DE69319336T2 - N-acylierte 2'-deoxycytidine für die oligonukleotid synthese - Google Patents

N-acylierte 2'-deoxycytidine für die oligonukleotid synthese

Info

Publication number
DE69319336T2
DE69319336T2 DE69319336T DE69319336T DE69319336T2 DE 69319336 T2 DE69319336 T2 DE 69319336T2 DE 69319336 T DE69319336 T DE 69319336T DE 69319336 T DE69319336 T DE 69319336T DE 69319336 T2 DE69319336 T2 DE 69319336T2
Authority
DE
Germany
Prior art keywords
deoxycytidine
acylated
oligonucleotid
synthesis
oligonucleotid synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69319336T
Other languages
English (en)
Other versions
DE69319336D1 (de
Inventor
Parameswara Reddy
Naeem Hanna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Coulter Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Coulter Inc filed Critical Beckman Coulter Inc
Application granted granted Critical
Publication of DE69319336D1 publication Critical patent/DE69319336D1/de
Publication of DE69319336T2 publication Critical patent/DE69319336T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69319336T 1992-04-24 1993-04-09 N-acylierte 2'-deoxycytidine für die oligonukleotid synthese Expired - Lifetime DE69319336T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/873,330 US5428148A (en) 1992-04-24 1992-04-24 N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
PCT/US1993/003337 WO1993022326A1 (en) 1992-04-24 1993-04-09 Protecting groups useful in oligonucleotide synthesis

Publications (2)

Publication Number Publication Date
DE69319336D1 DE69319336D1 (de) 1998-07-30
DE69319336T2 true DE69319336T2 (de) 1998-11-26

Family

ID=25361423

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69319336T Expired - Lifetime DE69319336T2 (de) 1992-04-24 1993-04-09 N-acylierte 2'-deoxycytidine für die oligonukleotid synthese

Country Status (5)

Country Link
US (1) US5428148A (de)
EP (1) EP0637314B1 (de)
JP (1) JP3368352B2 (de)
DE (1) DE69319336T2 (de)
WO (1) WO1993022326A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10247790A1 (de) * 2002-10-14 2004-04-22 Chemogenix Gmbh Verfahren zur Herstellung von Oligonukleotidkonjugaten
DE10324063A1 (de) * 2003-05-27 2004-12-23 Robert Heinrich Verfahren zur Herstellung von auf porösem Glas gebundenen Nucleotiden

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* Cited by examiner, † Cited by third party
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US5428148A (en) 1995-06-27
DE69319336D1 (de) 1998-07-30
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