Cephalotaxus alkaloids
Cephalotaxus alkaloids are natural products characterized by pentacyclic structure.
Occurrence[edit]
These alkaloids are commonly found in the plum yew species (Cephalotaxus), especially in the Japanese plum-yew.[1]
Representative[edit]
The most important representative is cephalotaxin. Other notable representatives include harringtonine and homoharringtonine.[1]
-
(-)-Cephalotaxin -
(-)-Harringtonine -
(-)-Homoharringtonine
-Cephalotaxine_Structural_Formula_V1.svg)
-Harringtonine_Structural_Formula_V1.svg)
-Homoharringtonine_Structural_Formula_V1.svg)
Properties[edit]
Harringtonine and homoharringtonine exhibit antitumor activity and act against murine leukemia cells. They serve as protein and DNA biosynthesis inhibitors and are used against acute myelocytoxic leukemia.[1]
References[edit]
- ^ a b c Entry on Cephalotaxus-Alkaloide. at: Römpp Online. Georg Thieme Verlag, retrieved {{{Datum}}}.