, Jouke-Jan Hottenga, Elisabeth M van Publié dans: Nature Communications, Numéro 7, 2016, Page(s) 11122, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms11122 Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan Auteurs: Peter K. Joshi, Krista Fischer, Katharina E. Schraut, Harry Campbell, Tõnu Esko, James F. Wilson Publié dans: Nature Communications, Numéro 7, 2016, Page(s) 11174, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms11174 Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci Auteurs: Samuel E. Jones, Jessica Tyrrell, Andrew R. Wood, Robin N. Beaumont, Katherine S. Ruth, Marcus A. Tuke, Hanieh Yaghootkar, Youna Hu, Maris Teder-Laving, Caroline Hayward, Till Roenneberg, James F. Wilson, Fabiola Del Greco, Andrew A. Hicks, Chol Shin, Chang-Ho Yun, Seung Ku Lee, Andres Metspalu, Enda M. Byrne, Philip R. Gehrman, Henning Tiemeier, Karla V. Allebrandt, Rachel M. Freathy, Anna Murray Publié dans: PLOS Genetics, Numéro 12/8, 2016, Page(s) e1006125, ISSN 1553-7404 Éditeur: PLOS DOI: 10.1371/journal.pgen.1006125 SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function Auteurs: Man Li, Yong Li, Olivia Weeks, Vladan Mijatovic, Alexander Teumer, Jennifer E. Huffman, Gerard Tromp, Christian Fuchsberger, Mathias Gorski, Leo-Pekka Lyytikäinen, Teresa Nutile, Sanaz Sedaghat, Rossella Sorice, Adrienne Tin, Qiong Yang, Tarunveer S. Ahluwalia, Dan E. Arking, Nathan A. Bihlmeyer, Carsten A. Böger, Robert J. Carroll, Daniel I. Chasman, Marilyn C. Cornelis, Abbas Dehghan, Jessica Publié dans: Journal of the American Society of Nephrology, Numéro 28/3, 2017, Page(s) 981-994, ISSN 1046-6673 Éditeur: Lippincott Williams & Wilkins Ltd. DOI: 10.1681/ASN.2016020131 Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis Auteurs: Po-Ru Loh, Gaurav Bhatia, Alexander Gusev, Hilary K Finucane, Brendan K Bulik-Sullivan, Samuela J Pollack, Teresa R de Candia, Sang Hong Lee, Naomi R Wray, Kenneth S Kendler, Michael C O'Donovan, Benjamin M Neale, Nick Patterson, Alkes L Price Publié dans: Nature Genetics, Numéro 47/12, 2015, Page(s) 1385-1392, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3431 No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis Auteurs: Christina Loley, Maris Alver, Themistocles L. Assimes, Andrew Bjonnes, Anuj Goel, Stefan Gustafsson, Jussi Hernesniemi, Jemma C. Hopewell, Stavroula Kanoni, Marcus E. Kleber, King Wai Lau, Yingchang Lu, Leo-Pekka Lyytikäinen, Christopher P. Nelson, Majid Nikpay, Liming Qu, Elias Salfati, Markus Scholz, Taru Tukiainen, Christina Willenborg, Hong-Hee Won, Lingyao Zeng, Weihua Zhang, Sonia S. Anand, Publié dans: Scientific Reports, Numéro 6/1, 2016, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/srep35278 Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond Auteurs: Triin Laisk-Podar, Cecilia M. Lindgren, Maire Peters, Juha S. Tapanainen, Cornelis B. Lambalk, Andres Salumets, Reedik Mägi Publié dans: Trends in Endocrinology & Metabolism, Numéro 27/7, 2016, Page(s) 516-528, ISSN 1043-2760 Éditeur: Elsevier BV DOI: 10.1016/j.tem.2016.04.011 Testing the role of predicted gene knockouts in human anthropometric trait variation Auteurs: Samuel Lessard, Alisa K. Manning, Cécile Low-Kam, Paul L. Auer, Ayush Giri, Mariaelisa Graff, Claudia Schurmann, Hanieh Yaghootkar, Jian'an Luan, Tonu Esko, Tugce Karaderi, Erwin P. Bottinger, Yingchang Lu, Chris Carlson, Mark Caulfield, Marie-Pierre Dubé, Rebecca D. Jackson, Charles Kooperberg, Barbara McKnight, Ian Mongrain, Ulrike Peters, Alex P. Reiner, David Rhainds, Nona Sotoodehnia, Joel Publié dans: Human Molecular Genetics, Numéro 25/10, 2016, Page(s) 2082-2092, ISSN 0964-6906 Éditeur: Oxford University Press DOI: 10.1093/hmg/ddw055 Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling Auteurs: Maia Limbach, Mario Saare, Liina Tserel, Kai Kisand, Triin Eglit, Sascha Sauer, Tomas Axelsson, Ann-Christine Syvänen, Andres Metspalu, Lili Milani, Pärt Peterson Publié dans: Journal of Autoimmunity, Numéro 67, 2016, Page(s) 46-56, ISSN 0896-8411 Éditeur: Academic Press DOI: 10.1016/j.jaut.2015.09.006 Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels Auteurs: Tuomas O. Kilpeläinen, Jayne F. Martin Carli, Alicja A. Skowronski, Qi Sun, Jennifer Kriebel, Mary F Feitosa, Åsa K. Hedman, Alexander W. Drong, James E. Hayes, Jinghua Zhao, Tune H. Pers, Ursula Schick, Niels Grarup, Zoltán Kutalik, Stella Trompet, Massimo Mangino, Kati Kristiansson, Marian Beekman, Leo-Pekka Lyytikäinen, Joel Eriksson, Peter Henneman, Jari Lahti, Toshiko Tanaka, Jian’an Lu Publié dans: Nature Communications, Numéro 7, 2016, Page(s) 10494, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms10494 The Role of the Five-factor Personality Traits in General Self-rated Health Auteurs: Liisi Kööts-Ausmees, Monika Schmidt, Tõnu Esko, Andres Metspalu, Jüri Allik, Anu Realo Publié dans: European Journal of Personality, Numéro 30/5, 2016, Page(s) 492-504, ISSN 0890-2070 Éditeur: John Wiley & Sons Inc. DOI: 10.1002/per.2058 Ageing with elegans: a research proposal to map healthspan pathways Auteurs: Walter Luyten, Peter Antal, Bart P. Braeckman, Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, Armand Leroi, Qingfei Liu, Patricia Martorell, Andres Metspalu, Markus Perola, Michael Ristow, Nadine Saul, Liliane Schoofs, Karsten Siems, Liesbet Temmerman, Tina Smets, Alicja Wolk, Suresh I. S. Rattan Publié dans: Biogerontology, Numéro 17/4, 2016, Page(s) 771-782, ISSN 1389-5729 Éditeur: Kluwer Academic Publishers DOI: 10.1007/s10522-016-9644-x New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk Auteurs: Yingchang Lu, Felix R. Day, Stefan Gustafsson, Martin L. Buchkovich, Jianbo Na, Veronique Bataille, Diana L. Cousminer, Zari Dastani, Alexander W. Drong, Tõnu Esko, David M. Evans, Mario Falchi, Mary F. Feitosa, Teresa Ferreira, Åsa K. Hedman, Robin Haring, Pirro G. Hysi, Mark M. Iles, Anne E. Justice, Stavroula Kanoni, Vasiliki Lagou, Rui Li, Xin Li, Adam Locke, Chen Lu, Reedik Mägi, John R. B Publié dans: Nature Communications, Numéro 7, 2016, Page(s) 10495, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms10495 Genome-Wide Meta-Analysis of Sciatica in Finnish Population Auteurs: Susanna Lemmelä, Svetlana Solovieva, Rahman Shiri, Christian Benner, Markku Heliövaara, Johannes Kettunen, Verneri Anttila, Samuli Ripatti, Markus Perola, Ilkka Seppälä, Markus Juonala, Mika Kähönen, Veikko Salomaa, Jorma Viikari, Olli T. Raitakari, Terho Lehtimäki, Aarno Palotie, Eira Viikari-Juntura, Kirsti Husgafvel-Pursiainen Publié dans: PLOS ONE, Numéro 11/10, 2016, Page(s) e0163877, ISSN 1932-6203 Éditeur: Public Library of Science DOI: 10.1371/journal.pone.0163877 16p11.2 Locus modulates response to satiety before the onset of obesity Auteurs: A M Maillard, L Hippolyte, B Rodriguez-Herreros, S J R A Chawner, D Dremmel, Z Agüera, A B Fagundo, A Pain, S Martin-Brevet, A Hilbert, S Kurz, R Etienne, B Draganski, S Jimenez-Murcia, K Männik, A Metspalu, A Reigo, B Isidor, C Le Caignec, A David, C Mignot, B Keren, M B M van den Bree, S Munsch, F Fernandez-Aranda, J S Beckmann, A Reymond, S Jacquemont Publié dans: International Journal of Obesity, Numéro 40/5, 2015, Page(s) 870-876, ISSN 0307-0565 Éditeur: Nature Publishing Group DOI: 10.1038/ijo.2015.247 Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women Auteurs: Divya Mehta, Felix C. Tropf, Jacob Gratten, Andrew Bakshi, Zhihong Zhu, Silviu-Alin Bacanu, Gibran Hemani, Patrik K. E. Magnusson, Nicola Barban, Tõnu Esko, Andres Metspalu, Harold Snieder, Bryan J. Mowry, Kenneth S. Kendler, Jian Yang, Peter M. Visscher, John J. McGrath, Melinda C. Mills, Naomi R. Wray, S. Hong Lee, Ole A. Andreassen, Elvira Bramon, Richard Bruggeman, Joseph D. Buxbaum, Murray J Publié dans: JAMA Psychiatry, Numéro 73/5, 2016, Page(s) 497, ISSN 2168-622X Éditeur: American Medical Association DOI: 10.1001/jamapsychiatry.2016.0129 Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses Auteurs: Aysu Okbay, Bart M L Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G Nivard, Mark Alan Fontana, S Fleur W Meddens, Richard Karlsson Linnér, Cornelius A Rietveld, Jaime Derringer, Jacob Gratten, James J Lee, Jimmy Z Liu, Ronald de Vlaming, Tarunveer S Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C Frazier-Wood, Nicholas A Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R G Publié dans: Nature Genetics, Numéro 48/6, 2016, Page(s) 624-633, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3552 Genome-wide association study identifies 74 loci associated with educational attainment Auteurs: Aysu Okbay, Jonathan P. Beauchamp, Mark Alan Fontana, James J. Lee, Tune H. Pers, Cornelius A. Rietveld, Patrick Turley, Guo-Bo Chen, Valur Emilsson, S. Fleur W. Meddens, Sven Oskarsson, Joseph K. Pickrell, Kevin Thom, Pascal Timshel, Ronald de Vlaming, Abdel Abdellaoui, Tarunveer S. Ahluwalia, Jonas Bacelis, Clemens Baumbach, Gyda Bjornsdottir, Johannes H. Brandsma, Maria Pina Concas, Jaime Derri Publié dans: Nature, Numéro 533/7604, 2016, Page(s) 539-542, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature17671 Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease Auteurs: Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kanoni S, Kruppa J, Mahajan A, Scott RA, Willenberg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Publié dans: New England Journal of Medicine, Numéro 374/12, 2016, Page(s) 1134-1144, ISSN 0028-4793 Éditeur: Massachusetts Medical Society DOI: 10.1056/NEJMoa1507652 Genetic variants linked to education predict longevity Auteurs: Riccardo E. Marioni, Stuart J. Ritchie, Peter K. Joshi, Saskia P. Hagenaars, Aysu Okbay, Krista Fischer, Mark J. Adams, W. David Hill, Gail Davies, Reka Nagy, Carmen Amador, Kristi Läll, Andres Metspalu, David C. Liewald, Archie Campbell, James F. Wilson, Caroline Hayward, Tõnu Esko, David J. Porteous, Catharine R. Gale, Ian J. Deary Publié dans: Proceedings of the National Academy of Sciences, Numéro 113/47, 2016, Page(s) 13366-13371, ISSN 0027-8424 Éditeur: National Academy of Sciences DOI: 10.1073/pnas.1605334113 Genomic analyses inform on migration events during the peopling of Eurasia Auteurs: Luca Pagani, Daniel John Lawson, Evelyn Jagoda, Alexander Mörseburg, Anders Eriksson, Mario Mitt, Florian Clemente, Georgi Hudjashov, Michael DeGiorgio, Lauri Saag, Jeffrey D. Wall, Alexia Cardona, Reedik Mägi, Melissa A. Wilson Sayres, Sarah Kaewert, Charlotte Inchley, Christiana L. Scheib, Mari Järve, Monika Karmin, Guy S. Jacobs, Tiago Antao, Florin Mircea Iliescu, Alena Kushniarevich, Qasim Publié dans: Nature, Numéro 538/7624, 2016, Page(s) 238-242, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature19792 De novo exonic mutation in MYH7 gene leading to exon skipping in a patient with early onset muscular weakness and fiber-type disproportion Auteurs: Sander Pajusalu, Inga Talvik, Klari Noormets, Tiina Talvik, Haide Põder, Kairit Joost, Sanna Puusepp, Andres Piirsoo, Werner Stenzel, Hans H. Goebel, Tiit Nikopensius, Tarmo Annilo, Margit Nõukas, Andres Metspalu, Katrin Õunap, Tiia Reimand Publié dans: Neuromuscular Disorders, Numéro 26/3, 2016, Page(s) 236-239, ISSN 0960-8966 Éditeur: Elsevier BV DOI: 10.1016/j.nmd.2015.11.011 A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape Auteurs: Janina S. Ried, Janina Jeff M., Audrey Y. Chu, Jennifer L. Bragg-Gresham, Jenny van Dongen, Jennifer E. Huffman, Tarunveer S. Ahluwalia, Gemma Cadby, Niina Eklund, Joel Eriksson, Tõnu Esko, Mary F. Feitosa, Anuj Goel, Mathias Gorski, Caroline Hayward, Nancy L. Heard-Costa, Anne U. Jackson, Eero Jokinen, Stavroula Kanoni, Kati Kristiansson, Zoltán Kutalik, Jari Lahti, Jian'an Luan, Reedik Mägi, Publié dans: Nature Communications, Numéro 7, 2016, Page(s) 13357, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms13357 Metabolites of milk intake: a metabolomic approach in UK twins with findings replicated in two European cohorts Auteurs: Tess Pallister, Toomas Haller, Barbara Thorand, Elisabeth Altmaier, Aedin Cassidy, Tiphaine Martin, Amy Jennings, Robert P. Mohney, Christian Gieger, Alexander MacGregor, Gabi Kastenmüller, Andres Metspalu, Tim D. Spector, Cristina Menni Publié dans: European Journal of Nutrition, 2016, Page(s) 1-13, ISSN 1436-6207 Éditeur: Dr. Dietrich Steinkopff Verlag DOI: 10.1007/s00394-016-1278-x Whole-genome expression analysis reveals genes associated with treatment response to escitalopram in major depression Auteurs: Kristi Pettai, Lili Milani, Anu Tammiste, Urmo Võsa, Raivo Kolde, Triin Eller, David Nutt, Andres Metspalu, Eduard Maron Publié dans: European Neuropsychopharmacology, Numéro 26/9, 2016, Page(s) 1475-1483, ISSN 0924-977X Éditeur: Elsevier BV DOI: 10.1016/j.euroneuro.2016.06.007 Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function Auteurs: Cristian Pattaro, Alexander Teumer, Mathias Gorski, Audrey Y. Chu, Man Li, Vladan Mijatovic, Maija Garnaas, Adrienne Tin, Rossella Sorice, Yong Li, Daniel Taliun, Matthias Olden, Meredith Foster, Qiong Yang, Ming-Huei Chen, Tune H. Pers, Andrew D. Johnson, Yi-An Ko, Christian Fuchsberger, Bamidele Tayo, Michael Nalls, Mary F. Feitosa, Aaron Isaacs, Abbas Dehghan, Pio d’Adamo, Adebowale Adeyemo, Publié dans: Nature Communications, Numéro 7, 2016, Page(s) 10023, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms10023 Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis Auteurs: Linda M. Polfus, Rajiv K. Khajuria, Ursula M. Schick, Nathan Pankratz, Raha Pazoki, Jennifer A. Brody, Ming-Huei Chen, Paul L. Auer, James S. Floyd, Jie Huang, Leslie Lange, Frank J.A. van Rooij, Richard A. Gibbs, Ginger Metcalf, Donna Muzny, Narayanan Veeraraghavan, Klaudia Walter, Lu Chen, Lisa Yanek, Lewis C. Becker, Gina M. Peloso, Aoi Wakabayashi, Mart Kals, Andres Metspalu, Tõnu Publié dans: The American Journal of Human Genetics, Numéro 99/2, 2016, Page(s) 481-488, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2016.06.016 Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture Auteurs: Philip E. Stuart, Rajan P. Nair, Lam C. Tsoi, Trilokraj Tejasvi, Sayantan Das, Hyun Min Kang, Eva Ellinghaus, Vinod Chandran, Kristina Callis-Duffin, Robert Ike, Yanming Li, Xiaoquan Wen, Charlotta Enerbäck, Johann E. Gudjonsson, Sulev Kõks, Külli Kingo, Tõnu Esko, Ulrich Mrowietz, Andre Reis, H. Erich Wichmann, Christian Gieger, Per Hoffmann, Markus M. Nöthen, Juliane Winkelmann, Manf Publié dans: The American Journal of Human Genetics, Numéro 97/6, 2015, Page(s) 816-836, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2015.10.019 Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium Auteurs: Stéphanie M. van den Berg, Marleen H. M. de Moor, Karin J. H. Verweij, Robert F. Krueger, Michelle Luciano, Alejandro Arias Vasquez, Lindsay K. Matteson, Jaime Derringer, Tõnu Esko, Najaf Amin, Scott D. Gordon, Narelle K. Hansell, Amy B. Hart, Ilkka Seppälä, Jennifer E. Huffman, Bettina Konte, Jari Lahti, Minyoung Lee, Mike Miller, Teresa Nutile, Toshiko Tanaka, Alexander Teumer, Alexander Vik Publié dans: Behavior Genetics, Numéro 46/2, 2016, Page(s) 170-182, ISSN 0001-8244 Éditeur: Kluwer Academic Publishers DOI: 10.1007/s10519-015-9735-5 Schizophrenia risk from complex variation of complement component 4 Auteurs: Aswin Sekar, Allison R. Bialas, Heather de Rivera, Avery Davis, Timothy R. Hammond, Nolan Kamitaki, Katherine Tooley, Jessy Presumey, Matthew Baum, Vanessa Van Doren, Giulio Genovese, Samuel A. Rose, Robert E. Handsaker, Mark J. Daly, Michael C. Carroll, Beth Stevens, Steven A. McCarroll Publié dans: Nature, Numéro 530/7589, 2016, Page(s) 177-183, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature16549 Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota Auteurs: Jun Wang, Louise B Thingholm, Jurgita Skiecevičienė, Philipp Rausch, Martin Kummen, Johannes R Hov, Frauke Degenhardt, Femke-Anouska Heinsen, Malte C Rühlemann, Silke Szymczak, Kristian Holm, Tönu Esko, Jun Sun, Mihaela Pricop-Jeckstadt, Samer Al-Dury, Pavol Bohov, Jörn Bethune, Felix Sommer, David Ellinghaus, Rolf K Berge, Matthias Hübenthal, Manja Koch, Karin Schwarz, Gerald Rimbach, Patri Publié dans: Nature Genetics, Numéro 48/11, 2016, Page(s) 1396-1406, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3695 Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci Auteurs: Geoffrey A. Walford, Stefan Gustafsson, Denis Rybin, Alena Stančáková, Han Chen, Ching-Ti Liu, Jaeyoung Hong, Richard A. Jensen, Ken Rice, Andrew P. Morris, Reedik Mägi, Anke Tönjes, Inga Prokopenko, Marcus E. Kleber, Graciela Delgado, Günther Silbernagel, Anne U. Jackson, Emil V. Appel, Niels Grarup, Joshua P. Lewis, May E. Montasser, Claes Landenvall, Harald Staiger, Jian’an Luan, Timoth Publié dans: Diabetes, Numéro 65/10, 2016, Page(s) 3200-3211, ISSN 0012-1797 Éditeur: American Diabetes Association DOI: 10.2337/db16-0199 Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data Auteurs: Susanne Vogt, Simone Wahl, Johannes Kettunen, Susanne Breitner, Gabi Kastenmüller, Christian Gieger, Karsten Suhre, Melanie Waldenberger, Jürgen Kratzsch, Markus Perola, Veikko Salomaa, Stefan Blankenberg, Tanja Zeller, Pasi Soininen, Antti J Kangas, Annette Peters, Harald Grallert, Mika Ala-Korpela, Barbara Thorand Publié dans: International Journal of Epidemiology, Numéro 45/5, 2016, Page(s) 1469-1481, ISSN 0300-5771 Éditeur: Oxford University Press DOI: 10.1093/ije/dyw222 Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies Auteurs: R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler Publié dans: Clinical Pharmacology & Therapeutics, Numéro 101/5, 2017, Page(s) 684-695, ISSN 0009-9236 Éditeur: Nature Publishing Group DOI: 10.1002/cpt.540 Identifying Cases of Type 2 Diabetes in Heterogeneous Data Sources: Strategy from the EMIF Project Auteurs: Giuseppe Roberto, Ingrid Leal, Naveed Sattar, A. Katrina Loomis, Paul Avillach, Peter Egger, Rients van Wijngaarden, David Ansell, Sulev Reisberg, Mari-Liis Tammesoo, Helene Alavere, Alessandro Pasqua, Lars Pedersen, James Cunningham, Lara Tramontan, Miguel A. Mayer, Ron Herings, Preciosa Coloma, Francesco Lapi, Miriam Sturkenboom, Johan van der Lei, Martijn J. Schuemie, Peter Rijnbeek, Rosa Gini Publié dans: PLOS ONE, Numéro 11/8, 2016, Page(s) e0160648, ISSN 1932-6203 Éditeur: Public Library of Science DOI: 10.1371/journal.pone.0160648 Sequence variation in nuclear ribosomal small subunit, internal transcribed spacer and large subunit regions of Rhizophagus irregularis and Gigaspora margarita is high and isolate-dependent Auteurs: Odile Thiéry, Martti Vasar, Teele Jairus, John Davison, Christophe Roux, Paula-Ann Kivistik, Andres Metspalu, Lili Milani, Ülle Saks, Mari Moora, Martin Zobel, Maarja Öpik Publié dans: Molecular Ecology, Numéro 25/12, 2016, Page(s) 2816-2832, ISSN 0962-1083 Éditeur: Blackwell Publishing Inc. DOI: 10.1111/mec.13655 52 Genetic Loci Influencing Myocardial Mass Auteurs: Pim van der Harst, Jessica van Setten, Niek Verweij, Georg Vogler, Lude Franke, Matthew T. Maurano, Xinchen Wang, Irene Mateo Leach, Mark Eijgelsheim, Nona Sotoodehnia, Caroline Hayward, Rossella Sorice, Osorio Meirelles, Leo-Pekka Lyytikäinen, Ozren Polašek, Toshiko Tanaka, Dan E. Arking, Sheila Ulivi, Stella Trompet, Martina Müller-Nurasyid, Albert V. Smith, Marcus Dörr, Kathleen F. Kerr, Ja Publié dans: Journal of the American College of Cardiology, Numéro 68/13, 2016, Page(s) 1435-1448, ISSN 0735-1097 Éditeur: Elsevier BV DOI: 10.1016/j.jacc.2016.07.729 Genome-wide genetic homogeneity between sexes and populations for human height and body mass index Auteurs: Jian Yang, Andrew Bakshi, Zhihong Zhu, Gibran Hemani, Anna A.E. Vinkhuyzen, Ilja M. Nolte, Jana V. van Vliet-Ostaptchouk, Harold Snieder, Tonu Esko, Lili Milani, Reedik Mägi, Andres Metspalu, Anders Hamsten, Patrik K.E. Magnusson, Nancy L. Pedersen, Erik Ingelsson, Peter M. Visscher Publié dans: Human Molecular Genetics, Numéro 24/25, 2015, Page(s) 7445-7449, ISSN 0964-6906 Éditeur: Oxford University Press DOI: 10.1093/hmg/ddv443 Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2 Auteurs: Jennifer J. Ware, Xiangning Chen, Jacqueline Vink, Anu Loukola, Camelia Minica, Rene Pool, Yuri Milaneschi, Massimo Mangino, Cristina Menni, Jingchun Chen, Roseann E. Peterson, Kirsi Auro, Leo-Pekka Lyytikäinen, Juho Wedenoja, Alexander I. Stiby, Gibran Hemani, Gonneke Willemsen, Jouke Jan Hottenga, Tellervo Korhonen, Markku Heliövaara, Markus Perola, Richard J. Rose, Lavinia Paternoster, Nic Ti Publié dans: Scientific Reports, Numéro 6/1, 2016, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/srep20092 Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk Auteurs: Weifei Zhu, Jill C. Gregory, Elin Org, Jennifer A. Buffa, Nilaksh Gupta, Zeneng Wang, Lin Li, Xiaoming Fu, Yuping Wu, Margarete Mehrabian, R. Balfour Sartor, Thomas M. McIntyre, Roy L. Silverstein, W.H. Wilson Tang, Joseph A. DiDonato, J. Mark Brown, Aldons J. Lusis, Stanley L. Hazen Publié dans: Cell, Numéro 165/1, 2016, Page(s) 111-124, ISSN 0092-8674 Éditeur: Cell Press DOI: 10.1016/j.cell.2016.02.011 KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference Auteurs: Gunter Schumann, Chunyu Liu, Paul O’Reilly, He Gao, Parkyong Song, Bing Xu, Barbara Ruggeri, Najaf Amin, Tianye Jia, Sarah Preis, Marcelo Segura Lepe, Shizuo Akira, Caterina Barbieri, Sebastian Baumeister, Stephane Cauchi, Toni-Kim Clarke, Stefan Enroth, Krista Fischer, Jenni Hällfors, Sarah E. Harris, Saskia Hieber, Edith Hofer, Jouke-Jan Hottenga, Åsa Johansson, Peter K. Joshi, Niina Kaartin Publié dans: Proceedings of the National Academy of Sciences, Numéro 113/50, 2016, Page(s) 14372-14377, ISSN 0027-8424 Éditeur: National Academy of Sciences DOI: 10.1073/pnas.1611243113 Effect of characteristics of women on attendance in blind and non-blind randomised trials: analysis of recruitment data from the EPHT Trial Auteurs: Piret Veerus, Krista Fischer, Elina Hemminki, Sirpa-Liisa Hovi, Matti Hakama Publié dans: BMJ Open, Numéro 6/10, 2016, Page(s) e011099, ISSN 2044-6055 Éditeur: BMJ Publishing Group DOI: 10.1136/bmjopen-2016-011099 ITPR1 gene p.Val1553Met mutation in Russian family with mild Spinocerebellar ataxia Auteurs: M. I. Shadrina, M. V. Shulskaya, S. A. Klyushnikov, T. Nikopensius, M. Nelis, P. A. Kivistik, A. A. Komar, S. A. Limborska, S. N. Illarioshkin, P. A. Slominsky Publié dans: Cerebellum & Ataxias, Numéro 3/1, 2016, Page(s) 1-6, ISSN 2053-8871 Éditeur: Springer Nature DOI: 10.1186/s40673-016-0040-8 Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase Auteurs: Peter Würtz, Qin Wang, Pasi Soininen, Antti J. Kangas, Ghazaleh Fatemifar, Tuulia Tynkkynen, Mika Tiainen, Markus Perola, Therese Tillin, Alun D. Hughes, Pekka Mäntyselkä, Mika Kähönen, Terho Lehtimäki, Naveed Sattar, Aroon D. Hingorani, Juan-Pablo Casas, Veikko Salomaa, Mika Kivimäki, Marjo-Riitta Järvelin, George Davey Smith, Mauno Vanhala, Debbie A. Lawlor, Olli T. Raitakari, Nish Chatu Publié dans: Journal of the American College of Cardiology, Numéro 67/10, 2016, Page(s) 1200-1210, ISSN 0735-1097 Éditeur: Elsevier BV DOI: 10.1016/j.jacc.2015.12.060 C14orf132 gene is possibly related to extremely low birth weight Auteurs: Airi Tiirats, Triin Viltrop, Margit Nõukas, Ene Reimann, Andres Salumets, Sulev Kõks Publié dans: BMC Genetics, Numéro 17/1, 2016, ISSN 1471-2156 Éditeur: BioMed Central DOI: 10.1186/s12863-016-0439-5 Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits Auteurs: Alexander Teumer, Qibin Qi, Maria Nethander, Hugues Aschard, Stefania Bandinelli, Marian Beekman, Sonja I. Berndt, Martin Bidlingmaier, Linda Broer, Anne Cappola, Gian Paolo Ceda, Stephen Chanock, Ming-Huei Chen, Tai C. Chen, Yii-Der Ida Chen, Jonathan Chung, Fabiola Del Greco Miglianico, Joel Eriksson, Luigi Ferrucci, Nele Friedrich, Carsten Gnewuch, Mark O. Goodarzi, Niels Grarup, Tingwei Guo, E Publié dans: Aging Cell, Numéro 15/5, 2016, Page(s) 811-824, ISSN 1474-9718 Éditeur: Blackwell Publishing Inc. DOI: 10.1111/acel.12490 Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease Auteurs: P. Zanoni, S. A. Khetarpal, D. B. Larach, W. F. Hancock-Cerutti, J. S. Millar, M. Cuchel, S. DerOhannessian, A. Kontush, P. Surendran, D. Saleheen, S. Trompet, J. W. Jukema, A. De Craen, P. Deloukas, N. Sattar, I. Ford, C. Packard, A. a. S. Majumder, D. S. Alam, E. Di Angelantonio, G. Abecasis, R. Chowdhury, J. Erdmann, B. G. Nordestgaard, S. F. Nielsen, A. Tybjaerg-Hansen, R. F. Schmidt, K. Kuula Publié dans: Science, Numéro 351/6278, 2016, Page(s) 1166-1171, ISSN 0036-8075 Éditeur: American Association for the Advancement of Science DOI: 10.1126/science.aad3517 The Effects of Intensive Weight Reduction on Body Composition and Serum Hormones in Female Fitness Competitors Auteurs: Juha J. Hulmi, Ville Isola, Marianna Suonpää, Neea J. Järvinen, Marja Kokkonen, Annika Wennerström, Kai Nyman, Markus Perola, Juha P. Ahtiainen, Keijo Häkkinen Publié dans: Frontiers in Physiology, Numéro 7, 2017, Page(s) 1-16, ISSN 1664-042X Éditeur: Frontiers Research Foundation DOI: 10.3389/fphys.2016.00689 DNA breaks and chromatin structural changes enhance the transcription of autoimmune regulator target genes Auteurs: Mithu Guha, Mario Saare, Julia Maslovskaja, Kai Kisand, Ingrid Liiv, Uku Haljasorg, Tõnis Tasa, Andres Metspalu, Lili Milani, Pärt Peterson Publié dans: Journal of Biological Chemistry, Numéro 292/16, 2017, Page(s) 6542-6554, ISSN 0021-9258 Éditeur: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.M116.764704 Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects Auteurs: Christian R Marshall, Daniel P Howrigan, Daniele Merico, Bhooma Thiruvahindrapuram, Wenting Wu, Douglas S Greer, Danny Antaki, Aniket Shetty, Peter A Holmans, Dalila Pinto, Madhusudan Gujral, William M Brandler, Dheeraj Malhotra, Zhouzhi Wang, Karin V Fuentes Fajarado, Michelle S Maile, Stephan Ripke, Ingrid Agartz, Margot Albus, Madeline Alexander, Farooq Amin, Joshua Atkins, Silviu A Bacanu, Ric Publié dans: Nature Genetics, Numéro 49/1, 2016, Page(s) 27-35, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3725 The Genetic Architecture of Gene Expression in Peripheral Blood Auteurs: Luke R. Lloyd-Jones, Alexander Holloway, Allan McRae, Jian Yang, Kerrin Small, Jing Zhao, Biao Zeng, Andrew Bakshi, Andres Metspalu, Manolis Dermitzakis, Greg Gibson, Tim Spector, Grant Montgomery, Tonu Esko, Peter M. Visscher, Joseph E. Powell Publié dans: The American Journal of Human Genetics, Numéro 100/2, 2017, Page(s) 371, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2017.01.026 Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom Auteurs: Himanshu Chheda, Priit Palta, Matti Pirinen, Shane McCarthy, Klaudia Walter, Seppo Koskinen, Veikko Salomaa, Mark Daly, Richard Durbin, Aarno Palotie, Tero Aittokallio, Samuli Ripatti Publié dans: European Journal of Human Genetics, Numéro 25/4, 2017, Page(s) 477-484, ISSN 1018-4813 Éditeur: Natue Publishing Group DOI: 10.1038/ejhg.2016.205 MARV: a tool for genome-wide multi-phenotype analysis of rare variants Auteurs: Marika Kaakinen, Reedik Mägi, Krista Fischer, Jani Heikkinen, Marjo-Riitta Järvelin, Andrew P. Morris, Inga Prokopenko Publié dans: BMC Bioinformatics, Numéro 18/1, 2017, Page(s) 1-8, ISSN 1471-2105 Éditeur: BioMed Central DOI: 10.1186/s12859-017-1530-2 Metabolomic profiles as reliable biomarkers of dietary composition Auteurs: Tõnu Esko, Joel N Hirschhorn, Henry A Feldman, Yu-Han H Hsu, Amy A Deik, Clary B Clish, Cara B Ebbeling, David S Ludwig Publié dans: The American Journal of Clinical Nutrition, Numéro 105/3, 2017, Page(s) 547-554, ISSN 0002-9165 Éditeur: American Society for Clinical Nutrition, Inc. DOI: 10.3945/ajcn.116.144428 Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel Auteurs: Mario Mitt, Mart Kals, Kalle Pärn, Stacey B Gabriel, Eric S Lander, Aarno Palotie, Samuli Ripatti, Andrew P Morris, Andres Metspalu, Tõnu Esko, Reedik Mägi, Priit Palta Publié dans: European Journal of Human Genetics, 2017, Page(s) 1-8, ISSN 1018-4813 Éditeur: Natue Publishing Group DOI: 10.1038/ejhg.2017.51 A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Auteurs: Alisa Manning, Heather M Highland, Jessica Gasser, Xueling Sim, Taru Tukiainen, Pierre Fontanillas, Niels Grarup, Manuel A Rivas, Anubha Mahajan, Adam E Locke, Pablo Cingolani, Tune H Pers, Ana Viñuela, Andrew A Brown, Ying Wu, Jason Flannick, Christian Fuchsberger, Eric R Gamazon, Kyle J Gaulton, Hae Kyung Im, Tanya M Teslovich, Thomas W Blackwell, Jette Bork-Jensen, Noël P Burtt, Yuhui Chen, T Publié dans: Diabetes, 2017, Page(s) db161329, ISSN 0012-1797 Éditeur: American Diabetes Association DOI: 10.2337/db16-1329 Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants Auteurs: Bin Zhou, James Bentham, Mariachiara Di Cesare, Honor Bixby, Goodarz Danaei, Melanie J Cowan, Christopher J Paciorek, Gitanjali Singh, Kaveh Hajifathalian, James E Bennett, Cristina Taddei, Ver Bilano, Rodrigo M Carrillo-Larco, Shirin Djalalinia, Shahab Khatibzadeh, Charles Lugero, Niloofar Peykari, Wan Zhu Zhang, Yuan Lu, Gretchen A Stevens, Leanne M Riley, Pascal Bovet, Paul Elliott, Dongfeng Gu Publié dans: The Lancet, Numéro 389/10064, 2017, Page(s) 37-55, ISSN 0140-6736 Éditeur: The Lancet Publishing Group DOI: 10.1016/S0140-6736(16)31919-5 Human basonuclin 2 up-regulates a cascade set of interferon-stimulated genes with anti-cancerous properties in a lung cancer model Auteurs: Egon Urgard, Anu Reigo, Eva Reinmaa, Ana Rebane, Andres Metspalu Publié dans: Cancer Cell International, Numéro 17/1, 2017, Page(s) 1-10, ISSN 1475-2867 Éditeur: BioMed Central DOI: 10.1186/s12935-017-0394-x Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity Auteurs: Simone Wahl, Alexander Drong, Benjamin Lehne, Marie Loh, William R. Scott, Sonja Kunze, Pei-Chien Tsai, Janina S. Ried, Weihua Zhang, Youwen Yang, Sili Tan, Giovanni Fiorito, Lude Franke, Simonetta Guarrera, Silva Kasela, Jennifer Kriebel, Rebecca C. Richmond, Marco Adamo, Uzma Afzal, Mika Ala-Korpela, Benedetta Albetti, Ole Ammerpohl, Jane F. Apperley, Marian Beekman, Pier Alberto Bertazzi, S. Lu Publié dans: Nature, Numéro 541/7635, 2016, Page(s) 81-86, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature20784 Rare and low-frequency coding variants alter human adult height Auteurs: Eirini Marouli, Mariaelisa Graff, Carolina Medina-Gomez, Ken Sin Lo, Andrew R. Wood, Troels R. Kjaer, Rebecca S. Fine, Yingchang Lu, Claudia Schurmann, Heather M. Highland, Sina Rüeger, Gudmar Thorleifsson, Anne E. Justice, David Lamparter, Kathleen E. Stirrups, Valérie Turcot, Kristin L. Young, Thomas W. Winkler, Tõnu Esko, Tugce Karaderi, Adam E. Locke, Nicholas G. D. Masca, Maggie C. Y. Ng, Publié dans: Nature, Numéro 542/7640, 2017, Page(s) 186-190, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature21039 SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes Auteurs: Reedik Mägi, Yury V. Suleimanov, Geraldine M. Clarke, Marika Kaakinen, Krista Fischer, Inga Prokopenko, Andrew P. Morris Publié dans: BMC Bioinformatics, Numéro 18/1, 2017, Page(s) 1-8, ISSN 1471-2105 Éditeur: BioMed Central DOI: 10.1186/s12859-016-1437-3 Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk Auteurs: Helen R Warren, Evangelos Evangelou, Claudia P Cabrera, He Gao, Meixia Ren, Borbala Mifsud, Ioanna Ntalla, Praveen Surendran, Chunyu Liu, James P Cook, Aldi T Kraja, Fotios Drenos, Marie Loh, Niek Verweij, Jonathan Marten, Ibrahim Karaman, Marcelo P Segura Lepe, Paul F O'Reilly, Joanne Knight, Harold Snieder, Norihiro Kato, Jiang He, E Shyong Tai, M Abdullah Said, David Porteous, Maris Alver, Neil Publié dans: Nature Genetics, Numéro 49/3, 2017, Page(s) 403-415, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3768 Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study Auteurs: Bendik S Winsvold, Priit Palta, Else Eising, Christian M Page, Arn MJM van den Maagdenberg, Aarno Palotie, John-Anker Zwart Publié dans: Cephalalgia, 2016, Page(s) 033310241769011, ISSN 0333-1024 Éditeur: SAGE Publications DOI: 10.1177/0333102417690111 Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease Auteurs: Thomas R. Webb, Jeanette Erdmann, Kathleen E. Stirrups, Nathan O. Stitziel, Nicholas G.D. Masca, Henning Jansen, Stavroula Kanoni, Christopher P. Nelson, Paola G. Ferrario, Inke R. König, John D. Eicher, Andrew D. Johnson, Stephen E. Hamby, Christer Betsholtz, Arno Ruusalepp, Oscar Franzén, Eric E. Schadt, Johan L.M. Björkegren, Peter E. Weeke, Paul L. Auer, Ursula M. Schick, Yingchang Lu, He Z Publié dans: Journal of the American College of Cardiology, Numéro 69/7, 2017, Page(s) 823-836, ISSN 0735-1097 Éditeur: Elsevier BV DOI: 10.1016/j.jacc.2016.11.056 Replicability and Robustness of Genome-Wide-Association Studies for Behavioral Traits Auteurs: C. A. Rietveld, D. Conley, N. Eriksson, T. Esko, S. E. Medland, A. A. E. Vinkhuyzen, J. Yang, J. D. Boardman, C. F. Chabris, C. T. Dawes, B. W. Domingue, D. A. Hinds, M. Johannesson, A. K. Kiefer, D. Laibson, P. K. E. Magnusson, J. L. Mountain, S. Oskarsson, O. Rostapshova, A. Teumer, J. Y. Tung, P. M. Visscher, D. J. Benjamin, D. Cesarini, P. D. Koellinger, N. Eriksson, D. A. Hinds, A. K. Kiefer, J. L. Mountain, J. Y. Tung, S. E. Medland, A. A. E. Vinkhuyzen, J. Yang, P. M. Visscher, D. Conley, J. D. Boardman, C. T. Dawes, B. W. Domingue, C. A. Rietveld, D. J. Benjamin, D. Cesarini, P. D. Koellinger, D. Conley, N. Eriksson, T. Esko, C. F. Chabris, M. Johannesson, D. Laibson, P. K. E. Magnusson, S. Oskarsson, O. Rostapshova, A. Teumer, P. M. Visscher, D. J. Benjamin, D. Cesarini, P. D. Koellinger Publié dans: Psychological Science, Numéro 09567976, 2014, Page(s) 1975-1986, ISSN 0956-7976 Éditeur: SAGE Publications DOI: 10.1177/0956797614545132 CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing Auteurs: Liina Tserel, Maia Limbach, Mario Saare, Kai Kisand, Andres Metspalu, Lili Milani, Pärt Peterson Publié dans: Immunity & Ageing, Numéro 17424933, 2014, Page(s) 1, ISSN 1742-4933 Éditeur: BioMed Central DOI: 10.1186/1742-4933-11-1 An epidemiological perspective of personalized medicine: the Estonian experience Auteurs: L. Milani, L. Leitsalu, A. Metspalu Publié dans: Journal of Internal Medicine, Numéro 09546820, 2015, Page(s) 188-200, ISSN 0954-6820 Éditeur: Blackwell Publishing Inc. DOI: 10.1111/joim.12320 Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression Auteurs: A. Tammiste, T. Jiang, K. Fischer, R. Magi, K. Krjutskov, K. Pettai, T. Esko, Y. Li, K. E. Tansey, L. S. Carroll, R. Uher, P. McGuffin, U. Vosa, N. Tsernikova, A. Saria, P. C. Ng, T. Eller, V. Vasar, D. J. Nutt, E. Maron, J. Wang, A. Metspalu Publié dans: Journal of Psychopharmacology, Numéro 02698811, 2013, Page(s) 915-920, ISSN 0269-8811 Éditeur: SAGE Publications DOI: 10.1177/0269881113499829 Genetic studies of body mass index yield new insights for obesity biology Auteurs: Adam E. Locke, Bratati Kahali, Sonja I. Berndt, Anne E. Justice, Tune H. Pers, Felix R. Day, Corey Powell, Sailaja Vedantam, Martin L. Buchkovich, Jian Yang, Damien C. Croteau-Chonka, Tonu Esko, Tove Fall, Teresa Ferreira, Stefan Gustafsson, Zoltán Kutalik, Jian’an Luan, Reedik Mägi, Joshua C. Randall, Thomas W. Winkler, Andrew R. Wood, Tsegaselassie Workalemahu, Jessica D. Faul, Jennifer A. Smith, Jing Hua Zhao, Wei Zhao, Jin Chen, Rudolf Fehrmann, Åsa K. Hedman, Juha Karjalainen, Ellen M. Schmidt, Devin Absher, Najaf Amin, Denise Anderson, Marian Beekman, Jennifer L. Bolton, Jennifer L. Bragg-Gresham, Steven Buyske, Ayse Demirkan, Guohong Deng, Georg B. Ehret, Bjarke Feenstra, Mary F. Feitosa, Krista Fischer, Anuj Goel, Jian Gong, Anne U. Jackson, Stavroula Kanoni, Marcus E. Kleber, Kati Kristiansson, Unhee Lim, Vaneet Lotay, Massimo Mangino, Irene Mateo Leach, Carolina Medina-Gomez, Sarah E. Medland, Michael A. Nalls, Cameron D. Palmer, Dorota Pasko, Sonali Pechlivanis, Marjolein J. Peters, Inga Prokopenko, Dmitry Shungin, Alena Stančáková, Rona J. Strawbridge, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sander W. van der Laan, Jessica van Setten, Jana V. Van Vliet-Ostaptchouk, Zhaoming Wang, Loïc Yengo, Weihua Zhang, Aaron Isaacs, Eva Albrecht, Johan Ärnlöv, Gillian M. Arscott, Antony P. Attwood, Stefania Bandinelli, Amy Barrett, Isabelita N. Bas, Claire Bellis, Amanda J. Bennett, Christian Berne, Roza Blagieva, Matthias Blüher, Stefan Böhringer, Lori L. Bonnycastle, Yvonne Böttcher, Heather A. Boyd, Marcel Bruinenberg, Ida H. Caspersen, Yii-Der Ida Chen, Robert Clarke, E. Warwick Daw, Anton J. M. de Craen, Graciela Delgado, Maria Dimitriou, Alex S. F. Doney, Niina Eklund, Karol Estrada, Elodie Eury, Lasse Folkersen, Ross M. Fraser, Melissa E. Garcia, Frank Geller, Vilmantas Giedraitis, Bruna Gigante, Alan S. Go, Alain Golay, Alison H. Goodall, Scott D. Gordon, Mathias Gorski, Hans-Jörgen Grabe, Harald Grallert, Tanja B. Grammer, Jürgen Gräßler, Henrik Grönberg, Christopher J. Groves, Gaëlle Gusto, Jeffrey Haessler, Per Hall, Toomas Haller, Goran Hallmans, Catharina A. Hartman, Maija Hassinen, Caroline Hayward, Nancy L. Heard-Costa, Quinta Helmer, Christian Hengstenberg, Oddgeir Holmen, Jouke-Jan Hottenga, Alan L. James, Janina M. Jeff, Åsa Johansson, Jennifer Jolley, Thorhildur Juliusdottir, Leena Kinnunen, Wolfgang Koenig, Markku Koskenvuo, Wolfgang Kratzer, Jaana Laitinen, Claudia Lamina, Karin Leander, Nanette R. Lee, Peter Lichtner, Lars Lind, Jaana Lindström, Ken Sin Lo, Stéphane Lobbens, Roberto Lorbeer, Yingchang Lu, François Mach, Patrik K. E. Magnusson, Anubha Mahajan, Wendy L. McArdle, Stela McLachlan, Cristina Menni, Sigrun Merger, Evelin Mihailov, Lili Milani, Alireza Moayyeri, Keri L. Monda, Mario A. Morken, Antonella Mulas, Gabriele Müller, Martina Müller-Nurasyid, Arthur W. Musk, Ramaiah Nagaraja, Markus M. Nöthen, Ilja M. Nolte, Stefan Pilz, Nigel W. Rayner, Frida Renstrom, Rainer Rettig, Janina S. Ried, Stephan Ripke, Neil R. Robertson, Lynda M. Rose, Serena Sanna, Hubert Scharnagl, Salome Scholtens, Fredrick R. Schumacher, William R. Scott, Thomas Seufferlein, Jianxin Shi, Albert Vernon Smith, Joanna Smolonska, Alice V. Stanton, Valgerdur Steinthorsdottir, Kathleen Stirrups, Heather M. Stringham, Johan Sundström, Morris A. Swertz, Amy J. Swift, Ann-Christine Syvänen, Sian-Tsung Tan, Bamidele O. Tayo, Barbara Thorand, Gudmar Thorleifsson, Jonathan P. Tyrer, Hae-Won Uh, Liesbeth Vandenput, Frank C. Verhulst, Sita H. Vermeulen, Niek Verweij, Judith M. Vonk, Lindsay L. Waite, Helen R. Warren, Dawn Waterworth, Michael N. Weedon, Lynne R. Wilkens, Christina Willenborg, Tom Wilsgaard, Mary K. Wojczynski, Andrew Wong, Alan F. Wright, Qunyuan Zhang, Eoin P. Brennan, Murim Choi, Zari Dastani, Alexander W. Drong, Per Eriksson, Anders Franco-Cereceda, Jesper R. Gådin, Ali G. Gharavi, Michael E. Goddard, Robert E. Handsaker, Jinyan Huang, Fredrik Karpe, Sekar Kathiresa Publié dans: Nature, Numéro 00280836, 2015, Page(s) 197-206, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature14177 Rare coding variants and X-linked loci associated with age at menarche Auteurs: Kathryn L. Lunetta, Felix R. Day, Patrick Sulem, Katherine S. Ruth, Joyce Y. Tung, David A. Hinds, Tõnu Esko, Cathy E. Elks, Elisabeth Altmaier, Chunyan He, Jennifer E. Huffman, Evelin Mihailov, Eleonora Porcu, Antonietta Robino, Lynda M. Rose, Ursula M. Schick, Lisette Stolk, Alexander Teumer, Deborah J. Thompson, Michela Traglia, Carol A. Wang, Laura M. Yerges-Armstrong, Antonis C. Antoniou, Caterina Barbieri, Andrea D. Coviello, Francesco Cucca, Ellen W. Demerath, Alison M. Dunning, Ilaria Gandin, Megan L. Grove, Daniel F. Gudbjartsson, Lynne J. Hocking, Albert Hofman, Jinyan Huang, Rebecca D. Jackson, David Karasik, Jennifer Kriebel, Ethan M. Lange, Leslie A. Lange, Claudia Langenberg, Xin Li, Jian'an Luan, Reedik Mägi, Alanna C. Morrison, Sandosh Padmanabhan, Ailith Pirie, Ozren Polasek, David Porteous, Alex P. Reiner, Fernando Rivadeneira, Igor Rudan, Cinzia F. Sala, David Schlessinger, Robert A. Scott, Doris Stöckl, Jenny A. Visser, Uwe Völker, Diego Vozzi, James G. Wilson, Marek Zygmunt, Nita G. Forouhi, Nicola D. Kerrison, Stephen J. Sharp, Matt Sims, Inês Barroso, Panos Deloukas, Mark I. McCarthy, Larraitz Arriola, Beverley Balkau, Aurelio Barricarte, Heiner Boeing, Paul W. Franks, Carlos Gonzalez, Sara Grioni, Rudolf Kaaks, Timothy J. Key, Carmen Navarro, Peter M. Nilsson, Kim Overvad, Domenico Palli, Salvatore Panico, J Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, María‐José Sánchez, Nadia Slimani, Anne Tjonneland, Rosario Tumino, Daphne L. van der A, Yvonne T. van der Schouw, Elio Riboli, Blair H. Smith, Archie Campbell, Ian J. Deary, Andrew M. McIntosh, Eric Boerwinkle, Julie E. Buring, Laura Crisponi, Douglas F. Easton, Caroline Hayward, Frank B. Hu, Simin Liu, Andres Metspalu, Craig E. Pennell, Paul M. Ridker, Konstantin Strauch, Elizabeth A. Streeten, Daniela Toniolo, André G. Uitterlinden, Sheila Ulivi, Henry Völzke, Nicholas J. Wareham, Melissa Wellons, Nora Franceschini, Daniel I. Chasman, Unnur Thorsteinsdottir, Anna Murray, Kari Stefansson, Joanne M. Murabito, Ken K. Ong, John R. B. Perry Publié dans: Nature Communications, Numéro 20411723, 2015, Page(s) 7756, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms8756 In-solution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes Auteurs: M. Ivanov, M. Kals, M. Kacevska, A. Metspalu, M. Ingelman-Sundberg, L. Milani Publié dans: Nucleic Acids Research, Numéro 03051048, 2013, Page(s) e72-e72, ISSN 0305-1048 Éditeur: Oxford University Press DOI: 10.1093/nar/gks1467 DNA mismatch repair gene MSH6 implicated in determining age at natural menopause Auteurs: J. R. B. Perry, Y.-H. Hsu, D. I. Chasman, A. D. Johnson, C. Elks, E. Albrecht, I. L. Andrulis, J. Beesley, G. S. Berenson, S. Bergmann, S. E. Bojesen, M. K. Bolla, J. Brown, J. E. Buring, H. Campbell, J. Chang-Claude, G. Chenevix-Trench, T. Corre, F. J. Couch, A. Cox, K. Czene, A. P. D'adamo, G. Davies, I. J. Deary, J. Dennis, D. F. Easton, E. G. Engelhardt, J. G. Eriksson, T. Esko, P. A. Fasching, J. D. Figueroa, H. Flyger, A. Fraser, M. Garcia-Closas, P. Gasparini, C. Gieger, G. Giles, P. Guenel, S. Hagg, P. Hall, C. Hayward, J. Hopper, E. Ingelsson, S. L. R. Kardia, K. Kasiman, J. A. Knight, J. Lahti, D. A. Lawlor, P. K. E. Magnusson, S. Margolin, J. A. Marsh, A. Metspalu, J. E. Olson, C. E. Pennell, O. Polasek, I. Rahman, P. M. Ridker, A. Robino, I. Rudan, A. Rudolph, A. Salumets, M. K. Schmidt, M. J. Schoemaker, E. N. Smith, J. A. Smith, M. Southey, D. Stockl, A. J. Swerdlow, D. J. Thompson, T. Truong, S. Ulivi, M. Waldenberger, Q. Wang, S. Wild, J. F. Wilson, A. F. Wright, L. Zgaga, K. K. Ong, J. M. Murabito, D. Karasik, A. Murray Publié dans: Human Molecular Genetics, Numéro 09646906, 2014, Page(s) 2490-2497, ISSN 0964-6906 Éditeur: Oxford University Press DOI: 10.1093/hmg/ddt620 A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease Auteurs: Majid Nikpay, Anuj Goel, Hong-Hee Won, Leanne M Hall, Christina Willenborg, Stavroula Kanoni, Danish Saleheen, Theodosios Kyriakou, Christopher P Nelson, Jemma C Hopewell, Thomas R Webb, Lingyao Zeng, Abbas Dehghan, Maris Alver, Sebastian M Armasu, Kirsi Auro, Andrew Bjonnes, Daniel I Chasman, Shufeng Chen, Ian Ford, Nora Franceschini, Christian Gieger, Christopher Grace, Stefan Gustafsson, Jie Huang, Shih-Jen Hwang, Yun Kyoung Kim, Marcus E Kleber, King Wai Lau, Xiangfeng Lu, Yingchang Lu, Leo-Pekka Lyytikäinen, Evelin Mihailov, Alanna C Morrison, Natalia Pervjakova, Liming Qu, Lynda M Rose, Elias Salfati, Richa Saxena, Markus Scholz, Albert V Smith, Emmi Tikkanen, Andre Uitterlinden, Xueli Yang, Weihua Zhang, Wei Zhao, Mariza de Andrade, Paul S de Vries, Natalie R van Zuydam, Sonia S Anand, Lars Bertram, Frank Beutner, George Dedoussis, Philippe Frossard, Dominique Gauguier, Alison H Goodall, Omri Gottesman, Marc Haber, Bok-Ghee Han, Jianfeng Huang, Shapour Jalilzadeh, Thorsten Kessler, Inke R König, Lars Lannfelt, Wolfgang Lieb, Lars Lind, Cecilia M Lindgren, Marja-Liisa Lokki, Patrik K Magnusson, Nadeem H Mallick, Narinder Mehra, Thomas Meitinger, Fazal-ur-Rehman Memon, Andrew P Morris, Markku S Nieminen, Nancy L Pedersen, Annette Peters, Loukianos S Rallidis, Asif Rasheed, Maria Samuel, Svati H Shah, Juha Sinisalo, Kathleen E Stirrups, Stella Trompet, Laiyuan Wang, Khan S Zaman, Diego Ardissino, Eric Boerwinkle, Ingrid B Borecki, Erwin P Bottinger, Julie E Buring, John C Chambers, Rory Collins, L Adrienne Cupples, John Danesh, Ilja Demuth, Roberto Elosua, Stephen E Epstein, Tõnu Esko, Mary F Feitosa, Oscar H Franco, Maria Grazia Franzosi, Christopher B Granger, Dongfeng Gu, Vilmundur Gudnason, Alistair S Hall, Anders Hamsten, Tamara B Harris, Stanley L Hazen, Christian Hengstenberg, Albert Hofman, Erik Ingelsson, Carlos Iribarren, J Wouter Jukema, Pekka J Karhunen, Bong-Jo Kim, Jaspal S Kooner, Iftikhar J Kullo, Terho Lehtimäki, Ruth J F Loos, Olle Melander, Andres Metspalu, Winfried März, Colin N Palmer, Markus Perola, Thomas Quertermous, Daniel J Rader, Paul M Ridker, Samuli Ripatti, Robert Roberts, Veikko Salomaa, Dharambir K Sanghera, Stephen M Schwartz, Udo Seedorf, Alexandre F Stewart, David J Stott, Joachim Thiery, Pierre A Zalloua, Christopher J O'Donnell, Muredach P Reilly, Themistocles L Assimes, John R Thompson, Jeanette Erdmann, Robert Clarke, Hugh Watkins, Sekar Kathiresan, Ruth McPherson, Panos Deloukas, Heribert Schunkert, Nilesh J Samani, Martin Farrall Publié dans: Nature Genetics, Numéro 10614036, 2015, Page(s) 1121-1130, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3396 Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche Auteurs: John R. B. Perry, Felix Day, Cathy E. Elks, Patrick Sulem, Deborah J. Thompson, Teresa Ferreira, Chunyan He, Daniel I. Chasman, Tõnu Esko, Gudmar Thorleifsson, Eva Albrecht, Wei Q. Ang, Tanguy Corre, Diana L. Cousminer, Bjarke Feenstra, Nora Franceschini, Andrea Ganna, Andrew D. Johnson, Sanela Kjellqvist, Kathryn L. Lunetta, George McMahon, Ilja M. Nolte, Lavinia Paternoster, Eleonora Porcu, Albert V. Smith, Lisette Stolk, Alexander Teumer, Natalia Tšernikova, Emmi Tikkanen, Sheila Ulivi, Erin K. Wagner, Najaf Amin, Laura J. Bierut, Enda M. Byrne, Jouke-Jan Hottenga, Daniel L. Koller, Massimo Mangino, Tune H. Pers, Laura M. Yerges-Armstrong, Jing Hua Zhao, Irene L. Andrulis, Hoda Anton-Culver, Femke Atsma, Stefania Bandinelli, Matthias W. Beckmann, Javier Benitez, Carl Blomqvist, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Hiltrud Brauch, Hermann Brenner, Julie E. Buring, Jenny Chang-Claude, Stephen Chanock, Jinhui Chen, Georgia Chenevix-Trench, J. Margriet Collée, Fergus J. Couch, David Couper, Andrea D. Coviello, Angela Cox, Kamila Czene, Adamo Pio D’adamo, George Davey Smith, Immaculata De Vivo, Ellen W. Demerath, Joe Dennis, Peter Devilee, Aida K. Dieffenbach, Alison M. Dunning, Gudny Eiriksdottir, Johan G. Eriksson, Peter A. Fasching, Luigi Ferrucci, Dieter Flesch-Janys, Henrik Flyger, Tatiana Foroud, Lude Franke, Melissa E. Garcia, Montserrat García-Closas, Frank Geller, Eco E. J. de Geus, Graham G. Giles, Daniel F. Gudbjartsson, Vilmundur Gudnason, Pascal Guénel, Suiqun Guo, Per Hall, Ute Hamann, Robin Haring, Catharina A. Hartman, Andrew C. Heath, Albert Hofman, Maartje J. Hooning, John L. Hopper, Frank B. Hu, David J. Hunter, David Karasik, Douglas P. Kiel, Julia A. Knight, Veli-Matti Kosma, Zoltan Kutalik, Sandra Lai, Diether Lambrechts, Annika Lindblom, Reedik Mägi, Patrik K. Magnusson, Arto Mannermaa, Nicholas G. Martin, Gisli Masson, Patrick F. McArdle, Wendy L. McArdle, Mads Melbye, Kyriaki Michailidou, Evelin Mihailov, Lili Milani, Roger L. Milne, Heli Nevanlinna, Patrick Neven, Ellen A. Nohr, Albertine J. Oldehinkel, Ben A. Oostra, Aarno Palotie, Munro Peacock, Nancy L. Pedersen, Paolo Peterlongo, Julian Peto, Paul D. P. Pharoah, Dirkje S. Postma, Anneli Pouta, Katri Pylkäs, Paolo Radice, Susan Ring, Fernando Rivadeneira, Antonietta Robino, Lynda M. Rose, Anja Rudolph, Veikko Salomaa, Serena Sanna, David Schlessinger, Marjanka K. Schmidt, Mellissa C. Southey, Ulla Sovio, Meir J. Stampfer, Doris Stöckl, Anna M. Storniolo, Nicholas J. Timpson, Jonathan Tyrer, Jenny A. Visser, Peter Vollenweider, Henry Völzke, Gerard Waeber, Melanie Waldenberger, Henri Wallaschofski, Qin Wang, Gonneke Willemsen, Robert Winqvist, Bruce H. R. Wolffenbuttel, Margaret J. Wright, Dorret I. Boomsma, Michael J. Econs, Kay-Tee Khaw, Ruth J. F. Loos, Mark I. McCarthy, Grant W. Montgomery, John P. Rice, Elizabeth A. Streeten, Unnur Thorsteinsdottir, Cornelia M. van Duijn, Behrooz Z. Alizadeh, Sven Bergmann, Eric Boerwinkle, Heather A. Boyd, Laura Crisponi, Paolo Gasparini, Christian Gieger, Tamara B. Harris, Erik Ingelsson, Marjo-Riitta Järvelin, Peter Kraft, Debbie Lawlor, Andres Metspalu, Craig E. Pennell, Paul M. Ridker, Harold Snieder, Thorkild I. A. Sørensen, Tim D. Spector, David P. Strachan, André G. Uitterlinden, Nicholas J. Wareham, Elisabeth Widen, Marek Zygmunt, Anna Murray, Douglas F. Easton, Kari Stefansson, Joanne M. Murabito, Ken K. Ong Publié dans: Nature, Numéro 00280836, 2014, Page(s) 92-97, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature13545 A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension Auteurs: Tianxiao Huan, Tõnu Esko, Marjolein J. Peters, Luke C. Pilling, Katharina Schramm, Claudia Schurmann, Brian H. Chen, Chunyu Liu, Roby Joehanes, Andrew D. Johnson, Chen Yao, Sai-xia Ying, Paul Courchesne, Lili Milani, Nalini Raghavachari, Richard Wang, Poching Liu, Eva Reinmaa, Abbas Dehghan, Albert Hofman, André G. Uitterlinden, Dena G. Hernandez, Stefania Bandinelli, Andrew Singleton, David Melzer, Andres Metspalu, Maren Carstensen, Harald Grallert, Christian Herder, Thomas Meitinger, Annette Peters, Michael Roden, Melanie Waldenberger, Marcus Dörr, Stephan B. Felix, Tanja Zeller, Ramachandran Vasan, Christopher J. O'Donnell, Peter J. Munson, Xia Yang, Holger Prokisch, Uwe Völker, Joyce B. J. van Meurs, Luigi Ferrucci, Daniel Levy Publié dans: PLOS Genetics, Numéro 15537404, 2015, Page(s) e1005035, ISSN 1553-7404 Éditeur: PLOS DOI: 10.1371/journal.pgen.1005035 Biological interpretation of genome-wide association studies using predicted gene functions Auteurs: Tune H. Pers, Juha M. Karjalainen, Yingleong Chan, Harm-Jan Westra, Andrew R. Wood, Jian Yang, Julian C. Lui, Sailaja Vedantam, Stefan Gustafsson, Tonu Esko, Tim Frayling, Elizabeth K. Speliotes, Michael Boehnke, Soumya Raychaudhuri, Rudolf S. N. Fehrmann, Joel N. Hirschhorn, Lude Franke Publié dans: Nature Communications, Numéro 20411723, 2015, Page(s) 5890, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms6890 Coffin–Siris Syndrome with obesity, macrocephaly, hepatomegaly and hyperinsulinism caused by a mutation in the ARID1B gene Auteurs: Mari-Anne Vals, Eve Õiglane-Shlik, Margit Nõukas, Riina Shor, Aleksandr Peet, Mart Kals, Paula Ann Kivistik, Andres Metspalu, Katrin Õunap Publié dans: European Journal of Human Genetics, Numéro 10184813, 2014, Page(s) 1327-1329, ISSN 1018-4813 Éditeur: Natue Publishing Group DOI: 10.1038/ejhg.2014.25 Non-syndromic Tooth Agenesis Associated with a Nonsense Mutation in Ectodysplasin-A (EDA) Auteurs: T. Nikopensius, T. Annilo, T. Jagomagi, C. Gilissen, M. Kals, K. Krjutskov, R. Magi, M. Eelmets, U. Gerst-Talas, M. Remm, M. Saag, A. Hoischen, A. Metspalu Publié dans: Journal of Dental Research, Numéro 00220345, 2013, Page(s) 507-511, ISSN 0022-0345 Éditeur: SAGE Publications DOI: 10.1177/0022034513487210 The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects Auteurs: W J Peyrot, S H Lee, Y Milaneschi, A Abdellaoui, E M Byrne, T Esko, E J C de Geus, G Hemani, J J Hottenga, S Kloiber, D F Levinson, S Lucae, C M Lewis, S P Hamilton, M M Weissman, G Breen, D H Blackwood, S Cichon, A C Heath, F Holsboer, P A Madden, P McGuffin, P Muglia, M L Pergadia, D Lin, B Müller-Myhsok, S Steinberg, H J Grabe, P Lichtenstein, P Magnusson, R H Perlis, M Preisig, J W Smoller, K Stefansson, R Uher, Z Kutalik, K E Tansey, A Teumer, A Viktorin, M R Barnes, T Bettecken, E B Binder, R Breuer, V M Castro, S E Churchill, W H Coryell, N Craddock, I W Craig, D Czamara, F Degenhardt, A E Farmer, M Fava, J Frank, V S Gainer, P J Gallagher, S D Gordon, S Goryachev, M Gross, M Guipponi, A K Henders, S Herms, I B Hickie, S Hoefels, W Hoogendijk, D V Iosifescu, M Ising, I Jones, L Jones, T Jung-Ying, J A Knowles, I S Kohane, M A Kohli, A Korszun, M Landen, W B Lawson, G Lewis, D Macintyre, W Maier, M Mattheisen, P J McGrath, A McIntosh, A McLean, C M Middeldorp, L Middleton, G M Montgomery, S N Murphy, M Nauck, W A Nolen, D R Nyholt, M O'Donovan, H Oskarsson, N Pedersen, W A Scheftner, A Schulz, T G Schulze, S I Shyn, E Sigurdsson, S L Slager, J H Smit, H Stefansson, M Steffens, T Thorgeirsson, F Tozzi, J Treutlein, M Uhr, E J van den Oord, G Van Grootheest, H Völzke, J B Weilburg, G Willemsen, F G Zitman, B Neale, M Daly, P F Sullivan, N G Martin, S E Medland, A Metspalu, L Milani, M M Noethen, J B Potash, M Rietschel, C A Rietveld, S Ripke, J Shi, Arpana Agrawal, Eva Albrecht, Behrooz Z Alizadeh, Jüri Allik, Najaf Amin, John R Attia, Stefania Bandinelli, John Barnard, François Bastardot, Sebastian E Baumeister, Jonathan Beauchamp, Daniel J Benjamin, Kelly S Benke, David A Bennett, Klaus Berger, Lawrence F Bielak, Laura J Bierut, Jeffrey A Boatman, Patricia A Boyle, Ute Bültmann, Harry Campbell, David Cesarini, Christopher F Chabris, Lynn Cherkas, Mina K Chung, Dalton Conley, Francesco Cucca, George Davey-Smith, Gail Davies, Mariza de Andrade, Philip L De Jager, Christiaan de Leeuw, Jan-Emmanuel De Neve, Ian J Deary, George V Dedoussis, Panos Deloukas, Jaime Derringer, Maria Dimitriou, Gudny Eiriksdottir, Niina Eklund, Martin F Elderson, Johan G Eriksson, Daniel S Evans, David M Evans, Jessica D Faul, Rudolf Fehrmann, Luigi Ferrucci, Krista Fischer, Lude Franke, Melissa E Garcia, Christian Gieger, Håkon K Gjessing, Patrick J F Groenen, Henrik Grönberg, Vilmundur Gudnason, Sara Hägg, Per Hall, Jennifer R Harris, Juliette M Harris, Tamara B Harris, Nicholas D Hastie, Caroline Hayward, Andrew C Heath, Dena G Hernandez, Wolgang Hoffmann, Adriaan Hofman, Albert Hofman, Rolf Holle, Elizabeth G Holliday, Christina Holzapfel, William G Iacono, Carla A Ibrahim-Verbaas, Thomas Illig, Erik Ingelsson, Bo Jacobsson, Marjo-Riitta Järvelin, Min A Jhun, Magnus Johannesson, Peter K Joshi, Astanand Jugessur, Marika Kaakinen, Mika Kähönen, Stavroula Kanoni, Jaakkko Kaprio, Sharon L R Kardia, Juha Karjalainen, Robert M Kirkpatrick, Philipp D Koellinger, Ivana Kolcic, Matthew Kowgier, Kati Kristiansson, Robert F Krueger, Zóltan Kutalik, Jari Lahti, David Laibson, Antti Latvala, Lenore J Launer, Debbie A Lawlor, Terho Lethimäki, Jingmei Li, Paul Lichtenstein, Peter K Lichtner, David C Liewald, Peng Lin, Penelope A Lind, Yongmei Liu, Kurt Lohman, Marisa Loitfelder, Pamela A Madden, Patrick K E Magnusson, Tomi E Mäkinen, Pedro Marques Vidal, Nicolas W Martin, Marco Masala, Matt McGue, George McMahon, Osorio Meirelles, Michelle N Meyer, Andreas Mielck, Lili Milani, Michael B Miller, Grant W Montgomery, Sutapa Mukherjee, Ronny Myhre, Marja-Liisa Nuotio, Dale R Nyholt, Christopher J Oldmeadow, Ben A Oostra, Lyle J Palmer, Aarno Palotie, Markus Perola, Katja E Petrovic, Patricia A Peyser, Ozren Polašek, Danielle Posthuma, Martin Preisig, Lydia Quaye, Katri Räikkönen, Olli T Raitakari, Anu Realo, Eva Reinmaa, John P Rice, Susan M Ring, Samuli Ripatti, Fernando Rivadeneira, Thais S Rizzi, Igor Rudan, Aldo Rustichini, Veikko Salomaa, A Publié dans: Molecular Psychiatry, Numéro 13594184, 2015, Page(s) 735-743, ISSN 1359-4184 Éditeur: Nature Publishing Group DOI: 10.1038/mp.2015.50 Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory Auteurs: Stéphanie M. van den Berg, Marleen H. M. de Moor, Matt McGue, Erik Pettersson, Antonio Terracciano, Karin J. H. Verweij, Najaf Amin, Jaime Derringer, Tõnu Esko, Gerard van Grootheest, Narelle K. Hansell, Jennifer Huffman, Bettina Konte, Jari Lahti, Michelle Luciano, Lindsay K. Matteson, Alexander Viktorin, Jasper Wouda, Arpana Agrawal, Jüri Allik, Laura Bierut, Ulla Broms, Harry Campbell, George Davey Smith, Johan G. Eriksson, Luigi Ferrucci, Barbera Franke, Jean-Paul Fox, Eco J. C. de Geus, Ina Giegling, Alan J. Gow, Richard Grucza, Annette M. Hartmann, Andrew C. Heath, Kauko Heikkilä, William G. Iacono, Joost Janzing, Markus Jokela, Lambertus Kiemeney, Terho Lehtimäki, Pamela A. F. Madden, Patrik K. E. Magnusson, Kate Northstone, Teresa Nutile, Klaasjan G. Ouwens, Aarno Palotie, Alison Pattie, Anu-Katriina Pesonen, Ozren Polasek, Lea Pulkkinen, Laura Pulkki-Råback, Olli T. Raitakari, Anu Realo, Richard J. Rose, Daniela Ruggiero, Ilkka Seppälä, Wendy S. Slutske, David C. Smyth, Rossella Sorice, John M. Starr, Angelina R. Sutin, Toshiko Tanaka, Josine Verhagen, Sita Vermeulen, Eero Vuoksimaa, Elisabeth Widen, Gonneke Willemsen, Margaret J. Wright, Lina Zgaga, Dan Rujescu, Andres Metspalu, James F. Wilson, Marina Ciullo, Caroline Hayward, Igor Rudan, Ian J. Deary, Katri Räikkönen, Alejandro Arias Vasquez, Paul T. Costa, Liisa Keltikangas-Järvinen, Cornelia M. van Duijn, Brenda W. J. H. Penninx, Robert F. Krueger, David M. Evans, Jaakko Kaprio, Nancy L. Pedersen, Nicholas G. Martin, Dorret I. Boomsma Publié dans: Behavior Genetics, Numéro 00018244, 2014, Page(s) 295-313, ISSN 0001-8244 Éditeur: Kluwer Academic Publishers DOI: 10.1007/s10519-014-9654-x Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels Auteurs: Harmen H. M. Draisma, René Pool, Michael Kobl, Rick Jansen, Ann-Kristin Petersen, Anika A. M. Vaarhorst, Idil Yet, Toomas Haller, Ayşe Demirkan, Tõnu Esko, Gu Zhu, Stefan Böhringer, Marian Beekman, Jan Bert van Klinken, Werner Römisch-Margl, Cornelia Prehn, Jerzy Adamski, Anton J. M. de Craen, Elisabeth M. van Leeuwen, Najaf Amin, Harish Dharuri, Harm-Jan Westra, Lude Franke, Eco J. C. de Geus, Jouke Jan Hottenga, Gonneke Willemsen, Anjali K. Henders, Grant W. Montgomery, Dale R. Nyholt, John B. Whitfield, Brenda W. Penninx, Tim D. Spector, Andres Metspalu, P. Eline Slagboom, Ko Willems van Dijk, Peter A. C. ‘t Hoen, Konstantin Strauch, Nicholas G. Martin, Gert-Jan B. van Ommen, Thomas Illig, Jordana T. Bell, Massimo Mangino, Karsten Suhre, Mark I. McCarthy, Christian Gieger, Aaron Isaacs, Cornelia M. van Duijn, Dorret I. Boomsma Publié dans: Nature Communications, Numéro 20411723, 2015, Page(s) 7208, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms8208 CDH13 promoter SNPs with pleiotropic effect on cardiometabolic parameters represent methylation QTLs Auteurs: Margus Putku, Mart Kals, Rain Inno, Silva Kasela, Elin Org, Viktor Kožich, Lili Milani, Maris Laan Publié dans: Human Genetics, Numéro 03406717, 2015, Page(s) 291-303, ISSN 0340-6717 Éditeur: Springer Verlag DOI: 10.1007/s00439-014-1521-6 Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course Auteurs: M. Graff, J. S. Ngwa, T. Workalemahu, G. Homuth, S. Schipf, A. Teumer, H. Volzke, H. Wallaschofski, G. R. Abecasis, L. Edward, C. Francesco, S. Sanna, P. Scheet, D. Schlessinger, C. Sidore, X. Xiao, Z. Wang, S. J. Chanock, K. B. Jacobs, R. B. Hayes, F. Hu, R. M. Van Dam, R. J. Crout, M. L. Marazita, J. R. Shaffer, L. D. Atwood, C. S. Fox, N. L. Heard-Costa, C. White, A. C. Choh, S. A. Czerwinski, E. W. Demerath, T. D. Dyer, B. Towne, N. Amin, B. A. Oostra, C. M. Van Duijn, M. C. Zillikens, T. Esko, M. Nelis, T. Nikopensius, A. Metspalu, D. P. Strachan, K. Monda, L. Qi, K. E. North, L. A. Cupples, P. Gordon-Larsen, S. I. Berndt Publié dans: Human Molecular Genetics, Numéro 09646906, 2013, Page(s) 3597-3607, ISSN 0964-6906 Éditeur: Oxford University Press DOI: 10.1093/hmg/ddt205 The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis Auteurs: Tove Fall, Sara Hägg, Reedik Mägi, Alexander Ploner, Krista Fischer, Momoko Horikoshi, Antti-Pekka Sarin, Gudmar Thorleifsson, Claes Ladenvall, Mart Kals, Maris Kuningas, Harmen H. M. Draisma, Janina S. Ried, Natalie R. van Zuydam, Ville Huikari, Massimo Mangino, Emily Sonestedt, Beben Benyamin, Christopher P. Nelson, Natalia V. Rivera, Kati Kristiansson, Huei-yi Shen, Aki S. Havulinna, Abbas Dehghan, Louise A. Donnelly, Marika Kaakinen, Marja-Liisa Nuotio, Neil Robertson, Renée F. A. G. de Bruijn, M. Arfan Ikram, Najaf Amin, Anthony J. Balmforth, Peter S. Braund, Alexander S. F. Doney, Angela Döring, Paul Elliott, Tõnu Esko, Oscar H. Franco, Solveig Gretarsdottir, Anna-Liisa Hartikainen, Kauko Heikkilä, Karl-Heinz Herzig, Hilma Holm, Jouke Jan Hottenga, Elina Hyppönen, Thomas Illig, Aaron Isaacs, Bo Isomaa, Lennart C. Karssen, Johannes Kettunen, Wolfgang Koenig, Kari Kuulasmaa, Tiina Laatikainen, Jaana Laitinen, Cecilia Lindgren, Valeriya Lyssenko, Esa Läärä, Nigel W. Rayner, Satu Männistö, Anneli Pouta, Wolfgang Rathmann, Fernando Rivadeneira, Aimo Ruokonen, Markku J. Savolainen, Eric J. G. Sijbrands, Kerrin S. Small, Jan H. Smit, Valgerdur Steinthorsdottir, Ann-Christine Syvänen, Anja Taanila, Martin D. Tobin, Andre G. Uitterlinden, Sara M. Willems, Gonneke Willemsen, Jacqueline Witteman, Markus Perola, Alun Evans, Jean Ferrières, Jarmo Virtamo, Frank Kee, David-Alexandre Tregouet, Dominique Arveiler, Philippe Amouyel, Marco M. Ferrario, Paolo Brambilla, Alistair S. Hall, Andrew C. Heath, Pamela A. F. Madden, Nicholas G. Martin, Grant W. Montgomery, John B. Whitfield, Antti Jula, Paul Knekt, Ben Oostra, Cornelia M. van Duijn, Brenda W. J. H. Penninx, George Davey Smith, Jaakko Kaprio, Nilesh J. Samani, Christian Gieger, Annette Peters, H.-Erich Wichmann, Dorret I. Boomsma, Eco J. C. de Geus, TiinaMaija Tuomi, Chris Power, Christopher J. Hammond, Tim D. Spector, Lars Lind, Marju Orho-Melander, Colin Neil Alexander Palmer, Andrew D. Morris, Leif Groop, Marjo-Riitta Järvelin, Veikko Salomaa, Erkki Vartiainen, Albert Hofman, Samuli Ripatti, Andres Metspalu, Unnur Thorsteinsdottir, Kari Stefansson, Nancy L. Pedersen, Mark I. McCarthy, Erik Ingelsson, Inga Prokopenko Publié dans: PLoS Medicine, Numéro 15491676, 2013, Page(s) e1001474, ISSN 1549-1676 Éditeur: PLOS DOI: 10.1371/journal.pmed.1001474 Defining the role of common variation in the genomic and biological architecture of adult human height Auteurs: Andrew R Wood, Tonu Esko, Jian Yang, Sailaja Vedantam, Tune H Pers, Stefan Gustafsson, Audrey Y Chu, Karol Estrada, Jian'an Luan, Zoltán Kutalik, Najaf Amin, Martin L Buchkovich, Damien C Croteau-Chonka, Felix R Day, Yanan Duan, Tove Fall, Rudolf Fehrmann, Teresa Ferreira, Anne U Jackson, Juha Karjalainen, Ken Sin Lo, Adam E Locke, Reedik Mägi, Evelin Mihailov, Eleonora Porcu, Joshua C Randall, André Scherag, Anna A E Vinkhuyzen, Harm-Jan Westra, Thomas W Winkler, Tsegaselassie Workalemahu, Jing Hua Zhao, Devin Absher, Eva Albrecht, Denise Anderson, Jeffrey Baron, Marian Beekman, Ayse Demirkan, Georg B Ehret, Bjarke Feenstra, Mary F Feitosa, Krista Fischer, Ross M Fraser, Anuj Goel, Jian Gong, Anne E Justice, Stavroula Kanoni, Marcus E Kleber, Kati Kristiansson, Unhee Lim, Vaneet Lotay, Julian C Lui, Massimo Mangino, Irene Mateo Leach, Carolina Medina-Gomez, Michael A Nalls, Dale R Nyholt, Cameron D Palmer, Dorota Pasko, Sonali Pechlivanis, Inga Prokopenko, Janina S Ried, Stephan Ripke, Dmitry Shungin, Alena Stancáková, Rona J Strawbridge, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sander W van der Laan, Jessica van Setten, Jana V Van Vliet-Ostaptchouk, Zhaoming Wang, Loïc Yengo, Weihua Zhang, Uzma Afzal, Johan Ärnlöv, Gillian M Arscott, Stefania Bandinelli, Amy Barrett, Claire Bellis, Amanda J Bennett, Christian Berne, Matthias Blüher, Jennifer L Bolton, Yvonne Böttcher, Heather A Boyd, Marcel Bruinenberg, Brendan M Buckley, Steven Buyske, Ida H Caspersen, Peter S Chines, Robert Clarke, Simone Claudi-Boehm, Matthew Cooper, E Warwick Daw, Pim A De Jong, Joris Deelen, Graciela Delgado, Josh C Denny, Rosalie Dhonukshe-Rutten, Maria Dimitriou, Alex S F Doney, Marcus Dörr, Niina Eklund, Elodie Eury, Lasse Folkersen, Melissa E Garcia, Frank Geller, Vilmantas Giedraitis, Alan S Go, Harald Grallert, Tanja B Grammer, Jürgen Gräßler, Henrik Grönberg, Lisette C P G M de Groot, Christopher J Groves, Jeffrey Haessler, Per Hall, Toomas Haller, Goran Hallmans, Anke Hannemann, Catharina A Hartman, Maija Hassinen, Caroline Hayward, Nancy L Heard-Costa, Quinta Helmer, Gibran Hemani, Anjali K Henders, Hans L Hillege, Mark A Hlatky, Wolfgang Hoffmann, Per Hoffmann, Oddgeir Holmen, Jeanine J Houwing-Duistermaat, Thomas Illig, Aaron Isaacs, Alan L James, Janina Jeff, Berit Johansen, Åsa Johansson, Jennifer Jolley, Thorhildur Juliusdottir, Juhani Junttila, Abel N Kho, Leena Kinnunen, Norman Klopp, Thomas Kocher, Wolfgang Kratzer, Peter Lichtner, Lars Lind, Jaana Lindström, Stéphane Lobbens, Mattias Lorentzon, Yingchang Lu, Valeriya Lyssenko, Patrik K E Magnusson, Anubha Mahajan, Marc Maillard, Wendy L McArdle, Colin A McKenzie, Stela McLachlan, Paul J McLaren, Cristina Menni, Sigrun Merger, Lili Milani, Alireza Moayyeri, Keri L Monda, Mario A Morken, Gabriele Müller, Martina Müller-Nurasyid, Arthur W Musk, Narisu Narisu, Matthias Nauck, Ilja M Nolte, Markus M Nöthen, Laticia Oozageer, Stefan Pilz, Nigel W Rayner, Frida Renstrom, Neil R Robertson, Lynda M Rose, Ronan Roussel, Serena Sanna, Hubert Scharnagl, Salome Scholtens, Fredrick R Schumacher, Heribert Schunkert, Robert A Scott, Joban Sehmi, Thomas Seufferlein, Jianxin Shi, Karri Silventoinen, Johannes H Smit, Albert Vernon Smith, Joanna Smolonska, Alice V Stanton, Kathleen Stirrups, David J Stott, Heather M Stringham, Johan Sundström, Morris A Swertz, Ann-Christine Syvänen, Bamidele O Tayo, Gudmar Thorleifsson, Jonathan P Tyrer, Suzanne van Dijk, Natasja M van Schoor, Nathalie van der Velde, Diana van Heemst, Floor V A van Oort, Sita H Vermeulen, Niek Verweij, Judith M Vonk, Lindsay L Waite, Melanie Waldenberger, Roman Wennauer, Lynne R Wilkens, Christina Willenborg, Tom Wilsgaard, Mary K Wojczynski, Andrew Wong, Alan F Wright, Qunyuan Zhang, Dominique Arveiler, Stephan J L Bakker, John Beilby, Richard N Bergman, Sven Bergmann, Reiner Biffar, John Blangero, Dorret I Boomsma, Stefan R Bornstein, Pascal Bovet, Paolo Brambilla, Morris J Brown, Harry Campb Publié dans: Nature Genetics, Numéro 10614036, 2014, Page(s) 1173-1186, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3097 Copy Number Variations and Cognitive Phenotypes in Unselected Populations Auteurs: Katrin Männik, Reedik Mägi, Aurélien Macé, Ben Cole, Anna L. Guyatt, Hashem A. Shihab, Anne M. Maillard, Helene Alavere, Anneli Kolk, Anu Reigo, Evelin Mihailov, Liis Leitsalu, Anne-Maud Ferreira, Margit Nõukas, Alexander Teumer, Erika Salvi, Daniele Cusi, Matt McGue, William G. Iacono, Tom R. Gaunt, Jacques S. Beckmann, Sébastien Jacquemont, Zoltán Kutalik, Nathan Pankratz, Nicholas Timpson, Andres Metspalu, Alexandre Reymond Publié dans: JAMA, Numéro 00987484, 2015, Page(s) 2044, ISSN 0098-7484 Éditeur: American Medical Association DOI: 10.1001/jama.2015.4845 Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity Auteurs: Sara Hägg, Andrea Ganna, Sander W. Van Der Laan, Tonu Esko, Tune H. Pers, Adam E. Locke, Sonja I. Berndt, Anne E. Justice, Bratati Kahali, Marten A. Siemelink, Gerard Pasterkamp, David P. Strachan, Elizabeth K. Speliotes, Kari E. North, Ruth J.F. Loos, Joel N. Hirschhorn, Yudi Pawitan, Erik Ingelsson Publié dans: Human Molecular Genetics, Numéro 09646906, 2015, Page(s) 6849-6860, ISSN 0964-6906 Éditeur: Oxford University Press DOI: 10.1093/hmg/ddv379 Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: The ARCAGE study Auteurs: Wolfgang Ahrens, Hermann Pohlabeln, Ronja Foraita, Mari Nelis, Pagona Lagiou, Areti Lagiou, Christine Bouchardy, Alena Slamova, Miriam Schejbalova, Franco Merletti, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsague, Tatiana V. Macfarlane, Gary J. Macfarlane, Yuan-Chin Amy Lee, Renato Talamini, Luigi Barzan, Cristina Canova, Lorenzo Simonato, Peter Thomson, Patricia A. McKinney, Alex D. McMahon, Ariana Znaor, Claire M. Healy, Bernad E. McCartan, Andres Metspalu, Manuela Marron, Mia Hashibe, David I. Conway, Paul Brennan Publié dans: Oral Oncology, Numéro 13688375, 2014, Page(s) 616-625, ISSN 1368-8375 Éditeur: Pergamon Press Ltd. DOI: 10.1016/j.oraloncology.2014.03.001 From pharmacogenetics to pharmacometabolomics: SAM modulates TPMT activity Auteurs: Nataša Karas-Kuželički, Alenka Šmid, Riin Tamm, Andres Metspalu, Irena Mlinarič-Raščan Publié dans: Pharmacogenomics, Numéro 14622416, 2014, Page(s) 1437-1449, ISSN 1462-2416 Éditeur: Ashley Publications Ltd. DOI: 10.2217/pgs.14.84 Extensive alterations of the whole-blood transcriptome are associated with body mass index: results of an mRNA profiling study involving two large population-based cohorts Auteurs: Georg Homuth, Simone Wahl, Christian Müller, Claudia Schurmann, Ulrike Mäder, Stefan Blankenberg, Maren Carstensen, Marcus Dörr, Karlhans Endlich, Christian Englbrecht, Stephan B. Felix, Christian Gieger, Harald Grallert, Christian Herder, Thomas Illig, Jochen Kruppa, Carola S. Marzi, Julia Mayerle, Thomas Meitinger, Andres Metspalu, Matthias Nauck, Annette Peters, Wolfgang Rathmann, Eva Reinmaa, Rainer Rettig, Michael Roden, Arne Schillert, Katharina Schramm, Leif Steil, Konstantin Strauch, Alexander Teumer, Henry Völzke, Henri Wallaschofski, Philipp S. Wild, Andreas Ziegler, Uwe Völker, Holger Prokisch, Tanja Zeller Publié dans: BMC Medical Genomics, Numéro 17558794, 2015, ISSN 1755-8794 Éditeur: BioMed Central DOI: 10.1186/s12920-015-0141-x Linking a Population Biobank with National Health Registries—The Estonian Experience Auteurs: Liis Leitsalu, Helene Alavere, Mari-Liis Tammesoo, Erkki Leego, Andres Metspalu Publié dans: Journal of Personalized Medicine, Numéro 20754426, 2015, Page(s) 96-106, ISSN 2075-4426 Éditeur: MDPI AG DOI: 10.3390/jpm5020096 Identification of seven loci affecting mean telomere length and their association with disease Auteurs: Veryan Codd, Christopher P Nelson, Eva Albrecht, Massimo Mangino, Joris Deelen, Jessica L Buxton, Jouke Jan Hottenga, Krista Fischer, Tõnu Esko, Ida Surakka, Linda Broer, Dale R Nyholt, Irene Mateo Leach, Perttu Salo, Sara Hägg, Mary K Matthews, Jutta Palmen, Giuseppe D Norata, Paul F O'Reilly, Danish Saleheen, Najaf Amin, Anthony J Balmforth, Marian Beekman, Rudolf A de Boer, Stefan Böhringer, Peter S Braund, Paul R Burton, Anton J Mde Craen, Matthew Denniff, Yanbin Dong, Konstantinos Douroudis, Elena Dubinina, Johan G Eriksson, Katia Garlaschelli, Dehuang Guo, Anna-Liisa Hartikainen, Anjali K Henders, Jeanine J Houwing-Duistermaat, Laura Kananen, Lennart C Karssen, Johannes Kettunen, Norman Klopp, Vasiliki Lagou, Elisabeth M van Leeuwen, Pamela A Madden, Reedik Mägi, Patrik K E Magnusson, Satu Männistö, Mark I McCarthy, Sarah E Medland, Evelin Mihailov, Grant W Montgomery, Ben A Oostra, Aarno Palotie, Annette Peters, Helen Pollard, Anneli Pouta, Inga Prokopenko, Samuli Ripatti, Veikko Salomaa, H Eka D Suchiman, Ana M Valdes, Niek Verweij, Ana Viñuela, Xiaoling Wang, H-Erich Wichmann, Elisabeth Widen, Gonneke Willemsen, Margaret J Wright, Kai Xia, Xiangjun Xiao, Dirk J van Veldhuisen, Alberico L Catapano, Martin D Tobin, Alistair S Hall, Alexandra I F Blakemore, Wiek H van Gilst, Haidong Zhu, CARDIoGRAM consortium, Jeanette Erdmann, Muredach P Reilly, Sekar Kathiresan, Heribert Schunkert, Philippa J Talmud, Nancy L Pedersen, Markus Perola, Willem Ouwehand, Jaakko Kaprio, Nicholas G Martin, Cornelia M van Duijn, Iiris Hovatta, Christian Gieger, Andres Metspalu, Dorret I Boomsma, Marjo-Riitta Jarvelin, P Eline Slagboom, John R Thompson, Tim D Spector, Pim van der Harst, Nilesh J Samani Publié dans: Nature Genetics, Numéro 10614036, 2013, Page(s) 422-427, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.2528 Population genetic differentiation of height and body mass index across Europe Auteurs: Matthew R Robinson, Gibran Hemani, Carolina Medina-Gomez, Massimo Mezzavilla, Tonu Esko, Konstantin Shakhbazov, Joseph E Powell, Anna Vinkhuyzen, Sonja I Berndt, Stefan Gustafsson, Anne E Justice, Bratati Kahali, Adam E Locke, Tune H Pers, Sailaja Vedantam, Andrew R Wood, Wouter van Rheenen, Ole A Andreassen, Paolo Gasparini, Andres Metspalu, Leonard H van den Berg, Jan H Veldink, Fernando Rivadeneira, Thomas M Werge, Goncalo R Abecasis, Dorret I Boomsma, Daniel I Chasman, Eco J C de Geus, Timothy M Frayling, Joel N Hirschhorn, Jouke Jan Hottenga, Erik Ingelsson, Ruth J F Loos, Patrik K E Magnusson, Nicholas G Martin, Grant W Montgomery, Kari E North, Nancy L Pedersen, Timothy D Spector, Elizabeth K Speliotes, Michael E Goddard, Jian Yang, Peter M Visscher Publié dans: Nature Genetics, Numéro 10614036, 2015, Page(s) 1357-1362, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3401 Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans Auteurs: Jennifer E. Huffman, Eva Albrecht, Alexander Teumer, Massimo Mangino, Karen Kapur, Toby Johnson, Zoltán Kutalik, Nicola Pirastu, Giorgio Pistis, Lorna M. Lopez, Toomas Haller, Perttu Salo, Anuj Goel, Man Li, Toshiko Tanaka, Abbas Dehghan, Daniela Ruggiero, Giovanni Malerba, Albert V. Smith, Ilja M. Nolte, Laura Portas, Amanda Phipps-Green, Lora Boteva, Pau Navarro, Asa Johansson, Andrew A. Hicks, Ozren Polasek, Tõnu Esko, John F. Peden, Sarah E. Harris, Federico Murgia, Sarah H. Wild, Albert Tenesa, Adrienne Tin, Evelin Mihailov, Anne Grotevendt, Gauti K. Gislason, Josef Coresh, Pio D'Adamo, Sheila Ulivi, Peter Vollenweider, Gerard Waeber, Susan Campbell, Ivana Kolcic, Krista Fisher, Margus Viigimaa, Jeffrey E. Metter, Corrado Masciullo, Elisabetta Trabetti, Cristina Bombieri, Rossella Sorice, Angela Döring, Eva Reischl, Konstantin Strauch, Albert Hofman, Andre G. Uitterlinden, Melanie Waldenberger, H-Erich Wichmann, Gail Davies, Alan J. Gow, Nicola Dalbeth, Lisa Stamp, Johannes H. Smit, Mirna Kirin, Ramaiah Nagaraja, Matthias Nauck, Claudia Schurmann, Kathrin Budde, Susan M. Farrington, Evropi Theodoratou, Antti Jula, Veikko Salomaa, Cinzia Sala, Christian Hengstenberg, Michel Burnier, Reedik Mägi, Norman Klopp, Stefan Kloiber, Sabine Schipf, Samuli Ripatti, Stefano Cabras, Nicole Soranzo, Georg Homuth, Teresa Nutile, Patricia B. Munroe, Nicholas Hastie, Harry Campbell, Igor Rudan, Claudia Cabrera, Chris Haley, Oscar H. Franco, Tony R. Merriman, Vilmundur Gudnason, Mario Pirastu, Brenda W. Penninx, Harold Snieder, Andres Metspalu, Marina Ciullo, Peter P. Pramstaller, Cornelia M. van Duijn, Luigi Ferrucci, Giovanni Gambaro, Ian J. Deary, Malcolm G. Dunlop, James F. Wilson, Paolo Gasparini, Ulf Gyllensten, Tim D. Spector, Alan F. Wright, Caroline Hayward, Hugh Watkins, Markus Perola, Murielle Bochud, W. H. Linda Kao, Mark Caulfield, Daniela Toniolo, Henry Völzke, Christian Gieger, Anna Köttgen, Veronique Vitart Publié dans: PLOS ONE, Numéro 19326203, 2015, Page(s) e0119752, ISSN 1932-6203 Éditeur: Public Library of Science DOI: 10.1371/journal.pone.0119752 Copper Metabolism Domain-Containing 1 Represses Genes That Promote Inflammation and Protects Mice From Colitis and Colitis-Associated Cancer Auteurs: Haiying Li, Lillienne Chan, Paulina Bartuzi, Shelby D. Melton, Axel Weber, Shani Ben–Shlomo, Chen Varol, Megan Raetz, Xicheng Mao, Petro Starokadomskyy, Suzanne van Sommeren, Mohamad Mokadem, Heike Schneider, Reid Weisberg, Harm-Jan Westra, Tõnu Esko, Andres Metspalu, Vinod Kumar, William A. Faubion, Felix Yarovinsky, Marten Hofker, Cisca Wijmenga, Michael Kracht, Lude Franke, Vincent Aguirre, Rinse K. Weersma, Nathan Gluck, Bart van de Sluis, Ezra Burstein Publié dans: Gastroenterology, Numéro 00165085, 2014, Page(s) 184-195.e3, ISSN 0016-5085 Éditeur: W. B. Saunders Co., Ltd. DOI: 10.1053/j.gastro.2014.04.007 BBMRI-ERIC as a resource for pharmaceutical and life science industries: the development of biobank-based Expert Centres Auteurs: Gert-Jan B van Ommen, Outi Törnwall, Christian Bréchot, Georges Dagher, Joakim Galli, Kristian Hveem, Ulf Landegren, Claudio Luchinat, Andres Metspalu, Cecilia Nilsson, Ove V Solesvik, Markus Perola, Jan-Eric Litton, Kurt Zatloukal Publié dans: European Journal of Human Genetics, Numéro 10184813, 2014, Page(s) 893-900, ISSN 1018-4813 Éditeur: Natue Publishing Group DOI: 10.1038/ejhg.2014.235 Cumulative Small Effect Genetic Markers and the Risk of Colorectal Cancer in Poland, Estonia, Lithuania, and Latvia Auteurs: Pablo Serrano-Fernandez, Dagmara Dymerska, Grzegorz Kurzawski, Róża Derkacz, Tatiana Sobieszczańska, Zbigniew Banaszkiewicz, Hanno Roomere, Eneli Oitmaa, Andres Metspalu, Ramūnas Janavičius, Pavel Elsakov, Mindaugas Razumas, Kestutis Petrulis, Arvīds Irmejs, Edvīns Miklaševičs, Rodney J. Scott, Jan Lubiński Publié dans: Gastroenterology Research and Practice, Numéro 16876121, 2015, Page(s) 1-10, ISSN 1687-6121 Éditeur: Hindawi Publishing Corporation DOI: 10.1155/2015/204089 Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function Auteurs: Maxim Ivanov, Mart Kals, Marina Kacevska, Isabel Barragan, Kie Kasuga, Anders Rane, Andres Metspalu, Lili Milani, Magnus Ingelman-Sundberg Publié dans: Genome Biology, Numéro 14656906, 2013, Page(s) R83, ISSN 1465-6906 Éditeur: BioMed Central DOI: 10.1186/gb-2013-14-8-r83 Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression Auteurs: Vinod Kumar, Harm-Jan Westra, Juha Karjalainen, Daria V. Zhernakova, Tõnu Esko, Barbara Hrdlickova, Rodrigo Almeida, Alexandra Zhernakova, Eva Reinmaa, Urmo Võsa, Marten H. Hofker, Rudolf S. N. Fehrmann, Jingyuan Fu, Sebo Withoff, Andres Metspalu, Lude Franke, Cisca Wijmenga Publié dans: PLoS Genetics, Numéro 15537404, 2013, Page(s) e1003201, ISSN 1553-7404 Éditeur: PLOS DOI: 10.1371/journal.pgen.1003201 Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent Auteurs: L. Fernandez-Rhodes, E. W. Demerath, D. L. Cousminer, R. Tao, J. G. Dreyfus, T. Esko, A. V. Smith, V. Gudnason, T. B. Harris, L. Launer, P. F. McArdle, L. M. Yerges-Armstrong, C. E. Elks, D. P. Strachan, Z. Kutalik, P. Vollenweider, B. Feenstra, H. A. Boyd, A. Metspalu, E. Mihailov, L. Broer, M. C. Zillikens, B. Oostra, C. M. van Duijn, K. L. Lunetta, J. R. B. Perry, A. Murray, D. L. Koller, D. Lai, T. Corre, D. Toniolo, E. Albrecht, D. Stockl, H. Grallert, C. Gieger, C. Hayward, O. Polasek, I. Rudan, J. F. Wilson, C. He, P. Kraft, F. B. Hu, D. J. Hunter, J.-J. Hottenga, G. Willemsen, D. I. Boomsma, E. M. Byrne, N. G. Martin, G. W. Montgomery, N. M. Warrington, C. E. Pennell, L. Stolk, J. A. Visser, A. Hofman, A. G. Uitterlinden, F. Rivadeneira, P. Lin, S. L. Fisher, L. J. Bierut, L. Crisponi, E. Porcu, M. Mangino, G. Zhai, T. D. Spector, J. E. Buring, L. M. Rose, P. M. Ridker, C. Poole, J. N. Hirschhorn, J. M. Murabito, D. I. Chasman, E. Widen, K. E. North, K. K. Ong, N. Franceschini Publié dans: American Journal of Epidemiology, Numéro 00029262, 2013, Page(s) 451-460, ISSN 0002-9262 Éditeur: Oxford University Press DOI: 10.1093/aje/kws473 Can selenium levels act as a marker of colorectal cancer risk? Auteurs: Marcin R Lener, Satish Gupta, Rodney J Scott, Martin Tootsi, Maria Kulp, Mari-Liis Tammesoo, Anu Viitak, Anders Metspalu, Pablo Serrano-Fernández, Józef Kładny, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Magdalena Muszyńska, Grzegorz Sukiennicki, Anna Jakubowska, Jan Lubiński Publié dans: BMC Cancer, Numéro 14712407, 2013, Page(s) 214, ISSN 1471-2407 Éditeur: BioMed Central DOI: 10.1186/1471-2407-13-214 The relationship between the Five-Factor Model personality traits and peptic ulcer disease in a large population-based adult sample Auteurs: Anu Realo, Andero Teras, Liisi Kööts-Ausmees, Tõnu Esko, Andres Metspalu, Jüri Allik Publié dans: Scandinavian Journal of Psychology, Numéro 00365564, 2015, Page(s) 693-699, ISSN 0036-5564 Éditeur: Blackwell Publishing Inc. DOI: 10.1111/sjop.12248 Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia Auteurs: Darren R. Brenner, Christopher I. Amos, Yonathan Brhane, Maria N. Timofeeva, Neil Caporaso, Yufei Wang, David C. Christiani, Heike Bickeböller, Ping Yang, Demetrius Albanes, Victoria L. Stevens, Susan Gapstur, James McKay, Paolo Boffetta, David Zaridze, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Hans E. Krokan, Frank Skorpen, Maiken E. Gabrielsen, Lars Vatten, Inger Njølstad, Chu Chen, Gary Goodman, Mark Lathrop, Tõnu Vooder, Kristjan Välk, Mari Nelis, Andres Metspalu, Peter Broderick, Timothy Eisen, Xifeng Wu, Di Zhang, Wei Chen, Margaret R. Spitz, Yongyue Wei, Li Su, Dong Xie, Jun She, Keitaro Matsuo, Fumihiko Matsuda, Hidemi Ito, Angela Risch, Joachim Heinrich, Albert Rosenberger, Thomas Muley, Hendrik Dienemann, John K. Field, Olaide Raji, Ying Chen, John Gosney, Triantafillos Liloglou, Michael P.A. Davies, Michael Marcus, John McLaughlin, Irene Orlow, Younghun Han, Yafang Li, Xuchen Zong, Mattias Johansson, Geoffrey Liu, Shelley S. Tworoger, Loic Le Marchand, Brian E. Henderson, Lynne R. Wilkens, Juncheng Dai, Hongbing Shen, Richard S. Houlston, Maria T. Landi, Paul Brennan, Rayjean J. Hung Publié dans: Carcinogenesis, Numéro 01433334, 2015, Page(s) 1314-1326, ISSN 0143-3334 Éditeur: Oxford University Press DOI: 10.1093/carcin/bgv128 Genetic variants of inducible costimulator are associated with allergic asthma susceptibility Auteurs: Anand Kumar Andiappan, Sriram Narayanan, Rachel A. Myers, Bernett Lee, Maartje A. Nieuwenhuis, Alessandra Nardin, Choon-Sik Park, Hyoung Doo Shin, Jeong-Hyun Kim, Harm-Jan Westra, Lude Franke, Tonu Esko, Andres Metspalu, Yik-Ying Teo, Seang Mei Saw, Chiea Chuen Khor, Jianjun Liu, Gerard H. Koppelman, Dirkje S. Postma, Michael Poidinger, John E. Connolly, De Yun Wang, Olaf Rotzschke, Maria A. Curotto de Lafaille, Fook Tim Chew Publié dans: Journal of Allergy and Clinical Immunology, Numéro 00916749, 2015, Page(s) 556-558.e13, ISSN 0091-6749 Éditeur: Mosby Inc. DOI: 10.1016/j.jaci.2014.06.028 Tissue-specific mitochondrial heteroplasmy at position 16,093 within the same individual Auteurs: Kaarel Krjutškov, Marina Koltšina, Kelli Grand, Urmo Võsa, Martin Sauk, Neeme Tõnisson, Andres Salumets Publié dans: Current Genetics, Numéro 01728083, 2014, Page(s) 11-16, ISSN 0172-8083 Éditeur: Springer Verlag DOI: 10.1007/s00294-013-0398-6 Directional dominance on stature and cognition in diverse human populations Auteurs: Peter K. Joshi, Tonu Esko, Hannele Mattsson, Niina Eklund, Ilaria Gandin, Teresa Nutile, Anne U. Jackson, Claudia Schurmann, Albert V. Smith, Weihua Zhang, Yukinori Okada, Alena Stančáková, Jessica D. Faul, Wei Zhao, Traci M. Bartz, Maria Pina Concas, Nora Franceschini, Stefan Enroth, Veronique Vitart, Stella Trompet, Xiuqing Guo, Daniel I. Chasman, Jeffrey R. O'Connel, Tanguy Corre, Suraj S. Nongmaithem, Yuning Chen, Massimo Mangino, Daniela Ruggiero, Michela Traglia, Aliki-Eleni Farmaki, Tim Kacprowski, Andrew Bjonnes, Ashley van der Spek, Ying Wu, Anil K. Giri, Lisa R. Yanek, Lihua Wang, Edith Hofer, Cornelius A. Rietveld, Olga McLeod, Marilyn C. Cornelis, Cristian Pattaro, Niek Verweij, Clemens Baumbach, Abdel Abdellaoui, Helen R. Warren, Dragana Vuckovic, Hao Mei, Claude Bouchard, John R. B. Perry, Stefania Cappellani, Saira S. Mirza, Miles C. Benton, Ulrich Broeckel, Sarah E. Medland, Penelope A. Lind, Giovanni Malerba, Alexander Drong, Loic Yengo, Lawrence F. Bielak, Degui Zhi, Peter J. van der Most, Daniel Shriner, Reedik Mägi, Gibran Hemani, Tugce Karaderi, Zhaoming Wang, Tian Liu, Ilja Demuth, Jing Hua Zhao, Weihua Meng, Lazaros Lataniotis, Sander W. van der Laan, Jonathan P. Bradfield, Andrew R. Wood, Amelie Bonnefond, Tarunveer S. Ahluwalia, Leanne M. Hall, Erika Salvi, Seyhan Yazar, Lisbeth Carstensen, Hugoline G. de Haan, Mark Abney, Uzma Afzal, Matthew A. Allison, Najaf Amin, Folkert W. Asselbergs, Stephan J. L. Bakker, R. Graham Barr, Sebastian E. Baumeister, Daniel J. Benjamin, Sven Bergmann, Eric Boerwinkle, Erwin P. Bottinger, Archie Campbell, Aravinda Chakravarti, Yingleong Chan, Stephen J. Chanock, Constance Chen, Y.-D. Ida Chen, Francis S. Collins, John Connell, Adolfo Correa, L. Adrienne Cupples, George Davey Smith, Gail Davies, Marcus Dörr, Georg Ehret, Stephen B. Ellis, Bjarke Feenstra, Mary F. Feitosa, Ian Ford, Caroline S. Fox, Timothy M. Frayling, Nele Friedrich, Frank Geller, Generation Scotland, Irina Gillham-Nasenya, Omri Gottesman, Misa Graff, Francine Grodstein, Charles Gu, Chris Haley, Christopher J. Hammond, Sarah E. Harris, Tamara B. Harris, Nicholas D. Hastie, Nancy L. Heard-Costa, Kauko Heikkilä, Lynne J. Hocking, Georg Homuth, Jouke-Jan Hottenga, Jinyan Huang, Jennifer E. Huffman, Pirro G. Hysi, M. Arfan Ikram, Erik Ingelsson, Anni Joensuu, Åsa Johansson, Pekka Jousilahti, J. Wouter Jukema, Mika Kähönen, Yoichiro Kamatani, Stavroula Kanoni, Shona M. Kerr, Nazir M. Khan, Philipp Koellinger, Heikki A. Koistinen, Manraj K. Kooner, Michiaki Kubo, Johanna Kuusisto, Jari Lahti, Lenore J. Launer, Rodney A. Lea, Benjamin Lehne, Terho Lehtimäki, David C.M. Liewald, Lars Lind, Marie Loh, Marja-Liisa Lokki, Stephanie J. London, Stephanie J. Loomis, Anu Loukola, Yingchang Lu, Thomas Lumley, Annamari Lundqvist, Satu Männistö, Pedro Marques-Vidal, Corrado Masciullo, Angela Matchan, Rasika A. Mathias, Koichi Matsuda, James B. Meigs, Christa Meisinger, Thomas Meitinger, Cristina Menni, Frank D. Mentch, Evelin Mihailov, Lili Milani, May E. Montasser, Grant W. Montgomery, Alanna Morrison, Richard H. Myers, Rajiv Nadukuru, Pau Navarro, Mari Nelis, Markku S. Nieminen, Ilja M. Nolte, George T. O'Connor, Adesola Ogunniyi, Sandosh Padmanabhan, Walter R. Palmas, James S. Pankow, Inga Patarcic, Francesca Pavani, Patricia A. Peyser, Kirsi Pietilainen, Neil Poulter, Inga Prokopenko, Sarju Ralhan, Paul Redmond, Stephen S. Rich, Harri Rissanen, Antonietta Robino, Lynda M. Rose, Richard Rose, Cinzia Sala, Babatunde Salako, Veikko Salomaa, Antti-Pekka Sarin, Richa Saxena, Helena Schmidt, Laura J. Scott, William R. Scott, Bengt Sennblad, Sudha Seshadri, Peter Sever, Smeeta Shrestha, Blair H. Smith, Jennifer A. Smith, Nicole Soranzo, Nona Sotoodehnia, Lorraine Southam, Alice V. Stanton, Maria G. Stathopoulou, Konstantin Strauch, Rona J. Strawbridge, Matthew J. Suderman, Nikhil Tandon, Sian-Tsun Tang, Kent D. Taylor, Bamidele O. Tayo, Anna Maria Töglhofer, Maciej Tomaszewski, Natalia Tšernikova, Jaakko Tuomi Publié dans: Nature, Numéro 00280836, 2015, Page(s) 459-462, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature14618 Mediation Analysis Demonstrates That Trans-eQTLs Are Often Explained by Cis-Mediation: A Genome-Wide Analysis among 1,800 South Asians Auteurs: Brandon L. Pierce, Lin Tong, Lin S. Chen, Ronald Rahaman, Maria Argos, Farzana Jasmine, Shantanu Roy, Rachelle Paul-Brutus, Harm-Jan Westra, Lude Franke, Tonu Esko, Rakibuz Zaman, Tariqul Islam, Mahfuzar Rahman, John A. Baron, Muhammad G. Kibriya, Habibul Ahsan Publié dans: PLoS Genetics, Numéro 15537404, 2014, Page(s) e1004818, ISSN 1553-7404 Éditeur: PLOS DOI: 10.1371/journal.pgen.1004818 Complementary seminovaginal microbiome in couples Auteurs: Reet Mändar, Margus Punab, Natalja Borovkova, Eleri Lapp, Riinu Kiiker, Paul Korrovits, Andres Metspalu, Kaarel Krjutškov, Hiie Nõlvak, Jens-Konrad Preem, Kristjan Oopkaup, Andres Salumets, Jaak Truu Publié dans: Research in Microbiology, Numéro 09232508, 2015, Page(s) 440-447, ISSN 0923-2508 Éditeur: Elsevier BV DOI: 10.1016/j.resmic.2015.03.009 A Genome-Wide Analysis of Populations from European Russia Reveals a New Pole of Genetic Diversity in Northern Europe Auteurs: Andrey V. Khrunin, Denis V. Khokhrin, Irina N. Filippova, Tõnu Esko, Mari Nelis, Natalia A. Bebyakova, Natalia L. Bolotova, Janis Klovins, Liene Nikitina-Zake, Karola Rehnström, Samuli Ripatti, Stefan Schreiber, Andre Franke, Milan Macek, Veronika Krulišová, Jan Lubinski, Andres Metspalu, Svetlana A. Limborska Publié dans: PLoS ONE, Numéro 19326203, 2013, Page(s) e58552, ISSN 1932-6203 Éditeur: Public Library of Science DOI: 10.1371/journal.pone.0058552 Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis Auteurs: Beben Benyamin, Tonu Esko, Janina S. Ried, Aparna Radhakrishnan, Sita H. Vermeulen, Michela Traglia, Martin Gögele, Denise Anderson, Linda Broer, Clara Podmore, Jian’an Luan, Zoltan Kutalik, Serena Sanna, Peter van der Meer, Toshiko Tanaka, Fudi Wang, Harm-Jan Westra, Lude Franke, Evelin Mihailov, Lili Milani, Jonas Häldin, Juliane Winkelmann, Thomas Meitinger, Joachim Thiery, Annette Peters, Melanie Waldenberger, Augusto Rendon, Jennifer Jolley, Jennifer Sambrook, Lambertus A. Kiemeney, Fred C. Sweep, Cinzia F. Sala, Christine Schwienbacher, Irene Pichler, Jennie Hui, Ayse Demirkan, Aaron Isaacs, Najaf Amin, Maristella Steri, Gérard Waeber, Niek Verweij, Joseph E. Powell, Dale R. Nyholt, Andrew C. Heath, Pamela A. F. Madden, Peter M. Visscher, Margaret J. Wright, Grant W. Montgomery, Nicholas G. Martin, Dena Hernandez, Stefania Bandinelli, Pim van der Harst, Manuela Uda, Peter Vollenweider, Robert A. Scott, Claudia Langenberg, Nicholas J. Wareham, Cornelia van Duijn, John Beilby, Peter P. Pramstaller, Andrew A. Hicks, Willem H. Ouwehand, Konrad Oexle, Christian Gieger, Andres Metspalu, Clara Camaschella, Daniela Toniolo, Dorine W. Swinkels, John B. Whitfield Publié dans: Nature Communications, Numéro 20411723, 2014, Page(s) 4926, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms5926 Functional Impact and Evolution of a Novel Human Polymorphic Inversion That Disrupts a Gene and Creates a Fusion Transcript Auteurs: Marta Puig, David Castellano, Lorena Pantano, Carla Giner-Delgado, David Izquierdo, Magdalena Gayà-Vidal, José Ignacio Lucas-Lledó, Tõnu Esko, Chikashi Terao, Fumihiko Matsuda, Mario Cáceres Publié dans: PLOS Genetics, Numéro 15537404, 2015, Page(s) e1005495, ISSN 1553-7404 Éditeur: Public Library of Science DOI: 10.1371/journal.pgen.1005495 A genome-wide association study of early menopause and the combined impact of identified variants Auteurs: J. R. B. Perry, T. Corre, T. Esko, D. I. Chasman, K. Fischer, N. Franceschini, C. He, Z. Kutalik, M. Mangino, L. M. Rose, A. Vernon Smith, L. Stolk, P. Sulem, M. N. Weedon, W. V. Zhuang, A. Arnold, A. Ashworth, S. Bergmann, J. E. Buring, A. Burri, C. Chen, M. C. Cornelis, D. J. Couper, M. O. Goodarzi, V. Gudnason, T. Harris, A. Hofman, M. Jones, P. Kraft, L. Launer, J. S. E. Laven, G. Li, B. McKnight, C. Masciullo, L. Milani, N. Orr, B. M. Psaty, P. M. Ridker, F. Rivadeneira, C. Sala, A. Salumets, M. Schoemaker, M. Traglia, G. Waeber, S. J. Chanock, E. W. Demerath, M. Garcia, S. E. Hankinson, F. B. Hu, D. J. Hunter, K. L. Lunetta, A. Metspalu, G. W. Montgomery, J. M. Murabito, A. B. Newman, K. K. Ong, T. D. Spector, K. Stefansson, A. J. Swerdlow, U. Thorsteinsdottir, R. M. Van Dam, A. G. Uitterlinden, J. A. Visser, P. Vollenweider, D. Toniolo, A. Murray Publié dans: Human Molecular Genetics, Numéro 09646906, 2013, Page(s) 1465-1472, ISSN 0964-6906 Éditeur: Oxford University Press DOI: 10.1093/hmg/dds551 Allowing for non-adherence to treatment in a randomized controlled trial of two antidepressants (citalopram versus reboxetine): an example from the GENPOD trial Auteurs: N. J. Wiles, K. Fischer, P. Cowen, D. Nutt, T. J. Peters, G. Lewis, I. R. White Publié dans: Psychological Medicine, Numéro 00332917, 2014, Page(s) 2855-2866, ISSN 0033-2917 Éditeur: Cambridge University Press DOI: 10.1017/S0033291714000221 Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies Auteurs: Cristina Rodriguez-Fontenla, Manuel Calaza, Evangelos Evangelou, Ana M. Valdes, Nigel Arden, Francisco J. Blanco, Andrew Carr, Kay Chapman, Panos Deloukas, Michael Doherty, Tõnu Esko, Carlos M. Garcés Aletá, Juan J. Gomez-Reino Carnota, Hafdis Helgadottir, Albert Hofman, Ingileif Jonsdottir, Hanneke J. M. Kerkhof, Margreet Kloppenburg, Andrew McCaskie, Evangelia E. Ntzani, William E. R. Ollier, Natividad Oreiro, Kalliope Panoutsopoulou, Stuart H. Ralston, Yolande F. Ramos, Jose A. Riancho, Fernando Rivadeneira, P. Eline Slagboom, Unnur Styrkarsdottir, Unnur Thorsteinsdottir, Gudmar Thorleifsson, Aspasia Tsezou, André G. Uitterlinden, Gillian A. Wallis, J. Mark Wilkinson, Guangju Zhai, Yanyan Zhu, David T. Felson, John P. A. Ioannidis, John Loughlin, Andres Metspalu, Ingrid Meulenbelt, Kari Stefansson, Joyce B. van Meurs, Eleftheria Zeggini, Timothy D. Spector, Antonio Gonzalez Publié dans: Arthritis & Rheumatology, Numéro 23265191, 2014, Page(s) 940-949, ISSN 2326-5191 Éditeur: Wiley DOI: 10.1002/art.38300 Mapping the Genetic Architecture of Gene Regulation in Whole Blood Auteurs: Katharina Schramm, Carola Marzi, Claudia Schurmann, Maren Carstensen, Eva Reinmaa, Reiner Biffar, Gertrud Eckstein, Christian Gieger, Hans-Jörgen Grabe, Georg Homuth, Gabriele Kastenmüller, Reedik Mägi, Andres Metspalu, Evelin Mihailov, Annette Peters, Astrid Petersmann, Michael Roden, Konstantin Strauch, Karsten Suhre, Alexander Teumer, Uwe Völker, Henry Völzke, Rui Wang-Sattler, Melanie Waldenberger, Thomas Meitinger, Thomas Illig, Christian Herder, Harald Grallert, Holger Prokisch Publié dans: PLoS ONE, Numéro 19326203, 2014, Page(s) e93844, ISSN 1932-6203 Éditeur: Public Library of Science DOI: 10.1371/journal.pone.0093844 Global implementation of genomic medicine: We are not alone Auteurs: T. A. Manolio, M. Abramowicz, F. Al-Mulla, W. Anderson, R. Balling, A. C. Berger, S. Bleyl, A. Chakravarti, W. Chantratita, R. L. Chisholm, V. H. W. Dissanayake, M. Dunn, V. J. Dzau, B.-G. Han, T. Hubbard, A. Kolbe, B. Korf, M. Kubo, P. Lasko, E. Leego, S. Mahasirimongkol, P. P. Majumdar, G. Matthijs, H. L. McLeod, A. Metspalu, P. Meulien, S. Miyano, Y. Naparstek, P. P. O'Rourke, G. P. Patrinos, H. L. Rehm, M. V. Relling, G. Rennert, L. L. Rodriguez, D. M. Roden, A. R. Shuldiner, S. Sinha, P. Tan, M. Ulfendahl, R. Ward, M. S. Williams, J. E. L. Wong, E. D. Green, G. S. Ginsburg Publié dans: Science Translational Medicine, Numéro 19466234, 2015, Page(s) 290ps13-290ps13, ISSN 1946-6234 Éditeur: American Association for the Advancement of Science DOI: 10.1126/scitranslmed.aab0194 Common genetic variants associated with cognitive performance identified using the proxy-phenotype method Auteurs: C. A. Rietveld, T. Esko, G. Davies, T. H. Pers, P. Turley, B. Benyamin, C. F. Chabris, V. Emilsson, A. D. Johnson, J. J. Lee, C. d. Leeuw, R. E. Marioni, S. E. Medland, M. B. Miller, O. Rostapshova, S. J. van der Lee, A. A. E. Vinkhuyzen, N. Amin, D. Conley, J. Derringer, C. M. van Duijn, R. Fehrmann, L. Franke, E. L. Glaeser, N. K. Hansell, C. Hayward, W. G. Iacono, C. Ibrahim-Verbaas, V. Jaddoe, J. Karjalainen, D. Laibson, P. Lichtenstein, D. C. Liewald, P. K. E. Magnusson, N. G. Martin, M. McGue, G. McMahon, N. L. Pedersen, S. Pinker, D. J. Porteous, D. Posthuma, F. Rivadeneira, B. H. Smith, J. M. Starr, H. Tiemeier, N. J. Timpson, M. Trzaskowski, A. G. Uitterlinden, F. C. Verhulst, M. E. Ward, M. J. Wright, G. Davey Smith, I. J. Deary, M. Johannesson, R. Plomin, P. M. Visscher, D. J. Benjamin, D. Cesarini, P. D. Koellinger Publié dans: Proceedings of the National Academy of Sciences, Numéro 00278424, 2014, Page(s) 13790-13794, ISSN 0027-8424 Éditeur: National Academy of Sciences DOI: 10.1073/pnas.1404623111 Genetic and epigenetic regulation of gene expression in fetal and adult human livers Auteurs: Marc Bonder, Silva Kasela, Mart Kals, Riin Tamm, Kaie Lokk, Isabel Barragan, Wim A Buurman, Patrick Deelen, Jan-Willem Greve, Maxim Ivanov, Sander S Rensen, Jana V van Vliet-Ostaptchouk, Marcel G Wolfs, Jingyuan Fu, Marten H Hofker, Cisca Wijmenga, Alexandra Zhernakova, Magnus Ingelman-Sundberg, Lude Franke, Lili Milani Publié dans: BMC Genomics, Numéro 14712164, 2014, Page(s) 860, ISSN 1471-2164 Éditeur: BioMed Central DOI: 10.1186/1471-2164-15-860 Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu Auteurs: Liis Leitsalu, Toomas Haller, Tõnu Esko, Mari-Liis Tammesoo, Helene Alavere, Harold Snieder, Markus Perola, Pauline C Ng, Reedik Mägi, Lili Milani, Krista Fischer, Andres Metspalu Publié dans: International Journal of Epidemiology, Numéro 03005771, 2015, Page(s) 1137-1147, ISSN 0300-5771 Éditeur: Oxford University Press DOI: 10.1093/ije/dyt268 Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation Auteurs: Norihiro Kato, Marie Loh, Fumihiko Takeuchi, Niek Verweij, Xu Wang, Weihua Zhang, Tanika N Kelly, Danish Saleheen, Benjamin Lehne, Irene Mateo Leach, Alexander W Drong, James Abbott, Simone Wahl, Sian-Tsung Tan, William R Scott, Gianluca Campanella, Marc Chadeau-Hyam, Uzma Afzal, Tarunveer S Ahluwalia, Marc Jan Bonder, Peng Chen, Abbas Dehghan, Todd L Edwards, Tõnu Esko, Min Jin Go, Sarah E Harris, Jaana Hartiala, Silva Kasela, Anuradhani Kasturiratne, Chiea-Chuen Khor, Marcus E Kleber, Huaixing Li, Zuan Yu Mok, Masahiro Nakatochi, Nur Sabrina Sapari, Richa Saxena, Alexandre F R Stewart, Lisette Stolk, Yasuharu Tabara, Ai Ling Teh, Ying Wu, Jer-Yuarn Wu, Yi Zhang, Imke Aits, Alexessander Da Silva Couto Alves, Shikta Das, Rajkumar Dorajoo, Jemma C Hopewell, Yun Kyoung Kim, Robert W Koivula, Jian'an Luan, Leo-Pekka Lyytikäinen, Quang N Nguyen, Mark A Pereira, Iris Postmus, Olli T Raitakari, Molly Scannell Bryan, Robert A Scott, Rossella Sorice, Vinicius Tragante, Michela Traglia, Jon White, Ken Yamamoto, Yonghong Zhang, Linda S Adair, Alauddin Ahmed, Koichi Akiyama, Rasheed Asif, Tin Aung, Inês Barroso, Andrew Bjonnes, Timothy R Braun, Hui Cai, Li-Ching Chang, Chien-Hsiun Chen, Ching-Yu Cheng, Yap-Seng Chong, Rory Collins, Regina Courtney, Gail Davies, Graciela Delgado, Loi D Do, Pieter A Doevendans, Ron T Gansevoort, Yu-Tang Gao, Tanja B Grammer, Niels Grarup, Jagvir Grewal, Dongfeng Gu, Gurpreet S Wander, Anna-Liisa Hartikainen, Stanley L Hazen, Jing He, Chew-Kiat Heng, James E Hixson, Albert Hofman, Chris Hsu, Wei Huang, Lise L N Husemoen, Joo-Yeon Hwang, Sahoko Ichihara, Michiya Igase, Masato Isono, Johanne M Justesen, Tomohiro Katsuya, Muhammad G Kibriya, Young Jin Kim, Miyako Kishimoto, Woon-Puay Koh, Katsuhiko Kohara, Meena Kumari, Kenneth Kwek, Nanette R Lee, Jeannette Lee, Jiemin Liao, Wolfgang Lieb, David C M Liewald, Tatsuaki Matsubara, Yumi Matsushita, Thomas Meitinger, Evelin Mihailov, Lili Milani, Rebecca Mills, Nina Mononen, Martina Müller-Nurasyid, Toru Nabika, Eitaro Nakashima, Hong Kiat Ng, Kjell Nikus, Teresa Nutile, Takayoshi Ohkubo, Keizo Ohnaka, Sarah Parish, Lavinia Paternoster, Hao Peng, Annette Peters, Son T Pham, Mohitha J Pinidiyapathirage, Mahfuzar Rahman, Hiromi Rakugi, Olov Rolandsson, Michelle Ann Rozario, Daniela Ruggiero, Cinzia F Sala, Ralhan Sarju, Kazuro Shimokawa, Harold Snieder, Thomas Sparsø, Wilko Spiering, John M Starr, David J Stott, Daniel O Stram, Takao Sugiyama, Silke Szymczak, W H Wilson Tang, Lin Tong, Stella Trompet, Väinö Turjanmaa, Hirotsugu Ueshima, André G Uitterlinden, Satoshi Umemura, Marja Vaarasmaki, Rob M van Dam, Wiek H van Gilst, Dirk J van Veldhuisen, Jorma S Viikari, Melanie Waldenberger, Yiqin Wang, Aili Wang, Rory Wilson, Tien-Yin Wong, Yong-Bing Xiang, Shuhei Yamaguchi, Xingwang Ye, Robin D Young, Terri L Young, Jian-Min Yuan, Xueya Zhou, Folkert W Asselbergs, Marina Ciullo, Robert Clarke, Panos Deloukas, Andre Franke, Paul W Franks, Steve Franks, Yechiel Friedlander, Myron D Gross, Zhirong Guo, Torben Hansen, Marjo-Riitta Jarvelin, Torben Jørgensen, J Wouter Jukema, Mika Kähönen, Hiroshi Kajio, Mika Kivimaki, Jong-Young Lee, Terho Lehtimäki, Allan Linneberg, Tetsuro Miki, Oluf Pedersen, Nilesh J Samani, Thorkild I A Sørensen, Ryoichi Takayanagi, Daniela Toniolo, Habibul Ahsan, Hooman Allayee, Yuan-Tsong Chen, John Danesh, Ian J Deary, Oscar H Franco, Lude Franke, Bastiaan T Heijman, Joanna D Holbrook, Aaron Isaacs, Bong-Jo Kim, Xu Lin, Jianjun Liu, Winfried März, Andres Metspalu, Karen L Mohlke, Dharambir K Sanghera, Xiao-Ou Shu, Joyce B J van Meurs, Eranga Vithana, Ananda R Wickremasinghe, Cisca Wijmenga, Bruce H W Wolffenbuttel, Mitsuhiro Yokota, Wei Zheng, Dingliang Zhu, Paolo Vineis, Soterios A Kyrtopoulos, Jos C S Kleinjans, Mark I McCarthy, Richie Soong, Christian Gieger, James Scott, Yik-Ying Teo, Jiang He, Paul Elliott, E Shyong Tai, Pim van der Harst, Jaspal S Kooner, John C Chambers Publié dans: Nature Genetics, Numéro 10614036, 2015, Page(s) 1282-1293, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3405 De Novo SCN8A Mutation Identified by Whole-Exome Sequencing in a Boy With Neonatal Epileptic Encephalopathy, Multiple Congenital Anomalies, and Movement Disorders Auteurs: U. Vaher, M. Noukas, T. Nikopensius, M. Kals, T. Annilo, M. Nelis, K. Ounap, T. Reimand, I. Talvik, P. Ilves, A. Piirsoo, E. Seppet, A. Metspalu, T. Talvik Publié dans: Journal of Child Neurology, Numéro 08830738, 2014, Page(s) NP202-NP206, ISSN 0883-0738 Éditeur: SAGE Publications DOI: 10.1177/0883073813511300 Whole-exome sequencing identifies de novo mutation in the COL1A1 gene to underlie the severe osteogenesis imperfecta Auteurs: Katre Maasalu, Tiit Nikopensius, Sulev Kõks, Margit Nõukas, Mart Kals, Ele Prans, Lidiia Zhytnik, Andres Metspalu, Aare Märtson Publié dans: Human Genomics, Numéro 14797364, 2015, ISSN 1479-7364 Éditeur: BioMed Central DOI: 10.1186/s40246-015-0028-0 Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder Auteurs: Marleen H. M. de Moor, Stéphanie M. van den Berg, Karin J. H. Verweij, Robert F. Krueger, Michelle Luciano, Alejandro Arias Vasquez, Lindsay K. Matteson, Jaime Derringer, Tõnu Esko, Najaf Amin, Scott D. Gordon, Narelle K. Hansell, Amy B. Hart, Ilkka Seppälä, Jennifer E. Huffman, Bettina Konte, Jari Lahti, Minyoung Lee, Mike Miller, Teresa Nutile, Toshiko Tanaka, Alexander Teumer, Alexander Viktorin, Juho Wedenoja, Goncalo R. Abecasis, Daniel E. Adkins, Arpana Agrawal, Jüri Allik, Katja Appel, Timothy B. Bigdeli, Fabio Busonero, Harry Campbell, Paul T. Costa, George Davey Smith, Gail Davies, Harriet de Wit, Jun Ding, Barbara E. Engelhardt, Johan G. Eriksson, Iryna O. Fedko, Luigi Ferrucci, Barbara Franke, Ina Giegling, Richard Grucza, Annette M. Hartmann, Andrew C. Heath, Kati Heinonen, Anjali K. Henders, Georg Homuth, Jouke-Jan Hottenga, William G. Iacono, Joost Janzing, Markus Jokela, Robert Karlsson, John P. Kemp, Matthew G. Kirkpatrick, Antti Latvala, Terho Lehtimäki, David C. Liewald, Pamela A. F. Madden, Chiara Magri, Patrik K. E. Magnusson, Jonathan Marten, Andrea Maschio, Sarah E. Medland, Evelin Mihailov, Yuri Milaneschi, Grant W. Montgomery, Matthias Nauck, Klaasjan G. Ouwens, Aarno Palotie, Erik Pettersson, Ozren Polasek, Yong Qian, Laura Pulkki-Råback, Olli T. Raitakari, Anu Realo, Richard J. Rose, Daniela Ruggiero, Carsten O. Schmidt, Wendy S. Slutske, Rossella Sorice, John M. Starr, Beate St Pourcain, Angelina R. Sutin, Nicholas J. Timpson, Holly Trochet, Sita Vermeulen, Eero Vuoksimaa, Elisabeth Widen, Jasper Wouda, Margaret J. Wright, Lina Zgaga, David Porteous, Alessandra Minelli, Abraham A. Palmer, Dan Rujescu, Marina Ciullo, Caroline Hayward, Igor Rudan, Andres Metspalu, Jaakko Kaprio, Ian J. Deary, Katri Räikkönen, James F. Wilson, Liisa Keltikangas-Järvinen, Laura J. Bierut, John M. Hettema, Hans J. Grabe, Cornelia M. van Duijn, David M. Evans, David Schlessinger, Nancy L. Pedersen, Antonio Terracciano, Matt McGue, Brenda W. J. H. Penninx, Nicholas G. Martin, Dorret I. Boomsma Publié dans: JAMA Psychiatry, Numéro 2168622X, 2015, Page(s) 642, ISSN 2168-622X Éditeur: American Medical Association DOI: 10.1001/jamapsychiatry.2015.0554 Biological insights from 108 schizophrenia-associated genetic loci Auteurs: Stephan Ripke, Benjamin M. Neale, Aiden Corvin, James T. R. Walters, Kai-How Farh, Peter A. Holmans, Phil Lee, Brendan Bulik-Sullivan, David A. Collier, Hailiang Huang, Tune H. Pers, Ingrid Agartz, Esben Agerbo, Margot Albus, Madeline Alexander, Farooq Amin, Silviu A. Bacanu, Martin Begemann, Richard A. Belliveau Jr, Judit Bene, Sarah E. Bergen, Elizabeth Bevilacqua, Tim B. Bigdeli, Donald W. Black, Richard Bruggeman, Nancy G. Buccola, Randy L. Buckner, William Byerley, Wiepke Cahn, Guiqing Cai, Dominique Campion, Rita M. Cantor, Vaughan J. Carr, Noa Carrera, Stanley V. Catts, Kimberly D. Chambert, Raymond C. K. Chan, Ronald Y. L. Chen, Eric Y. H. Chen, Wei Cheng, Eric F. C. Cheung, Siow Ann Chong, C. Robert Cloninger, David Cohen, Nadine Cohen, Paul Cormican, Nick Craddock, James J. Crowley, David Curtis, Michael Davidson, Kenneth L. Davis, Franziska Degenhardt, Jurgen Del Favero, Ditte Demontis, Dimitris Dikeos, Timothy Dinan, Srdjan Djurovic, Gary Donohoe, Elodie Drapeau, Jubao Duan, Frank Dudbridge, Naser Durmishi, Peter Eichhammer, Johan Eriksson, Valentina Escott-Price, Laurent Essioux, Ayman H. Fanous, Martilias S. Farrell, Josef Frank, Lude Franke, Robert Freedman, Nelson B. Freimer, Marion Friedl, Joseph I. Friedman, Menachem Fromer, Giulio Genovese, Lyudmila Georgieva, Ina Giegling, Paola Giusti-Rodríguez, Stephanie Godard, Jacqueline I. Goldstein, Vera Golimbet, Srihari Gopal, Jacob Gratten, Lieuwe de Haan, Christian Hammer, Marian L. Hamshere, Mark Hansen, Thomas Hansen, Vahram Haroutunian, Annette M. Hartmann, Frans A. Henskens, Stefan Herms, Joel N. Hirschhorn, Per Hoffmann, Andrea Hofman, Mads V. Hollegaard, David M. Hougaard, Masashi Ikeda, Inge Joa, Antonio Julià, René S. Kahn, Luba Kalaydjieva, Sena Karachanak-Yankova, Juha Karjalainen, David Kavanagh, Matthew C. Keller, James L. Kennedy, Andrey Khrunin, Yunjung Kim, Janis Klovins, James A. Knowles, Bettina Konte, Vaidutis Kucinskas, Zita Ausrele Kucinskiene, Hana Kuzelova-Ptackova, Anna K. Kähler, Claudine Laurent, Jimmy Lee Chee Keong, S. Hong Lee, Sophie E. Legge, Bernard Lerer, Miaoxin Li, Tao Li, Kung-Yee Liang, Jeffrey Lieberman, Svetlana Limborska, Carmel M. Loughland, Jan Lubinski, Jouko Lönnqvist, Milan Macek Jr, Patrik K. E. Magnusson, Brion S. Maher, Wolfgang Maier, Jacques Mallet, Sara Marsal, Manuel Mattheisen, Morten Mattingsdal, Robert W. McCarley, Colm McDonald, Andrew M. McIntosh, Sandra Meier, Carin J. Meijer, Bela Melegh, Ingrid Melle, Raquelle I. Mesholam-Gately, Andres Metspalu, Patricia T. Michie, Lili Milani, Vihra Milanova, Younes Mokrab, Derek W. Morris, Ole Mors, Kieran C. Murphy, Robin M. Murray, Inez Myin-Germeys, Bertram Müller-Myhsok, Mari Nelis, Igor Nenadic, Deborah A. Nertney, Gerald Nestadt, Kristin K. Nicodemus, Liene Nikitina-Zake, Laura Nisenbaum, Annelie Nordin, Eadbhard O’Callaghan, Colm O’Dushlaine, F. Anthony O’Neill, Sang-Yun Oh, Ann Olincy, Line Olsen, Jim Van Os, Psychosis Endophenotypes International Consortium, Christos Pantelis, George N. Papadimitriou, Sergi Papiol, Elena Parkhomenko, Michele T. Pato, Tiina Paunio, Milica Pejovic-Milovancevic, Diana O. Perkins, Olli Pietiläinen, Jonathan Pimm, Andrew J. Pocklington, John Powell, Alkes Price, Ann E. Pulver, Shaun M. Purcell, Digby Quested, Henrik B. Rasmussen, Abraham Reichenberg, Mark A. Reimers, Alexander L. Richards, Joshua L. Roffman, Panos Roussos, Douglas M. Ruderfer, Veikko Salomaa, Alan R. Sanders, Ulrich Schall, Christian R. Schubert, Thomas G. Schulze, Sibylle G. Schwab, Edward M. Scolnick, Rodney J. Scott, Larry J. Seidman, Jianxin Shi, Engilbert Sigurdsson, Teimuraz Silagadze, Jeremy M. Silverman, Kang Sim, Petr Slominsky, Jordan W. Smoller, Hon-Cheong So, ChrisC. A. Spencer, Eli A. Stahl, Hreinn Stefansson, Stacy Steinberg, Elisabeth Stogmann, Richard E. Straub, Eric Strengman, Jana Strohmaier, T. Scott Stroup, Mythily Subramaniam, Jaana Suvisaari, Dragan M. Svrakic, Jin P. Szatkiewicz, Erik Söderman, Srinivas Thirumalai, Draga Toncheva Publié dans: Nature, Numéro 00280836, 2014, Page(s) 421-427, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature13595 Occupational irritants and asthma: an Estonian cross-sectional study of 34 000 adults Auteurs: O. Dumas, E. Laurent, J. Bousquet, A. Metspalu, L. Milani, F. Kauffmann, N. Le Moual Publié dans: European Respiratory Journal, Numéro 09031936, 2014, Page(s) 647-656, ISSN 0903-1936 Éditeur: European Respiratory Society DOI: 10.1183/09031936.00172213 Improved treatment and prognosis after acute myocardial infarction in Estonia: cross-sectional study from a high risk country Auteurs: Aet Saar, Toomas Marandi, Tiia Ainla, Krista Fischer, Mai Blöndal, Jaan Eha Publié dans: BMC Cardiovascular Disorders, Numéro 14712261, 2015, ISSN 1471-2261 Éditeur: BioMed Central DOI: 10.1186/s12872-015-0129-7 Haplotype Phasing and Inheritance of Copy Number Variants in Nuclear Families Auteurs: Priit Palta, Lauris Kaplinski, Liina Nagirnaja, Andres Veidenberg, Märt Möls, Mari Nelis, Tõnu Esko, Andres Metspalu, Maris Laan, Maido Remm Publié dans: PLOS ONE, Numéro 19326203, 2015, Page(s) e0122713, ISSN 1932-6203 Éditeur: Public Library of Science DOI: 10.1371/journal.pone.0122713 Within-Trait Heterogeneity in Age Group Differences in Personality Domains and Facets: Implications for the Development and Coherence of Personality Traits Auteurs: René Mõttus, Anu Realo, Jüri Allik, Tõnu Esko, Andres Metspalu, Wendy Johnson Publié dans: PLOS ONE, Numéro 19326203, 2015, Page(s) e0119667, ISSN 1932-6203 Éditeur: Public Library of Science DOI: 10.1371/journal.pone.0119667 Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons Auteurs: Krista Fischer, Johannes Kettunen, Peter Würtz, Toomas Haller, Aki S. Havulinna, Antti J. Kangas, Pasi Soininen, Tõnu Esko, Mari-Liis Tammesoo, Reedik Mägi, Steven Smit, Aarno Palotie, Samuli Ripatti, Veikko Salomaa, Mika Ala-Korpela, Markus Perola, Andres Metspalu Publié dans: PLoS Medicine, Numéro 15491676, 2014, Page(s) e1001606, ISSN 1549-1676 Éditeur: PLOS DOI: 10.1371/journal.pmed.1001606 Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis Auteurs: Beben Benyamin, Tonu Esko, Janina S. Ried, Aparna Radhakrishnan, Sita H. Vermeulen, Michela Traglia, Martin Gögele, Denise Anderson, Linda Broer, Clara Podmore, Jiańan Luan, Zoltan Kutalik, Serena Sanna, Peter van der Meer, Toshiko Tanaka, Fudi Wang, Harm-Jan Westra, Lude Franke, Evelin Mihailov, Lili Milani, Jonas Hälldin, Juliane Winkelmann, Thomas Meitinger, Joachim Thiery, Annette Peters, Melanie Waldenberger, Augusto Rendon, Jennifer Jolley, Jennifer Sambrook, Lambertus A. Kiemeney, Fred C. Sweep, Cinzia F. Sala, Christine Schwienbacher, Irene Pichler, Jennie Hui, Ayse Demirkan, Aaron Isaacs, Najaf Amin, Maristella Steri, Gérard Waeber, Niek Verweij, Joseph E. Powell, Dale R. Nyholt, Andrew C. Heath, Pamela A. F. Madden, Peter M. Visscher, Margaret J. Wright, Grant W. Montgomery, Nicholas G. Martin, Dena Hernandez, Stefania Bandinelli, Pim van der Harst, Manuela Uda, Peter Vollenweider, Robert A. Scott, Claudia Langenberg, Nicholas J. Wareham, Cornelia van Duijn, John Beilby, Peter P. Pramstaller, Andrew A. Hicks, Willem H. Ouwehand, Konrad Oexle, Christian Gieger, Andres Metspalu, Clara Camaschella, Daniela Toniolo, Dorine W. Swinkels, John B Whitfield Publié dans: Nature Communications, Numéro 20411723, 2015, Page(s) 6542, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms7542 Sex- and age-interacting eQTLs in human complex diseases Auteurs: C. Yao, R. Joehanes, A. D. Johnson, T. Huan, T. Esko, S. Ying, J. E. Freedman, J. Murabito, K. L. Lunetta, A. Metspalu, P. J. Munson, D. Levy Publié dans: Human Molecular Genetics, Numéro 09646906, 2014, Page(s) 1947-1956, ISSN 0964-6906 Éditeur: Oxford University Press DOI: 10.1093/hmg/ddt582 Genetics of rheumatoid arthritis contributes to biology and drug discovery Auteurs: Yukinori Okada, Di Wu, Gosia Trynka, Towfique Raj, Chikashi Terao, Katsunori Ikari, Yuta Kochi, Koichiro Ohmura, Akari Suzuki, Shinji Yoshida, Robert R. Graham, Arun Manoharan, Ward Ortmann, Tushar Bhangale, Joshua C. Denny, Robert J. Carroll, Anne E. Eyler, Jeffrey D. Greenberg, Joel M. Kremer, Dimitrios A. Pappas, Lei Jiang, Jian Yin, Lingying Ye, Ding-Feng Su, Jian Yang, Gang Xie, Ed Keystone, Harm-Jan Westra, Tõnu Esko, Andres Metspalu, Xuezhong Zhou, Namrata Gupta, Daniel Mirel, Eli A. Stahl, Dorothée Diogo, Jing Cui, Katherine Liao, Michael H. Guo, Keiko Myouzen, Takahisa Kawaguchi, Marieke J. H. Coenen, Piet L. C. M. van Riel, Mart A. F. J. van de Laar, Henk-Jan Guchelaar, Tom W. J. Huizinga, Philippe Dieudé, Xavier Mariette, S. Louis Bridges Jr, Alexandra Zhernakova, Rene E. M. Toes, Paul P. Tak, Corinne Miceli-Richard, So-Young Bang, Hye-Soon Lee, Javier Martin, Miguel A. Gonzalez-Gay, Luis Rodriguez-Rodriguez, Solbritt Rantapää-Dahlqvist, Lisbeth Ärlestig, Hyon K. Choi, Yoichiro Kamatani, Pilar Galan, Mark Lathrop, Steve Eyre, John Bowes, Anne Barton, Niek de Vries, Larry W. Moreland, Lindsey A. Criswell, Elizabeth W. Karlson, Atsuo Taniguchi, Ryo Yamada, Michiaki Kubo, Jun S. Liu, Sang-Cheol Bae, Jane Worthington, Leonid Padyukov, Lars Klareskog, Peter K. Gregersen, Soumya Raychaudhuri, Barbara E. Stranger, Philip L. De Jager, Lude Franke, Peter M. Visscher, Matthew A. Brown, Hisashi Yamanaka, Tsuneyo Mimori, Atsushi Takahashi, Huji Xu, Timothy W. Behrens, Katherine A. Siminovitch, Shigeki Momohara, Fumihiko Matsuda, Kazuhiko Yamamoto, Robert M. Plenge Publié dans: Nature, Numéro 00280836, 2013, Page(s) 376-381, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature12873 Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance Auteurs: Y. F. M. Ramos, S. Metrustry, N. Arden, A. C. Bay-Jensen, M. Beekman, A. J. M. de Craen, L. A. Cupples, T. Esko, E. Evangelou, D. T. Felson, D. J. Hart, J. P. A. Ioannidis, M. Karsdal, M. Kloppenburg, F. Lafeber, A. Metspalu, K. Panoutsopoulou, P. E. Slagboom, T. D. Spector, E. W. E. van Spil, A. G. Uitterlinden, Y. Zhu, A. M. Valdes, J. B. J. van Meurs, I. Meulenbelt, P. Arp, M. Jhamai, M. Moorhouse, M. Verkerk, S. Bervoets, T. A Knoch, L. V. de Zeeuw, A. Abuseiris, R. de Graaf, A. Chaney, R. Ravindrarajah, D. Simpkin, C. Hinds, T. Dibling, P. Martin, S. Potter, A. Palotie, N. Soranzo Publié dans: Journal of Medical Genetics, Numéro 00222593, 2014, Page(s) 596-604, ISSN 0022-2593 Éditeur: British Medical Association DOI: 10.1136/jmedgenet-2014-102478 Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index Auteurs: Jian Yang, Andrew Bakshi, Zhihong Zhu, Gibran Hemani, Anna A E Vinkhuyzen, Sang Hong Lee, Matthew R Robinson, John R B Perry, Ilja M Nolte, Jana V van Vliet-Ostaptchouk, Harold Snieder, Tonu Esko, Lili Milani, Reedik Mägi, Andres Metspalu, Anders Hamsten, Patrik K E Magnusson, Nancy L Pedersen, Erik Ingelsson, Nicole Soranzo, Matthew C Keller, Naomi R Wray, Michael E Goddard, Peter M Visscher Publié dans: Nature Genetics, Numéro 10614036, 2015, Page(s) 1114-1120, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3390 Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci Auteurs: Lam C. Tsoi, Sarah L. Spain, Eva Ellinghaus, Philip E. Stuart, Francesca Capon, Jo Knight, Trilokraj Tejasvi, Hyun M. Kang, Michael H. Allen, Sylviane Lambert, Stefan W. Stoll, Stephan Weidinger, Johann E. Gudjonsson, Sulev Koks, Külli Kingo, Tonu Esko, Sayantan Das, Andres Metspalu, Michael Weichenthal, Charlotta Enerback, Gerald G. Krueger, John J. Voorhees, Vinod Chandran, Cheryl F. Rosen, Proton Rahman, Dafna D. Gladman, Andre Reis, Rajan P. Nair, Andre Franke, Jonathan N.W.N. Barker, Goncalo R. Abecasis, Richard C. Trembath, James T. Elder Publié dans: Nature Communications, Numéro 20411723, 2015, Page(s) 7001, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/ncomms8001 Somatic mosaicism for copy-neutral loss of heterozygosity and DNA copy number variations in the human genome Auteurs: Olga Žilina, Marina Koltšina, Raivo Raid, Ants Kurg, Neeme Tõnisson, Andres Salumets Publié dans: BMC Genomics, Numéro 14712164, 2015, ISSN 1471-2164 Éditeur: BioMed Central DOI: 10.1186/s12864-015-1916-3 Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity Auteurs: Christina L Usher, Robert E Handsaker, Tõnu Esko, Marcus A Tuke, Michael N Weedon, Alex R Hastie, Han Cao, Jennifer E Moon, Seva Kashin, Christian Fuchsberger, Andres Metspalu, Carlos N Pato, Michele T Pato, Mark I McCarthy, Michael Boehnke, David M Altshuler, Timothy M Frayling, Joel N Hirschhorn, Steven A McCarroll Publié dans: Nature Genetics, Numéro 10614036, 2015, Page(s) 921-925, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/ng.3340 Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits Auteurs: Zhihong Zhu, Andrew Bakshi, Anna A.E. Vinkhuyzen, Gibran Hemani, Sang Hong Lee, Ilja M. Nolte, Jana V. van Vliet-Ostaptchouk, Harold Snieder, Tonu Esko, Lili Milani, Reedik Mägi, Andres Metspalu, William G. Hill, Bruce S. Weir, Michael E. Goddard, Peter M. Visscher, Jian Yang Publié dans: The American Journal of Human Genetics, Numéro 00029297, 2015, Page(s) 377-385, ISSN 0002-9297 Éditeur: University of Chicago Press DOI: 10.1016/j.ajhg.2015.01.001 Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes Auteurs: Liina Tserel, Raivo Kolde, Maia Limbach, Konstantin Tretyakov, Silva Kasela, Kai Kisand, Mario Saare, Jaak Vilo, Andres Metspalu, Lili Milani, Pärt Peterson Publié dans: Scientific Reports, Numéro 20452322, 2015, Page(s) 13107, ISSN 2045-2322 Éditeur: Nature Publishing Group DOI: 10.1038/srep13107 New genetic loci link adipose and insulin biology to body fat distribution Auteurs: Dmitry Shungin, Thomas W. Winkler, Damien C. Croteau-Chonka, Teresa Ferreira, Adam E. Locke, Reedik Mägi, Rona J. Strawbridge, Tune H. Pers, Krista Fischer, Anne E. Justice, Tsegaselassie Workalemahu, Joseph M. W. Wu, Martin L. Buchkovich, Nancy L. Heard-Costa, Tamara S. Roman, Alexander W. Drong, Ci Song, Stefan Gustafsson, Felix R. Day, Tonu Esko, Tove Fall, Zoltán Kutalik, Jian’an Luan, Joshua C. Randall, André Scherag, Sailaja Vedantam, Andrew R. Wood, Jin Chen, Rudolf Fehrmann, Juha Karjalainen, Bratati Kahali, Ching-Ti Liu, Ellen M. Schmidt, Devin Absher, Najaf Amin, Denise Anderson, Marian Beekman, Jennifer L. Bragg-Gresham, Steven Buyske, Ayse Demirkan, Georg B. Ehret, Mary F. Feitosa, Anuj Goel, Anne U. Jackson, Toby Johnson, Marcus E. Kleber, Kati Kristiansson, Massimo Mangino, Irene Mateo Leach, Carolina Medina-Gomez, Cameron D. Palmer, Dorota Pasko, Sonali Pechlivanis, Marjolein J. Peters, Inga Prokopenko, Alena Stančáková, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Jana V. Van Vliet-Ostaptchouk, Loïc Yengo, Weihua Zhang, Eva Albrecht, Johan Ärnlöv, Gillian M. Arscott, Stefania Bandinelli, Amy Barrett, Claire Bellis, Amanda J. Bennett, Christian Berne, Matthias Blüher, Stefan Böhringer, Fabrice Bonnet, Yvonne Böttcher, Marcel Bruinenberg, Delia B. Carba, Ida H. Caspersen, Robert Clarke, E. Warwick Daw, Joris Deelen, Ewa Deelman, Graciela Delgado, Alex S. F. Doney, Niina Eklund, Michael R. Erdos, Karol Estrada, Elodie Eury, Nele Friedrich, Melissa E. Garcia, Vilmantas Giedraitis, Bruna Gigante, Alan S. Go, Alain Golay, Harald Grallert, Tanja B. Grammer, Jürgen Gräßler, Jagvir Grewal, Christopher J. Groves, Toomas Haller, Goran Hallmans, Catharina A. Hartman, Maija Hassinen, Caroline Hayward, Kauko Heikkilä, Karl-Heinz Herzig, Quinta Helmer, Hans L. Hillege, Oddgeir Holmen, Steven C. Hunt, Aaron Isaacs, Till Ittermann, Alan L. James, Ingegerd Johansson, Thorhildur Juliusdottir, Ioanna-Panagiota Kalafati, Leena Kinnunen, Wolfgang Koenig, Ishminder K. Kooner, Wolfgang Kratzer, Claudia Lamina, Karin Leander, Nanette R. Lee, Peter Lichtner, Lars Lind, Jaana Lindström, Stéphane Lobbens, Mattias Lorentzon, François Mach, Patrik K. E. Magnusson, Anubha Mahajan, Wendy L. McArdle, Cristina Menni, Sigrun Merger, Evelin Mihailov, Lili Milani, Rebecca Mills, Alireza Moayyeri, Keri L. Monda, Simon P. Mooijaart, Thomas W. Mühleisen, Antonella Mulas, Gabriele Müller, Martina Müller-Nurasyid, Ramaiah Nagaraja, Michael A. Nalls, Narisu Narisu, Nicola Glorioso, Ilja M. Nolte, Matthias Olden, Nigel W. Rayner, Frida Renstrom, Janina S. Ried, Neil R. Robertson, Lynda M. Rose, Serena Sanna, Hubert Scharnagl, Salome Scholtens, Bengt Sennblad, Thomas Seufferlein, Colleen M. Sitlani, Albert Vernon Smith, Kathleen Stirrups, Heather M. Stringham, Johan Sundström, Morris A. Swertz, Amy J. Swift, Ann-Christine Syvänen, Bamidele O. Tayo, Barbara Thorand, Gudmar Thorleifsson, Andreas Tomaschitz, Chiara Troffa, Floor V. A. van Oort, Niek Verweij, Judith M. Vonk, Lindsay L. Waite, Roman Wennauer, Tom Wilsgaard, Mary K. Wojczynski, Andrew Wong, Qunyuan Zhang, Jing Hua Zhao, Eoin P. Brennan, Murim Choi, Per Eriksson, Lasse Folkersen, Anders Franco-Cereceda, Ali G. Gharavi, Åsa K. Hedman, Marie-France Hivert, Jinyan Huang, Stavroula Kanoni, Fredrik Karpe, Sarah Keildson, Krzysztof Kiryluk, Liming Liang, Richard P. Lifton, Baoshan Ma, Amy J. McKnight, Ruth McPherson, Andres Metspalu, Josine L. Min, Miriam F. Moffatt, Grant W. Montgomery, Joanne M. Murabito, George Nicholson, Dale R. Nyholt, Christian Olsson, John R. B. Perry, Eva Reinmaa, Rany M. Salem, Niina Sandholm, Eric E. Schadt, Robert A. Scott, Lisette Stolk, Edgar E. Vallejo, Harm-Jan Westra, Krina T. Zondervan, Philippe Amouyel, Dominique Arveiler, Stephan J. L. Bakker, John Beilby, Richard N. Bergman, John Blangero, Morris J. Brown, Michel Burnier, Harry Campbell, Aravinda Chakravarti, Peter S. Chines, Simone Claudi-Boehm, Francis S. Collins, Dana C. Crawford, Jo Publié dans: Nature, Numéro 00280836, 2015, Page(s) 187-196, ISSN 0028-0836 Éditeur: Nature Publishing Group DOI: 10.1038/nature14132 Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank Auteurs: Louise V Wain, Nick Shrine, Suzanne Miller, Victoria E Jackson, Ioanna Ntalla, María Soler Artigas, Charlotte K Billington, Abdul Kader Kheirallah, Richard Allen, James P Cook, Kelly Probert, Ma'en Obeidat, Yohan Bossé, Ke Hao, Dirkje S Postma, Peter D Paré, Adaikalavan Ramasamy, Reedik Mägi, Evelin Mihailov, Eva Reinmaa, Erik Melén, Jared O'Connell, Eleni Frangou, Olivier Delaneau, Colin Freeman, Desislava Petkova, Mark McCarthy, Ian Sayers, Panos Deloukas, Richard Hubbard, Ian Pavord, Anna L Hansell, Neil C Thomson, Eleftheria Zeggini, Andrew P Morris, Jonathan Marchini, David P Strachan, Martin D Tobin, Ian P Hall Publié dans: The Lancet Respiratory Medicine, Numéro 22132600, 2015, Page(s) 769-781, ISSN 2213-2600 Éditeur: Elsevier Limited DOI: 10.1016/S2213-2600(15)00283-0 Cell Specific eQTL Analysis without Sorting Cells Auteurs: Harm-Jan Westra, Danny Arends, Tõnu Esko, Marjolein J. Peters, Claudia Schurmann, Katharina Schramm, Johannes Kettunen, Hanieh Yaghootkar, Benjamin P. Fairfax, Anand Kumar Andiappan, Yang Li, Jingyuan Fu, Juha Karjalainen, Mathieu Platteel, Marijn Visschedijk, Rinse K. Weersma, Silva Kasela, Lili Milani, Liina Tserel, Pärt Peterson, Eva Reinmaa, Albert Hofman, André G. Uitterlinden, Fernando Rivadeneira, Georg Homuth, Astrid Petersmann, Roberto Lorbeer, Holger Prokisch, Thomas Meitinger, Christian Herder, Michael Roden, Harald Grallert, Samuli Ripatti, Markus Perola, Andrew R. Wood, David Melzer, Luigi Ferrucci, Andrew B. Singleton, Dena G. Hernandez, Julian C. Knight, Rossella Melchiotti, Bernett Lee, Michael Poidinger, Francesca Zolezzi, Anis Larbi, De Yun Wang, Leonard H. van den Berg, Jan H. Veldink, Olaf Rotzschke, Seiko Makino, Veikko Salomaa, Konstantin Strauch, Uwe Völker, Joyce B. J. van Meurs, Andres Metspalu, Cisca Wijmenga, Ritsert C. Jansen, Lude Franke Publié dans: PLOS Genetics, Numéro 15537404, 2015, Page(s) e1005223, ISSN 1553-7404 Éditeur: Public Library of Science DOI: 10.1371/journal.pgen.1005223 Effects of Metformin on Metabolite Profiles and LDL Cholesterol in Patients With Type 2 Diabetes Auteurs: Tao Xu, Stefan Brandmaier, Ana C. Messias, Christian Herder, Harmen H.M. Draisma, Ayse Demirkan, Zhonghao Yu, Janina S. Ried, Toomas Haller, Margit Heier, Monica Campillos, Gisela Fobo, Renee Stark, Christina Holzapfel, Jonathan Adam, Shen Chi, Markus Rotter, Tommaso Panni, Anne S. Quante, Ying He, Cornelia Prehn, Werner Roemisch-Margl, Gabi Kastenmüller, Gonneke Willemsen, René Pool, Katarina Kasa, Ko Willems van Dijk, Thomas Hankemeier, Christa Meisinger, Barbara Thorand, Andreas Ruepp, Martin Hrabé de Angelis, Yixue Li, H.-Erich Wichmann, Bernd Stratmann, Konstantin Strauch, Andres Metspalu, Christian Gieger, Karsten Suhre, Jerzy Adamski, Thomas Illig, Wolfgang Rathmann, Michael Roden, Annette Peters, Cornelia M. van Duijn, Dorret I. Boomsma, Thomas Meitinger, Rui Wang-Sattler Publié dans: Diabetes Care, Numéro 01495992, 2015, Page(s) 1858-1867, ISSN 0149-5992 Éditeur: American Diabetes Association DOI: 10.2337/dc15-0658 Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults Auteurs: E. Zimmermann, L. H. Ängquist, S. S. Mirza, J. H. Zhao, D. I. Chasman, K. Fischer, Q. Qi, A. V. Smith, M. Thinggaard, M. N. Jarczok, M. A. Nalls, S. Trompet, N. J. Timpson, B. Schmidt, A. U. Jackson, L. P. Lyytikäinen, N. Verweij, M. Mueller-Nurasyid, M. Vikström, P. Marques-Vidal, A. Wong, K. Meidtner, R. P. Middelberg, R. J. Strawbridge, L. Christiansen, K. O. Kyvik, A. Hamsten, T. Jääskeläinen, A. Tjønneland, J. G. Eriksson, J. B. Whitfield, H. Boeing, R. Hardy, P. Vollenweider, K. Leander, A. Peters, P. van der Harst, M. Kumari, T. Lehtimäki, A. Meirhaeghe, J. Tuomilehto, K.-H. Jöckel, Y. Ben-Shlomo, N. Sattar, S. E. Baumeister, G. Davey Smith, J. P. Casas, D. K. Houston, W. März, K. Christensen, V. Gudnason, F. B. Hu, A. Metspalu, P. M. Ridker, N. J. Wareham, R. J. F. Loos, H. Tiemeier, E. Sonestedt, T. I. A. Sørensen Publié dans: Obesity Reviews, Numéro 14677881, 2015, Page(s) 327-340, ISSN 1467-7881 Éditeur: Blackwell Publishing Inc. DOI: 10.1111/obr.12263 Non-peer reviewed articles (1) ePerMed - Rise of scientific excellence and collaboration for implementing personalised medicine in Estonia - H2020 Auteurs: Andres Metspalu Publié dans: Impact, Numéro 2018/7, 2018, Page(s) 53-55, ISSN 2398-7073 Éditeur: Science Impact Ltd DOI: 10.21820/23987073.2018.7.53 Book chapters (1) Comprehensive Meta-analysis of MicroRNA Expression Using a Robust Rank Aggregation Approach Auteurs: Urmo Võsa, Raivo Kolde, Jaak Vilo, Andres Metspalu, Tarmo Annilo Publié dans: RNA Mapping, 2014, Page(s) 361-373, ISBN 978-1-4939-1062-5 Éditeur: Springer New York DOI: 10.1007/978-1-4939-1062-5_28 Recherche de données OpenAIRE... Une erreur s’est produite lors de la recherche de données OpenAIRE Aucun résultat disponible
